Effect of DNA Variations on Breast Cancer Risk and Recurrence. A Study of The Cancer Institute of New Jersey Oncology Group (CINJOG)

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Effect of DNA Variations on Breast Cancer Risk and Recurrence. A Study of The Cancer Institute of New Jersey Oncology Group (CINJOG)

The purpose of this study is to collect, store and analyze deoxyribonucleic acid (DNA) from patients. Your genes are inherited from your parents and they are in part responsible for why you are different from other people. These slight differences in genes among people are called polymorphisms. By collecting DNA from patients with cancer and without, scientists will be able to study whether these polymorphisms are important in determining the occurrence of cancer and how patients respond to cancer treatments. For example, having a particular polymorphism in a gene may affect the type of side effects you may have from certain drugs during treatment compared to a person who does not have this polymorphism.
Recently several SNPs in particular genes have been identified that may play a role in the earlier development of breast cancer. We want to determine if these SNPs are seen more often in patients with breast cancer as compared with patients of the same age without a diagnosis of breast cancer. We also want to determine if these SNPs are seen more often in patients experiencing a breast cancer recurrence than those remaining cancer-free.

Previous biopsy-confirmed diagnosis of breast cancer including DCIS and invasive ductal carcinoma

Protocol Number040406
Principal InvestigatorKim Hirshfield
ScopeLocal
Applicable Disease SitesBreast - Female
Participating InstitutionsSouthern Ocean Medical Center
Rutgers Cancer Institute of New Jersey
Morristown Medical Center
Jersey Shore University Medical Center
Bayshore Community Hospital
Riverview Medical Center
University Medical Center at Princeton

For further information on this clinical trial, please contact us at 732-235-8675 or cinjclinicaltrials@umdnj.edu.