Cell Death and Survival Signaling Program

Program Leader: Eileen White, PhD


Overall Goals:

To lead to a better understanding of basic mechanisms of tumor cell survival and cancer cell metabolism, and to identify new targets for drug development to improve cancer therapy.

Specific Aims:

  • To define the basic mechanisms of apoptosis inactivation in tumor cells and to develop anti-cancer therapies to restore apoptotic function to achieve tumor regression.
  • To establish the role of the metabolic stress resistance mechanism of autophagy in cancer, to determine the role of autophagy in controlling cancer cell metabolism, and to modulate metabolic pathways to improve cancer therapy.
  • To identify signal transduction pathways that regulate tumor cell survival and to modulate signaling to achieve therapeutic tumor cell death.

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