Cell Death and Survival Signaling Program
Overall Goals:
To determine the mechanisms regulating tumor cell death and survival and to apply this knowledge to treating human malignancies.
Specific Aims:
- To define the basic mechanisms of apoptosis inactivation in tumor cells and to develop anti-cancer therapies to restore apoptotic function to achieve tumor regression.
- To establish the role of metabolism and the metabolic stress resistance mechanism of autophagy in cancer and to modulate the autophagy pathway for cancer prevention and therapy.
- To identify signal transduction pathways that regulate tumor cell survival and to modulate signaling to achieve therapeutic tumor cell death.
CALENDAR: Research Program Meetings, Distinguished Lecture Series, and other events for CINJ Members
Keystone Symposia: Metabolism and Cancer Progression, March 12-17, 2010
Keystone Symposia: Cell Death Pathways: Apoptosis, Autophagy and Necrosis, March 12-17, 2010
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