Wright Chemistry Building
610 Taylor Road, Room A108
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How chemicals interact with biological systems
Cancer and aging
The role of polyamines, hypusine and eIF-5A in cancer
The role of transcription factors such as NF-Y in cell aging
Screening for natural products that may have cancer preventive effect.
Tao, Y. and Chen, K.Y. Purification of deoxyhypusine synthase from Neurospora crassa to homogeneity by substrate elution affinity chromatography. J. Biol. Chem., 270, 383-386, 1995.
Tao, Y. and Chen, K.Y. Molecular cloning and functional expression of Neurospora deoxyhypusine synthase cDNA and identification of yeast ,deoxyhypusine synthase cDNA. J. Biol. Chem., 270, 23984-23987, 1995.
Chen, Z.P., Yan, Y.P., Ding, Q., Potenza, J.A., Knapp, S., Schugar, H.J. Chen, K.Y. Effects ofinhibitors of deoxyhypusine synthase on the differentiation of mouse neuroblastoma and erythroleukemia cells. Cancer Letters, 105, 233-239, 1996.
Caruccio, L., Bae, S., Liu, A.Y-C. and Chen, K.Y. Rapid activation of the heat shock factor, HSF1, by hyper- and hypo-osmotic stress in mammalian cells. Biochemical J., 327, 341-347, 1997.
Chen, Z..P. and Chen K.Y. Marked elevation of hypusine formation activity on eukaryotic initiation factor 5A in v-HA-RAS transformed mouse NIH3T3 cells. Cancer Lett. 115, 235-241, 1997.
Chen, K.Y. and Liu, A.Y.-C. Hypusine formation on eukaryotic initiation factor 5A, biochemistry andfunction. Biol. Signals, 6, 105-109, 1997.
Chen, K.Y. Study of polyphosphate metabolism by 31P nuclear magnetic resonance spectroscopy. in “Progesss in Molecular and Subcellular Biology” (ed. Schroder, H.C.), Springer Verlag, Germany, pp. 253-273, 1999
Lu, J.B., Park, J., Liu, A.Y-C. and Chen, K.Y. Osmotic stress-induced activation of HSF1 DNA binding activity is dramatically attenuated in senescent human cells. J. Cell. Physiol., 184, 183-190, 2000.
Matuoka, K. and Chen, K.Y. Possible role of subunit A of nuclear factor Y (NF-Y) in normal human diploid fibroblasts during senescence. Biogerontology, 1, 261-271, 2000.
Lu, J.B., Ho, C.-T. , Ghai, G. and Chen, K.Y. Differential effects of theaflavin monogallates on cell growth, apoptosis and Cox-2 gene expression in cancerous versus normal cells. Cancer Research, 60, 6465-6471, 2000.
Lu, J., Chen, Z.P., Yan, Y.P., Knapp, S., Schugar, H. and Chen, K.Y. 6-Aminohexanoic hydroxamate is a potent inducer of the differentiation of mouse neuroblastoma cells. Cancer Lett., 160, 59-66,2000.
Xu, A. and Chen, K.Y. Hypusine is required for a sequence-specific interaction of eukaryotic initiation factor 5A with post-SELEX RNA. J. Biol Chem., 276, 2555-2561, 2001.
Lu, J.B., Ho, C.-T. , Ghai, G. and Chen, K.Y. Resveratrol analog, 3, 4, 4', 5-tetrahydroxystilbene, differentially induces pro-apoptotic p53/Bax gene expression and inhibits the growth of transformed cells but not their normal counterparts. Carcinogenesis, 22, 321-328, 2001.
Matuoka, K., Chen, K.Y. and Takenawa, T. Rapid reversion of aging phenotypes by nicotinamide through possible modulation of histone acetylation. Cell. Mol. Life Sciences, 58, 2108-2116, 2001.
Jao, D.L. and Chen, K.Y. Subcellular localization of the hypusine-containing eukaryotic initiation factor 5A by immunofluorescent staining and Green Fluorescent protein tagging. J. Cell. Biochem., 86, 590-600, 2002.