Researcher Profiles

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Nancy C. Walworth, PhD

Selected Publications

  1. Lundgren, K., N. Walworth, R. Booher, M. Dembski, M. Kirschner and D. Beach. 1991. Mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2. Cell. 64:1111-1120. PMID: 1706223
  2. Walworth, N., S. Davey and D. Beach. 1993. Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2. Nature 363:368-371. PMID: 8497322
  3. Walworth, N. C. and R. Bernards. 1996. rad-Dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint. Science 271:353-356. PMID: 8553071
  4. Chen, L., T-H. Liu and N. C. Walworth. 1999. Association of Chk1 with 14-3-3 proteins is stimulated by DNA damage. Genes and Development 13:675-685. PMID: 10090724
  5. Wan, S., H. Capasso and N. C. Walworth. 1999. The topoisomerase I poison camptothecin generates a Chk1-dependent DNA damage checkpoint signal in fission yeast. Yeast 15:821-828. PMID: 10407262
  6. Wan, S. and N. C. Walworth. 2001. A novel genetic screen yields checkpoint defective alleles of Schizosaccharomyces pombe chk1. Current Genetics 38:299-306. PMID: 11270571
  7. Capasso, H., C. Palermo, S. Wan, H. Rao, U. P. John, M. J. O’Connell, and N. C. Walworth. 2002. Phosphorylation activates Chk1 and is required for checkpoint-mediated cell cycle arrest. J. Cell Science, 115:4555-4564. PMID: 12415000
  8. Colon-Berlingeri, M. and N. C. Walworth. 2003. Use of in vivo Gap Repair for Isolation of Mutant Alleles of a Checkpoint Gene, in Methods in Molecular Biology, vol. 241: Cell Cycle Checkpoint Controls Protocols. pages 175-187. H. B. Lieberman, Ed. Humana Press Inc., Totowa, NJ. PMID: 14970653
  9. Ahmed, S., C. Palermo, H. Rao, and N. C. Walworth. 2004. A novel protein with similarities to Rb binding protein 2 compensates for lack of Chk1 function and affects histone modification in fission yeast. Molecular and Cellular Biology 24(9):3660-3669. PMID: 15082762
  10. Dunaway, S., H.-Y. Liu, and N. C. Walworth. 2005. Interaction of 14-3-3 protein with Chk1 affects localization and checkpoint function. J. Cell Science 118:39-50. PMID: 15585577
  11. Dul, B.E. and N. C. Walworth. 2007. The PHD fingers of fission yeast Msc1 exhibit E3 ubiquitin ligase activity. J. Biological Chemistry, 282:18397-18406. PMID: 17456468
  12. Ahmed, S., B.E. Dul, Qiu, X. and N. C. Walworth. 2007. Msc1 acts through histone H2A.Z to promote chromosome stability in fission yeast. Genetics, 177:1487-1497. PMID: 17947424
  13. Palermo, C., Hope, J. C., Freyer, G. A., Rao, H. and N. C. Walworth. 2008. Importance of a C-terminal conserved region of Chk1 for checkpoint function. PLoS ONE 3(1):e1427. PMID: 18183307
  14. Qiu, X., B.E. Dul and N. C. Walworth. 2010. Activity of a C-terminal Plant Homeodomain (PHD) of Msc1 is essential for function. J. Biological Chemistry, 285:36828-35. PMID: 20858896
  15. Belfield, C., C. Queenan, H. Rao, K. Kitamura and N. C. Walworth. 2014. The oxidative stress responsive transcription factor Pap1 confers DNA damage resistance on checkpoint-deficient fission yeast cells. PLoS One. 9(2):e89936. PMID:24587136.