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Mengqing Xiang, PhD

Selected Publications

  1. Xiang, M., Zhou, L., Peng, Y.-W., Eddy, R. L., Shows, T. B., and Nathans, J. (1993) Brn-3b: a POU-domain gene expressed in a subset of retinal ganglion cells. Neuron 11:689-701. (PMID: 7691107)
  2. Gan, L., Xiang, M.*, Zhou, L., Wagner, D., Klein, W. H., and Nathans, J. (1996) POU domain factor Brn-3b is required for the development of a large set of retinal ganglion cells. Proc. Natl. Acad. Sci. USA 93:3920-3925. (*Co-first author) (PMCID: PMC39460)
  3. Xiang, M., Gan, L., Zhou, L., Klein, W. H., and Nathans, J. (1996) Targeted deletion of the mouse POU domain gene Brn-3a causes a selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling. Proc. Natl. Acad. Sci. USA 93:11950-11955. (PMCID: PMC38164)
  4. Xiang, M., Gan, L., Li, D., Chen, Z.-Y., Zhou, L., O’Malley, B. W., Klein, W. H., and Nathans, J. (1997) Essential role of POU-domain factor Brn-3c in auditory and vestibular hair cell development. Proc. Natl. Acad. Sci. USA 94:9445-9450. (PMCID: PMC23217)
  5. Liu, W., Mo, Z., and Xiang, M. (2001) The Ath5 proneural genes function upstream of Brn3 POU domain transcription factor genes to promote retinal ganglion cell development. Proc. Natl. Acad. Sci. USA 98:1649-1654. (PMCID: PMC29311)
  6. Li, S., Price, S. M., Cahill, H., Ryugo, D. K., Shen, M. M., and Xiang, M. (2002) Hearing loss caused by progressive degeneration of cochlear hair cells in mice deficient for the Barhl1 homeobox gene. Development 129:3523-3532. (PMID: 12091321).
  7. Mo, Z., Li, S., Yang, X., and Xiang, M. (2004) Role of the Barhl2 homeobox gene in the specification of glycinergic amacrine cells. Development 131:1607-1618. (PMID: 14998930)
  8. Li, S., Mo, Z., Yang, X., Price, S. M., Shen, M. M., and Xiang, M. (2004) Foxn4 controls the genesis of amacrine and horizontal cells by retinal progenitors. Neuron 43:795-807. (PMID: 15363391)
  9. Li, S., Misra, K., Matise, M., and Xiang, M. (2005) Foxn4 acts synergistically with Mash1 to specify subtype identity of V2 interneurons in the spinal cord. Proc. Natl. Acad. Sci. USA 102:10688-10693. (PMCID: PMC1180804)
  10. Qiu, F., Jiang, H., and Xiang, M. (2008) A comprehensive negative regulatory program controlled by Brn3b to ensure ganglion cell specification from multipotential retinal precursors. J. Neurosci. 28:3392-3403. (PMCID: PMC2459333)
  11. Jiang, H. and Xiang, M. (2009) Subtype specification of GABAergic amacrine cells by the orphan nuclear receptor Nr4a2/Nurr1. J. Neurosci. 29:10449-10459. (PMCID: PMC2751734)
  12. Jin, K., Jiang, H., Mo, Z., and Xiang, M. (2010) Early B-cell factors are required for specifying multiple retinal cell types and subtypes from postmitotic precursors. J. Neurosci. 30:11902-11916. (PMCID: PMC2951389)
  13. Luo, H., Jin, K., Xie, Z., Qiu, F., Li, S., Zou, M., Cai, L., Hozumi, K., Shima, D. T., and Xiang, M. (2012) Forkhead box N4 (Foxn4) activates Dll4-Notch signaling to suppress photoreceptor cell fates of early retinal progenitors. Proc. Natl. Acad. Sci. USA 109:E553-E562. (PMCID: PMC3295323)
  14. Xiang, M. (2013) Intrinsic control of mammalian retinogenesis. Cell. Mol. Life Sci. 70:2519-2532. (PMCID: PMC3566347)
  15. Misra, K., Luo, H., Li, S., Matise, M., and Xiang, M. (2014) Asymmetric activation of Dll4-Notch signaling by Foxn4 and proneural factors activates BMP/TGFb signaling to specify V2b interneurons in the spinal cord. Development 141:187-198. (PMCID: PMC3865758)