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Helmut Zarbl, PhD

Selected Publications

  1. Ricicki, E. M., Luo, W., Fan, W., Zhao, L.P., Zarbl, H. and Vouros. P. (2006) Quantification of N-(deoxyguanosin-8-yl)-4-aminobiphenyl adducts in human lymphoblastoid TK6 cells dosed with N-hydroxy-4-acetylaminobiphenyl and their relationship to mutation, toxicity, and gene expression profiling. Analytical Chemistry 78(18):6422-32.
  2. Mikheev, A. M., Mikheeva, S. A., Rostomily, R., and Zarbl, H. (2007). Dickkopf-1 activates cell death in MDA-MB435 melanoma cells. Biochemical and Biophysical Research Communications 352, 675-680.
  3. Olsavsky, K. M., Page, J. L., Johnson, M. C., Zarbl, H., Strom, S. C., and Omiecinski, C. J. (2007). Gene expression profiling and differentiation assessment in primary human hepatocyte cultures, established hepatoma cell lines, and human liver tissues. Toxicology and Applied Pharmacology 222, 42-56.
  4. Page, J. L., Johnson, M. C., Olsavsky, K. M., Strom, S. C., Zarbl, H., and Omiecinski, C. J. (2007). Gene expression profiling of extracellular matrix as an effector of human hepatocyte phenotype in primary cell culture. Toxicol Sci 97, 384-397.
  5. Beyer,  R.P., Fry, R.C., Lasarev, M.R., McConnachie, L.A., Meira, L.B.,  Palmer, V., PowellC.L.,  Ross, P.K., Bammler, T.K.,  Bradford, B.U.,  Cranson, A.B.,  Cunningham, M.L.,  Fannin, R.D., Higgins, G.M.,  Hurban, P.,  Kayton, R.J.,  Kerr, K.F.,  Kosyk, O., Lobenhofer, E.K.,  Sieber, S.O.,  Vliet, P.A., Weis,  B.K., Wolfinger, R.,  Woods, C.G., Freedman, J.H.,  Linney, E.,  Kaufmann, W.K.,  Kavanagh, T.J.,  Paules, R.S.,  Rusyn, I.,  Samson, L.D.,  Spencer, P.,  Suk, W.,  Tennant, R.J.,  Zarbl, H.   (and other Members of the Toxicogenomics Research Consortium). (2007).  Multi-center study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses. Toxicological Sciences 99(1):326-337.
  6. Zarbl, H. Toxicogenomic Analyses of Genetic Susceptibility to Mammary Gland Carcinogenesis in Rodents: Implications for Human Breast Cancer. Breast Disease 28: 87-105, 2007.
  7. Ren, X., Zhang, X., Kim, A. S., Mikheev, A. M., Fang, M., Sullivan, R.Bumgarner, R., Zarbl, H.  Comparative Genomics of Susceptibility to Mammary Carcinogenesis among Inbred Rat Strains: Role of Reduced Prolactin Signaling in Resistance of the Copenhagen Strain. Carcinogenesis 29(1): 177-185 2007. ePub 2007/10/06
  8. Mikheev, A.M., Mikheeva, S.A., Rostomily, R., Swisshelm, K., and Zarbl, H.  (2008). Dickkopf-1 mediated tumor suppression in human breast carcinoma cell lines.  Breast Cancer Research and Treatment. 112(2):263-273. ePub 2007/12/25
  9. Zhang, X and Zarbl, H.  Chemopreventive Doses of Methylselenocysteine Alter Circadian Rhythm in Rat Mammary Tissue but Not Liver. (2008). Cancer Prevention Research 2(1):119-127.
  10. Sudo, H., Li-Sucholeiki, X.C., Marcelino, L.A., Gruhl, A.N., Herrero-Jimenez, P., Zarbl, H., Willey, J.C., Furth, E.E., Coller, H., Kurzweil, R., Ekstrom, P.O., Morgenthaler, S., Gostjeva, E.V., and Thilly, W.G. (2008) Fetal-juvenile origins of point mutations in the adult human tracheal-bronchial epithelium:  absence of detectable effects of age, gender or smoking status. Mutation Research 646:15-40, 2008.
  11. Zarbl. H., Gallo,M.A., Glick, J., Yeung, K.Y. and Vouros, P. (2010) The Vanishing Zero Revisited: Thresholds in the Age of Genomics. Chemico-Biological Interactions 184:273-278, 2010.
  12. Ming Zhu Fang, Xun Zhang and Helmut Zarbl. (2010). Methylselenocysteine Inhibits Carcinogenesis by Enhancing Circadian Expression of Melatonin Receptor 1α and Estrogen Receptor β in Rat Mammary Epithelial Cells.
  13. Cancer Prevention Research 3(5): 640-652, 2010. PubMed # 20424134 NIHMSID # 181679,  Publ.ID: CAPR-09-0170.
  14. Glen E Kisby, Rebecca C Fry, Michael Lasarev, Theodor K Bammler, Richard P Beyer, Monica Cherchwell, Daniel Doerge, Lisiane B Meira, Valerie S Palmer, Ana Luiza Ramos-Crawford, XueFeng Ren, Robert C Sullivan, Terrance Kavanagh, Leona D Samson, Helmut Zarbl, Peter Spencer. (2010) The Cycad Genotoxin MAM Modulates Cellular Pathways Involved in Cancer and Neurodegenerative Disease in a DNA Damage-Linked Manner. PLoS ONE 6(6): e20911. doi:10.1371/journal.pone.0020911
  15. Elisa V. Bandera, Urmila Chandran, Brian Buckley, Bozena Winnik, Yong Lin, Sastry Isukapalli, Ian Marshall, Melony King, and Helmut Zarbl. (2011). Urinary mycoestrogens, body size and breast development in New Jersey girls. Science of the Total Environment 409:5221-5227. PMID 21975003
  16. Jessica C. Graham and Helmut Zarbl. (2012). Use of Cell-SELEX to Generate DNA Aptamers as Molecular Probes of HPV-associated Cervical Cancer Cells PLoS ONE 7(4):1-9. e36103. PMC3335032
  17. Xuefeng Ren, Jessica C. Graham, Lichen Jing, Andrei M. Mikheev, Yuan Gao, Jie Lew, Hong Xie, Andrea S. Kim, Xiuling Shang, Cynthia Friedman, Graham Vail, Ming Zhu Fang, Yana Bromberg, and Helmut Zarbl. (2013). Mapping of Mcs30, a new mammary carcinoma susceptibility quantitative trait locus (QTL30) on rat chromosome 12: Identification of Fry as a candidate Mcs gene. PLoS One 8(9): e70930. doi:10.1371/journal.pone.0070930.
  18. Dwaipayan Mukherjee, Steven G. Royce, Jocelyn A. Alexander, Brian Buckley, Sastry S. Isukapalli, Elisa V. Bandera, Helmut Zarbl, and Panos G. Georgopoulos. (2014). Physiologically-Based Toxicokinetic Modeling of Zearalenone and its Metabolites: Application to the Jersey Girl Study. PLOS ONE 10.1371/journal.pone.0113632
  19. Lewis, CA, Gallo, MA, Reuhl, K, Zarbl, H.  In utero Exposure of Fisher 344 Rats to Low Doses of Zeranol via the Maternal Diet Produces Dose-Dependent Effects on Sexual Development and Reproduction. (2015) International Proceedings of Nutrition and Food Sciences 86:62-68 DOI: 10.7763/IPCBEE. 2015. V86. 10.
  20. Ashley L. Green, Saw C. Tee, Helmut Zarbl, Grace L. Guo, and Jason R. Richardson. (2015). Epigenetic Regulation of Dopamine Transporter Expression. Neurochem Res. Vol. 86 (2015) DOI: 10.7763/IPCBEE. 2015. V86. 10
  21. Ming Zhu Fang, Pamela Ohman-Strickland, Kathy Kelley McNeil, Howard Kipen, Benjamin Crabtree,  Jenny Pan Lew, and Helmut Zarbl. (2015). Sleep Interruption Associated with House Staff Work Schedules Alters Circadian Gene Expression. Sleep Medicine. doi:10.1016/j.sleep.2015.06.011.
  22. Paul Vouros; Joshua  J Klaene, Ph.D.; Caroline C Flarakos, Ph.D.; James Glick, Ph.D.; Jennifer T Barret, Ph.D.; Helmut Zarbl (2015) Tracking Matrix Effects in the Analysis of DNA Adducts of Polyaromatic Hydrocarbons. Journal of Chromatography A.  Accepted for publication.
  23. Mingzhu Fang, Wei-Ren Guo, Hwan-Goo Kang, and Helmut Zarbl (2015). Enhancement of NAD+-dependent SIRT1 Deacetylase Activity by Methylselenocysteine Resets Circadian Clock in Carcinogen-Treated Mammary Epithelial Cells. Oncotarget, In Press.