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Debra L. Laskin, PhD

Publications since 2011

Zheng, R. Dragomir, A. C. Mishin, V. Richardson, J. R. Heck, D. E. Laskin, D. L. Laskin, J. D. Differential metabolism of 4-hydroxynonenal in liver, lung and brain of mice and rats. Toxicol Appl Pharmacol, 279:43-52, . (PMID: 24832492)

Chang, Y. C. Wang, J. D. Hahn, R. A. Gordon, M. K. Joseph, L. B. Heck, D. E. Heindel, N. D. Young, S. C. Sinko, P. J. Casillas, R. P. Laskin, J. D. Laskin, D. L. Gerecke, D. R. Therapeutic Potential of a Non-Steroidal Bifunctional Anti-Inflammatory and Anti-Cholinergic Agent against Skin Injury Induced by Sulfur Mustard. Toxicol Appl Pharmacol, In process, . (PMID: 25127551)

Sunil, V. R. Vayas, K. N. Cervelli, J. A. Malaviya, R. Hall, L. Massa, C. B. Gow, A. J. Laskin, J. D. Laskin, D. L. Pentoxifylline attenuates nitrogen mustard-induced acute lung injury, oxidative stress and inflammation. Exp Mol Pathol, 97:89-98, . (PMID: 24886962)

Mishin, V. Heck, D. E. Laskin, D. L. Laskin, J. D. Human Recombinant Cytochrome P450 Enzymes Display Distinct Hydrogen Peroxide Generating Activities During Substrate Independent NADPH Oxidase Reactions. Toxicol Sci, In process, . (PMID: 25061110)

Lasfar, A. Cook, J. R. Cohen Solal, K. A. Reuhl, K. Kotenko, S. V. Langer, J. Laskin, D. L. Critical Role of the Endogenous IFN Ligand-Receptors in Type I and Type II IFNs Response. Immunology, 142:442-452, . (PMID: 24597649, PMCID: PMC4080960)

Massa, C. B. Scott, P. Abramova, E. Gardner, C. Laskin, D. L. Gow, A. J. Acute chlorine gas exposure produces transient inflammation and a progressive alteration in surfactant composition with accompanying mechanical dysfunction. Toxicol Appl Pharmacol, 278:53-64, . (PMID: 24582687)

Jan, Y. H. Heck, D. E. Dragomir, A. C. Gardner, C. R. Laskin, D. L. Laskin, J. D. Acetaminophen reactive intermediates target hepatic thioredoxin reductase. Chem Res Toxicol, 27:882-894, . (PMID: 24661219, PMCID: PMC4033643)

Malaviya, R. Laskin, J. D. Laskin, D. L. Oxidative stress-induced autophagy: Role in pulmonary toxicity. Toxicol Appl Pharmacol, 275:145-151, . (PMID: 24398106)

Zheng, R. Heck, D. E. Mishin, V. Black, A. T. Shakarjian, M. P. Kong, A. N. Laskin, D. L. Laskin, J. D. Modulation of keratinocyte expression of antioxidants by 4-hydroxynonenal, a lipid peroxidation end product. Toxicol Appl Pharmacol, 275:113-121, . (PMID: 24423726)

Zheng, R. Heck, D. E. Black, A. T. Gow, A. Laskin, D. L. Laskin, J. D. Regulation of keratinocyte expression of stress proteins and antioxidants by the electrophilic nitrofatty acids 9- and 10-nitrooleic acid. Free Radic Biol Med, 67:1-9, . (PMID: 24140437)

Jan, Y. H. Heck, D. E. Malaviya, R. Casillas, R. P. Laskin, D. L. Laskin, J. D. Cross-Linking of Thioredoxin Reductase by the Sulfur Mustard Analogue Mechlorethamine (Methylbis(2-chloroethyl)amine) in Human Lung Epithelial Cells and Rat Lung: Selective Inhibition of Disulfide Reduction but Not Redox Cycling. Chem Res Toxicol, 27:61-75, . (PMID: 24274902, PMCID: PMC4070429)

Groves, A. M. Gow, A. J. Massa, C. B. Hall, L. Laskin, J. D. Laskin, D. L. Age-related increases in ozone-induced injury and altered pulmonary mechanics in mice with progressive lung inflammation. Am J Physiol Lung Cell Mol Physiol, 305:L555-L568, . (PMID: 23997172, PMCID: PMC3798776)

Zheng, R. Po, I. Mishin, V. Black, A. T. Heck, D. E. Laskin, D. L. Sinko, P. J. Gerecke, D. R. Gordon, M. K. Laskin, J. D. The generation of 4-hydroxynonenal, an electrophilic lipid peroxidation end product, in rabbit cornea organ cultures treated with UVB light and nitrogen mustard. Toxicol Appl Pharmacol, 272:345-355, . (PMID: 23845594)

Yang, S. Jan, Y. H. Gray, J. P. Mishin, V. Heck, D. E. Laskin, D. L. Laskin, J. D. Sepiapterin reductase mediates chemical redox cycling in lung epithelial cells. J Biol Chem, 288:19221-19237, . (PMID: 23640889, PMCID: PMC3696693)

Sunil, V. R. Vayas, K. N. Massa, C. B. Gow, A. J. Laskin, J. D. Laskin, D. L. Ozone-induced injury and oxidative stress in bronchiolar epithelium are associated with altered pulmonary mechanics. Toxicol Sci, 133:309-319, . (PMID: 23492811, PMCID: PMC3663562)

D'Addio, S. M. Baldassano, S. Shi, L. Cheung, L. Adamson, D. H. Bruzek, M. Anthony, J. E. Laskin, D. L. Sinko, P. J. Prud'homme, R. K. Optimization of cell receptor-specific targeting through multivalent surface decoration of polymeric nanocarriers. J Control Release, 168:41-49, . (PMID: 23419950, PMCID: PMC3662248)

Liu, Y. Gardner, C. R. Laskin, J. D. Laskin, D. L. Classical and alternative activation of rat hepatic sinusoidal endothelial cells by inflammatory stimuli. Exp Mol Pathol, 94:160-167, . (PMID: 23103612, PMCID: PMC3562401)

Kutscher, H. L. Gao, D. Li, S. Massa, C. B. Cervelli, J. Deshmukh, M. Joseph, L. B. Laskin, D. L. Sinko, P. J. Toxicodynamics of rigid polystyrene microparticles on pulmonary gas exchange in mice: Implications for microemboli-based drug delivery systems. Toxicol Appl Pharmacol, 266:214-223, . (PMID: 23142466, PMCID: PMC3586786)

Malaviya, R. Venosa, A. Hall, L. Gow, A. J. Sinko, P. J. Laskin, J. D. Laskin, D. L. Attenuation of acute nitrogen mustard-induced lung injury, inflammation and fibrogenesis by a nitric oxide synthase inhibitor. Toxicol Appl Pharmacol, 265:279-291, . (PMID: 22981630, PMCID: PMC3516137)

Dragomir, A. C. Sun, R. Choi, H. Laskin, J. D. Laskin, D. L. Role of galectin-3 in classical and alternative macrophage activation in the liver following acetaminophen intoxication. J Immunol, 189:5934-5941, . (PMID: 23175698, PMCID: PMC3518653)

Groves, A. M. Gow, A. J. Massa, C. B. Laskin, J. D. Laskin, D. L. Prolonged Injury and Altered Lung Function after Ozone Inhalation in Mice with Chronic Lung Inflammation. Am J Respir Cell Mol Biol, 47:776-783, . (PMID: 22878412)

Deshmukh, M. Kutscher, H. L. Gao, D. Sunil, V. R. Malaviya, R. Vayas, K. Stein, S. Laskin, J. D. Laskin, D. L. Sinko, P. J. Biodistribution and renal clearance of biocompatible lung targeted poly(ethylene glycol) (PEG) nanogel aggregates. J Control Release, 164:65-73, . (PMID: 23041417)

Sunil, V. R. Patel-Vayas, K. Shen, J. Laskin, J. D. Laskin, D. L. Classical and alternative macrophage activation in the lung following ozone-induced oxidative stress. Toxicol Appl Pharmacol, 263:195-202, . (PMID: 22727909)

Gardner, C. R. Hankey, P. Mishin, V. Francis, M. Yu, S. Laskin, J. D. Laskin, D. L. Regulation of alternative macrophage activation in the liver following acetaminophen intoxication by stem cell-derived tyrosine kinase. Toxicol Appl Pharmacol, 262:139-148, . (PMID: 22575169, PMCID: PMC3377817)

Dragomir, A. C. Sun, R. Mishin, V. Hall, L. B. Laskin, J. D. Laskin, D. L. Role of galectin-3 in acetaminophen-induced hepatotoxicity and inflammatory mediator production. Toxicol Sci, 127:609-619, . (PMID: 22461450, PMCID: PMC3355315)

Sunil, V. R. Shen, J. Patel-Vayas, K. Gow, A. J. Laskin, J. D. Laskin, D. L. Role of reactive nitrogen species generated via inducible nitric oxide synthase in vesicant-induced lung injury, inflammation and altered lung functioning. Toxicol Appl Pharmacol, 261:22-30, . (PMID: 22446026, PMCID: PMC3348344)

Connor, A. J. Laskin, J. D. Laskin, D. L. Ozone-induced lung injury and sterile inflammation. Role of toll-like receptor 4. Exp Mol Pathol, 92:229-235, . (PMID: 22300504)

Gardner, C. R. Mishin, V. Laskin, J. D. Laskin, D. L. Exacerbation of acetaminophen hepatotoxicity by the anthelmentic drug fenbendazole. Toxicol Sci, 125:607-612, . (PMID: 22048645, PMCID: PMC3262853)

Dragomir, A. C. Laskin, J. D. Laskin, D. L. Macrophage activation by factors released from acetaminophen-injured hepatocytes: Potential role of HMGB1. Toxicol Appl Pharmacol, 253:170-177, . (PMID: 21513726)

Kipen, H. M. Gandhi, S. Rich, D. Q. Ohman-Strickland, P. Laumbach, R. Fan, Z. H. Chen, L. Laskin, D. L. Zhang, J. Madura, K. Acute Decreases in Proteasome Pathway Activity after Inhalation of Fresh Diesel Exhaust or Secondary Organic Aerosol. Environ Health Perspect, 119:658-663, . (PMID: 21163722, PMCID: PMC3094417)

Liu, Y. Wei, L. Laskin, D. L. Fanburg, B. L. Role of Protein Transamidation in Serotonin-induced Proliferation and Migration of Pulmonary Artery Smooth Muscle Cells. Am J Respir Cell Mol Biol, 44:548-555, . (PMID: 20558776, PMCID: PMC3095926)

Black, A. T. Gordon, M. K. Heck, D. E. Gallo, M. A. Laskin, D. L. Laskin, J. D. UVB light regulates expression of antioxidants and inflammatory mediators in human corneal epithelial cells. Biochem Pharmacol, 81:873-880, . (PMID: 21300015, PMCID: PMC3345282)