Allan H. Conney, PhD

Director, Susan Lehman Cullman Laboratory for Cancer Research
State of NJ Professor of Pharmacology; William M. and Myrle W. Garbe Professor of Cancer and Leukemia Research; and Professor of Chemical Biology
Rutgers, The State University of New Jersey

School of Pharmacy, Laboratory for Cancer Research
164 Frelinghuysen Road, Room 129
Piscataway, NJ 08855

Phone: (732) 445-4940
Email: aconney@pharmacy.rutgers.edu

Assistant: Annette Dionisio
(732) 445-3400
Email: adio@pharmacy.rutgers.edu

Research Program Alignment

• Carcinogenesis and Chemoprevention Program

Membership Type: Full

Selected Publications

Lu, Y-P., Lou, Y-R., Nolan, B., Peng, Q-Y., Xie, J-G., Wagner, G.C. and Conney, A.H.: Stimulatory effect of voluntary exercise or fat removal (partial lipectomy) on apoptosis in the skin of UVB light-irradiated mice. Proc. Natl. Acad. Sci. (U.S.A), 103: 16301-16306, 2006.

Zheng, X., Cui, X-X. Avila, G.E., Huang, M-T., Liu, Y., Patel, J., Kong, A.N.T., Paulino, R., Shih, W.J., Lin, Y., Rabson, A.B., Reddy, B.S., Conney, A.H.: Atorvastatin and celecoxib inhibit prostate PC-3 tumors in immunodeficient mice. Clin. Cancer Res. 13: 5480-5487, 2007.

Conney, A.H., Zhou, S., Lee M-J., Xie, J-G., Yang, C.S., Lou, Y-R., Lu, Y-P.: Stimulatory effect of oral administration of tea, coffee or caffeine on UVB-induced apoptosis in the epidermis of SKH-1 mice. Toxicol. Appl Pharmacol. 224: 209-213, 2007.

Conney, A.H., Kramata, P., Lou, Y-R., Lu, Y-P.: Effect of caffeine on UVB-induced carcinogenesis, apoptosis, and the elimination of UVB-induced patches of p53 mutant epidermal cells in SKH-1 mice. Photochem. Photobiol. 84: 330-338, 2008.

Lu, Y-P., Lou, Y-R., Peng, Q-Y., Xie, J-G., Nghiem, P., Conney, A.H.: Effect of caffeine on the ATR/Chk1 pathway in the epidermis of UVB-irradiated mice. Cancer Res. 68: 2523-2529, 2008.

Lu, Y-P., Lou, Y-R., Xie, J-G., Peng, Q-Y., Shih, W.J., Lin, Y. and Conney, A.H.: Tumorigenic effect of some commonly used moisturizing creams when applied topically to UVB-pretreated high risk mice. J. Invest. Dermatol., 129: 468-475, 2009.

Zheng, X., Cui, X-X., Gao, Z., Zhao, Y., Lin, Y., Shih, W. J., Huang, M-T., Liu, Y., Rabson, A., Reddy, B., Yang, C. S., and Conney, A. H., Atorvastatin and celecoxib in combination inhibits the progression of androgen-dependent LNCaP xenograft prostate tumors to androgen independence. Cancer Prevention Res. 3: 114-124, 2010.

Zheng, X., Cui, X-X., Zhao, Y., Shi, Y., Huang, M-T., Liu, Y., Wagner, G. C., Lin, Y., Shih, W. J., Rao, C. V., Yang, C. S., and Conney A. H., Inhibitory effect of dietary atorvastatin and celecoxib together with voluntary running wheel exercise on the progression of androgen-dependent LNCaP prostate tumors to androgen independence. Exp. Ther. Med., 2: 221-228, 2011.

Lu, Y-P., Lou, Y-R., Peng, Q-Y, Nghiem, P., and Conney, A. H., Caffeine decreases phospho-Chk1 (Ser317) and increases mitotic cells with cyclin B1 and caspase 3 in tumors from UVB-treated mice. Cancer Prev. Res. 4: 1118-1125, 2011

Lou, Y-R., Peng, Q-Y., Li, T., Medvecky, C.M., Lin, Y., Shih, W.J., Conney, A.H., Shapses, S., Wagner, G.C., and Lu, Y.P., Effects of high-fat diets rich in either omega-3 or omega-6 fatty acids on UVB-induced skin carcinogenesis in SKH-1 mice. Carcinogenesis. 32: 1078-1084, 2011.

Kawasumi, M., Lemos, B., Bradner, J.E., Thibodeau, R., Kim, Y-S., Schmidt, M., Higgins, E., Koo, S-W., Angle-Zahn, A., Chen, A., Levine, D., Nguyen, L., Heffernan, T.P., Longo, I., Mandinova, A., Lu, Y-P., Conney, A.H., and Nghiem, P., Protection from UV-induced skin carcinogenesis by genetic inhibition of the ataxia telangiectasia and Rad3-related (ATR) kinase. Proc. Natl. Acad. Sci. (U.S.A.) 108: 13716-13721, 2011.

Zheng, X., Cui, X-X., Khor, T.O., Huang, Y., DiPaola, R.S., Goodin, S., Lee, M-J. Yang, C.S. Kong, A.N. and Conney, A.H., Inhibitory effect of a γ-tocopherol-rich mixture of tocopherols on the formation and growth of LNCaP prostate tumors in immunodeficient mice. Cancers 3: 3762-3772, 2011.

Conney, A. H. and Reidenberg, M. M., Perspectives in pharmacology: Cigarette smoking, coffee drinking, and ingestion of charcoal-broiled beef as potential modifiers of drug therapy and confounders of clinical trials. J. Pharmacol. Exp. Ther. 342: 9-14, 2012

Lu, Y-P., Lou, Y-R., Bernard, J. J., Peng, Q-Y., Li, T., Lin, Y., Shih, W. J., Nghiem, P., Shapses, S., Wagner, G. C. and Conney, A. H., Surgical removal of the parametrial fat pads stimulates apoptosis and inhibits UVB-induced carcinogenesis in mice fed a high fat diet. Proc. Natl. Acad. Sci. (U.S.A.) 109: 9065-9070, 2012.

Wei, X., Du, Z-Y., Zheng, X., Cui, X-X., Conney, A.H., and Zhang, K., Synthesis and evaluation of curcumin-related compounds for anticancer activity. Eur. J. Med. Chem. 53: 235-245, 2012.