Arnold Levine, PhD Co-Leader, Genomic Instability and Tumor Progression Research Program Professor of Pediatrics; and Biochemistry and Molecular Biology Robert Wood Johnson Medical School Cancer Institute of New Jersey 195 Little Albany Street New Brunswick, NJ 08901-1914 Email: alevine@ias.edu Assistant: Jane C. Reid (609) 734-8254 Email: jcreid@ias.edu

Research Program Alignment

• Genomic Instability and Tumor Progression Program

Membership Type: Full

Selected Publications

Elowitz, M.B., Levine, A.J., Siggia, E.D., Swain, P.S. Stochastic Gene Expression in a Single Cell. Science, 297:1183-1186 (2002).

Hoh, J. Jin, S., Parrado, T., Edington, J., Levine, A.J., Ott, J.The p53 MA Algorithm and its Application in Detecting p53 Responsive Genes. PNAS USA, 99: 8467-8472 (2002).

Atwal, G.S., Bond, G.L., Metsuyanim, S., Papa, M., Friedman, E., Distelman-Menachem, T., Asher, E.B., Lancet, D., Ross, D.A., Sninsky, J., White, T.J., Levine, A.J., and Yarden, R. Haplotype structure and selection of the MDM2 oncogene in humans, PNAS, 104(11), 4524-4529 (2007).

Hu, W., Feng, Z., Ma, L., Wagner, J., Rice, J.J., Stolovitzky, G., and Levine, A.J. A single nucleotide polymorphism in the MDM2 gene disrupts the oscillation of p53 and MDM2 levels in cells, Cancer Research, 67(6), 2757-2765 (2007).

Atwal, G.S., Rabadán, R., Lozano, G., Strong, L., Ruijs, M., Schmidt, M., van’t Veer, L., Nevanlinna, L., Tommiska, J., Aittomaki, K., Bougeard, G., Frebourg, T., Levine, A.J., Bond, G. An Information-Theoretic Analysis of Genetics, Gender and Age in Cancer Patients. PLoS One (2008). PMCID: PMC2276689

Hey-Joo Kang, Zhaohui Feng, Yvonne Sun, Gurinder Atwal, Maureen E. Murphy, Timothy R. Rebbeck, Zev Rosenwaks, Arnold J. Levine, Wenwei Hu, 2009. Single nucleotide polymorphisms in the p53 pathway regulate fertility in humans. PNAS 2009, 106:9761-9766. PMCID: PMC2700980

Atwal, GS, Kirchhoff, T., Bond,  E.E., Montagna, M., Menin, C., Bertorelle, R., Scaini, M.C., Bartel, F., Böhnke, A., Pempe, C., Gradhand, E., Hauptmann, S., Offit, K., Levine, A.J, Bond, G.L, 2009. Altered tumor formation and evolutionary selection of genetic variants in the human MDM4 oncogene. PNAS 2009, 106 (25):10236-41 PMCID PMC2700939

Hu W, Zhang C, Wu R, Sun Y, Levine A, Feng Z, Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function. PNAS 107 (16):7455-7460 (2010).

Nicolau, M., Levine, A.J., and Carlsson, G.  2011 Topology based data analysis identifies a subgroup of breast cancers with a unique mutational profile and excellent survival. PNAS 2011 April 26;108 (17) :7265-70. Epub 2011 Apr 11. PMCID: PMC3084136

Levine, A.J., Tomasini, R., McKeon, F.D., Mak, T.W.  Melino, G., The p53 family: guardians of maternal reproduction. Nature Reviews Molecular Cell Biology, April 2011, 12:259-265

Zhaohui Feng, Wenwei Hu, Arnold J. Levine, Meihua Lin, Xiaowen Wang, Rui Wu, Bo Yang, Cen Zhang, Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect. PNAS. 2011 Sep 27;108(39):16259-64. Epub 2011 Sep 19.

Markert E. K., Mizuno H., Vazquez A., Levine A. J. Molecular classification of prostate cancer using curated expression signatures. PNAS 2011 Dec 27;108(52):21276 21281.  Published online 2011 November 28. PMCID: PMC3248553

Freed-Pastor WA, Mizuno H, Zhao X, Langerød A, Moon SH, Rodriguez-Barrueco R, Barsotti A, Chicas A, Li W, Polotskaia A, Bissell MJ, Osborne TF, Tian B, Lowe SW, Silva JM, Børresen-Dale AL, Levine AJ, Bargonetti J, Prives C. Mutant p53 Disrupts Mammary Acinar Morphogenesis via the Mevalonate Pathway, Cell. 2012 Jan 20;148 (1-2):244-58.

Feng Z, Liu L, Zhang C, Zheng T, Wang J, Lin M, Zhao Y, Wang X, Levine AJ, Hu W. Chronic restraint stress attenutates p53 function and promotes tumorigenesis. PNAS. 2012 May 1;109(18):7013-8. Epub 2012 Apr 16. PMCID: PMC3345015

Xin Yu,  Alexei Vazquez, Arnold J. Levine, Darren R. Carpizo. Allele-Specific p53 Mutant Reactivation. Cancer Cell, 2012 May 15; 21 (5): 614-625. PMCID: PMC3366694