Researcher Profile

J. Don Chen, PhD

Professor of Pharmacology
Robert Wood Johnson Medical School
Rutgers, The State University of New Jersey

Staged Research Buidling
661 Hoes Lane West, Room 140
Piscataway, NJ 08854

Phone: (732) 235-3292
Email: chenjd@rwjms.rutgers.edu

Research Program Alignment

  • Non-programmatically Aligned

Membership Type: Associate II


Research Interests

  • Molecular mechanisms of cancer regulated by steroid/nuclear hormone receptors
  • Identification of new genes that control nuclear receptor function to identify targets for treating nuclear receptor-related human diseases such as acute promyelocytic leukemia, breast/prostate cancer, and diabetes and to provide insight into mechanisms of drug resistance.

Selected Publications

Chen, J. D. & Pirrotta, V. (1993) Multimerization of the Drosophila Zeste Protein is Required for Efficient DNA Binding. EMBO J., 12: 2075-2083.

Yao, T.-P., Forman, B.M., Jiang, Z., Cherbas, L., Chen, J. D., Mckeown, M., Cherbas, P. & Evans, R.M. (1994) The Functional and Pharmacologic Ecdysone Receptor is the Product of the ECR and Ultraspiracle Genes. Nature, 366: 476-479.

Dyck, J.A., Maul, G., Miller, W.H. Jr., Chen, J. D., Kakizuka, A. & Evans, R.M. (1994) A Novel Macromolecular Structure is a Target of the PML-RAR Oncoprotein. Cell, 76: 333-343.

Chen, J. D. & Evans, R. M. (1995) A Transcriptional Co-Repressor that Interacts with Nuclear Hormone Receptors.  Nature, 377: 454-457.

Chen, J. D. Umesono, K. & Evans, R.M. (1996) SMRT Isoforms Mediate Repression and Anti-repression of Nuclear Receptor Heterodimers. Proc. Natl. Acad. Sci. USA 93: 7567-7571.

Li, H., Gomes, P. & Chen, J.D. (1997) RAC3, a Steroid/Nuclear Receptor Coactivator that is Related to SRC-1 and TIF2. Proc. Natl. Acad. Sci. USA 94: 8479-8484.

Park, E-J., Schroen, D.J., Yang, M., Li, H., Li, L., & Chen, J.D. (1999) SMRTe, a Silencing Mediator for Retinoid and Thyroid Hormone Receptors-extended Isoform that is More Related to the Nuclear Receptor Corepressor.  Proc. Natl. Acad. Sci. USA 96: 3519-3524.

Li, H., Leo, C., Zhu, J., Wu, X., O’Neil, J., Park, E-J. & Chen, J.D. (2000) Sequestration and Inhibition of Daxx-mediated Transcriptional Repression by PML. Mol. Cell. Biol., 20: 1784-1796.

Chisamore, M.J., Wilkinson, H.A., Flores, O., and Chen, J.D. (2009) Estrogen-related receptor-{alpha} antagonist inhibits both estrogen receptor-positive and estrogen receptor-negative breast tumor growth in mouse xenografts. Mol. Cancer Ther., 8: 672-681.

Li, C.-W., Dinh, G.K., and Chen, J.D. (2009) Preferential physical and functional interaction of pregnane X receptor with the SMRTalpha isoform. Mol. Pharmacol., 75: 363-373.

Chisamore MJ, Cunningham ME, Flores O, Wilkinson HA, Chen JD. (2009) Characterization of a novel small molecule subtype specific estrogen-related receptor alpha antagonist in MCF-7 breast cancer cells. PLoS ONE. 4(5):e5624.

Lin YS, Yasuda K, Assem M, Cline C, Barber J, Li CW, Kholodovych V, Ai N, Chen JD, Welsh WJ, Ekins S, Schuetz EG. (2009) The major human pregnane X receptor (PXR) splice variant, PXR.2, exhibits significantly diminished ligand-activated transcriptional regulation. Drug Metab Dispos. 37(6):1295-304.

Li CW, Dinh GK, Chen JD. (2009) Preferential physical and functional interaction of pregnane X receptor with the SMRTalpha isoform. Mol Pharmacol. 75(2):363-73.

Neilsen PM, Cheney KM, Li CW, Chen JD, Cawrse JE, Schulz RB, Powell JA, Kumar R, Callen DF. (2008) Identification of ANKRD11 as a p53 coactivator. J Cell Sci. 121(Pt 21):3541-52.

Li CW, Dinh GK, Zhang A, Chen JD. (2008) Ankyrin repeats cofactors interact with ADA3 and modulate its coactivator function. Biochem J. 413(2):349-57.

The content for this Research Profile is maintained by Paul Novembre (novembre@cinj.rutgers.edu)