Researcher Profile

Shengkan (Victor) Jin, PhD

Associate Professor of Pharmacology
Robert Wood Johnson Medical School
Rutgers, The State University of New Jersey

RWJMS Research Tower
675 Hoes Lane West, 4th Floor
Piscataway, NJ 08854

Phone: (732) 235-4329
Email: jinsh@rutgers.edu

Assistant: Lucyna Lis
(732) 235-5526
Email: lislu@rutgers.edu

Research Program Alignment

Membership Type: Associate


Research Interests

  • Autophagy in cancer and cancer intervention
  • Cancer cell metabolism
  • Autophagy in adipose differentiation and metabolic diseases
  • Alteration of cellular metabolism as a strategy for prevention and treatment of cancer and metabolic diseases

Selected Publications

Taylor R., Chen, P-H., Chou, C-C., Patel, J. and Jin, S. KCS1 deletion in Saccharomyces Cerevisiae leads to a defect in translocation of autophagic proteins and reduces autophagosome formation. Autophagy 8(9): 1-12, 2012.

Moloughney, JG., Monken, CE., Tao, H., , Zhang H., Thomas, JD., Lattime, EC., and Jin, S. Vaccinia virus leads to ATG12-ATG3 conjugation and deficiency in autophagosome formation. Autophagy 7(12): 1434 - 1447, 2011.

Goldman, SJ., Chen, E., Taylor, R., Petrosky, W., Reiss, M., and Jin, S. Use of the ODD-luciferase transgene for the non-invasive imaging of spontaneous tumors in mice. PLoS One. 6(3):e18269, 2011.

Yong Zhang, Scott Goldman, Rebecca Baerga, Yun Zhao, Masaaki Komatsu, and Shengkan Jin. Adipose-Specific Deletion of the Autophagy-Related Gene 7 (atg7) reveals a Role in Adipogenesis. Proc. Nat. Acad. Sci. 106(47):19860-5. 2009

Rebecca Baerga, Yong Zhang, Po-Hao Chen, Scott Goldman, and Shengkan Jin. Targeted Deletion of autophagy-related 5 (atg5) Impair WAT Adipogenesis in a Cell Culture Model and in Mice. Autophagy: 5(8):1118-30. 2009

Karantza-Wadsworth V, Patel S, Kravchuk O, Chen G, Mathew R, Jin S, White E. Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. Genes and Dev. 21(13):1621-35, 2007

Zhang Y, Qi H, Taylor R, Xu W, Liu LF, Jin S. The Role of Autophagy in Mitochondria Maintenance: Characterization of Mitochondrial Functions in Autophagy-Deficient S. cerevisiae Strains. Autophagy. 9;3(4):337-346, 2007

Mathew R, Kongara S, Beaudoin B, Karp CM, Bray K, Degenhardt K, Chen G, Jin S, White E. Autophagy suppresses tumor progression by limiting chromosomal instability. Genes and Dev. 21(11):1367-81, 2007

Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ. The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways. Cancer Res. 67(7):3043-53, 2007

Eszter S. Hars, Haiyan Qi, Shengkan Jin, Li Cai, Chengcheng Hu and Leroy F. Liu. Autophagy Regulates Ageing in C. elegans. Autophagy. 3(2):93-5, 2007

Degenhardt, K., Mathew, R., Beaudoin, B., Bray, K., Anderson, D, Chen, G., Mukherjee, C., Shi, Y., Nelson, D.A., Jin, S., and White, E. Autophagy Promotes Tumor cell Survival and Restricts Necrosis, Inflammation, and Tumorigenesis. Cancer Cell. 10(1):51-64, 2006

Haiyan Zhang, Claude E. Monken, John Lenard, Noboru Mizushima, Edmund C. Lattime, and Shengkan Jin. Cellular Autophagy Machinery is not Required for Vaccinia Virus Replication and Maturation. Autophagy, 2(2): 91-95, 2006

Changyou Li, Elizabeth Capan, Yani Zhao, Jianping Zhao, Donna Stolz, Simon C. Watkins, Shengkan Jin and Binfeng Lu. Autophagy is induced in CD4+ T cells and important for the growth factor-withdrawal cell death. J. Immunology. 177(8):5163-8, 2006

Wu H, Yang JM, Jin S, Zhang H, and Hait WN. Elongation factor-2 kinase regulates autophagy in human glioblastoma cells. Cancer Research. 66(6):3015-23, 2006

Zhaohui Feng, Shengkan Jin*, A. Zupnick, J. Hoh, E. de Stanchina, S. Lowe, C. Prives, and Arnold J. Levine. p53 tumor suppressor protein regulates the levels of huntingtin gene expression. (*S.J. is an equal contribution first author). Oncogene. 25(1):1-7, 2006

The content for this Research Profile is maintained by Paul Novembre (novembre@cinj.rutgers.edu)