John E. Kerrigan, PhD Associate Director of Bioinformatics Shared Resource, CINJ Adjunct Associate Professor of Pharmacology Robert Wood Johnson Medical School Cancer Institute of New Jersey 120 Albany Street, Tower II New Brunswick, NJ 08901 Phone: (732) 235-4473 Email: kerrigje@umdnj.edu

Research Program Alignment

• Cancer Pharmacology and Pre-clinical Therapeutics Program

Membership Type: Associate - CCSG

Selected Publications

Plaskon, R.R.; Kam, C.; Kerrigan, J.E.; Burgess, E.M.; Powers, J.C.; Suddath, F.L. "Inhibition of PPE by 7-Substituted-4-Chloro-3-Ethoxyisocoumarins: Structural Characteristics of Modeled Noncovalent Complexes Relate to the Measured Inhibition Kinetics", Archives of Biochemistry and Biophysics 1993, 300, 588-597.

Kam, C.; Kerrigan, J.E.; Plaskon, R.; Duffy, E.J.; Lollar, P.; Suddath, F.L.; Powers, J.C. "Mechanism-Based Isocoumarin Inhibitors for Blood Coagulation Serine Proteases.  Effect of the 7-Substituent in 7-Amino-4-chloro-3-isothiureidoalkoxyisocoumarin Derivatives on Inhibitory and Anticoagulant Potency", J. Med. Chem. 1994, 37, 1298-1306.

Kerrigan, J.E.; Oleksyszyn, J.; Kam, C.-M.; Selzler, J.; Powers, J.C. "Mechanism-Based Inhibitors for Human Leukocyte Elastase.  Effect of the 7-Amino Substituent and 3-Alkoxy Group in 7-Amino-4-chloro-3-alkoxyisocoumarins on Inhibitory Potency ", J. Med. Chem. 1995, 38, 544-552.

Frew, T.; Powis, G.; Bergeren, M.; Gallegos, A.; Abraham, R. T.; Ashendel, C. L.; Zalkow, L. H.; Hudson, C.; Gruszecka-Kowalik, E.; Burgess, E. M.; Benedetti-Doctorovich, V. ; Kerrigan, J. E. ; Lambropoulos, J. ; Merriman, R. ; Bonjouklian, R. “Novel quinone antiproliferative inhibitors of phosphatidylinositol-3-kinase” Anti Canc. Drug Des. (now Oncology Res.) 1995, 10(4), 347-359.

Kerrigan, J.E.; Walters, M.C.; Forrester, K.J.; Crowder, J.B.; Christopher, L.J. “6-Acylamino-2-[(alkylsulfonyl)oxy]-1-H-isoindole-1,3-dione Mechanism-Based Inhibitors of Human Leukocyte Elastase” Bioorg. Med. Chem. Lett. 2000, 10, 27-30.

Vagnoni, L.M.; Gronostaj, M; Kerrigan, J.E. “6-Acylamino-2-[(ethylsulfonyl)oxy]-1H-isoindole-1,3-dione Mechanism-Based Inhibitors of Human Leukocyte Elastase and Cathepsin G.  Effect of Chirality in the 6-Acylamino Substituent on Inhibitory Potency and Selectivity.” Bioorg. Med. Chem. 2001, 9(3), 637-645.

Kerrigan, J.E.; Pilch, D.S. “A Structural Model for the Ternary Cleavable Complex Formed Between Human Toposiomerase I, DNA, and Camptothecin.” Biochemistry 2001, 40, 9792-9798.

Kerrigan, J.E.; Pilch, D.S.; Ruchelman, A.L.; Zhou, N.; Liu, A.; Liu, L.; LaVoie, E.J. “5H-8,9-Dimethoxy-5(2-N,N-dimethylaminoethyl)dibenzol[c,h][1,6]naphthyridin-6-ones and Related Compounds as TOP1-Targeting Agents: Influence of Structure on the Ternary Cleavable Complex Formation” Bioorg. Med. Chem. Lett. 2003, 13(20), 3395-3399.

Ruchelman, A.; Kerrigan, J.E.; Li, T.; Zhou, N.; Liu, A.; Liu, L.F.; LaVoie, E.J. “Nitro and Amino Substitution within the A-ring of 5H-8,9-Dimethyoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: Influence on Topoisomerase I-Targeting Activity and Cytotoxicity” Bioorg. Med. Chem. 2004, 12, 3731-3742

Wu, W.; Kerrigan, J.E.; Yadav, P.; Schwartz, B.; Izotova, L.; Lavoie, T.; Pestka, S. "Design and Construction of a Phosphorylatable Chimeric Monoclonal Antibody with a Highly Stable Phosphate" Oncology Research, 2004, 14 (11/12), 541-558.

Moyle, W.R.; Xing, Y.; Lin, W.; Cao, D.; Myers, R.V.; Kerrigan, J.E.; Bernard, M.P. "Model of Glycoprotein Hormone Receptor Ligand Binding and Signaling" J. Biol. Chem., 2004, 279(43), 44442-44459.

Moyle, W.R.; Lin, W.; Myers, R.V.; Cao, D.; Kerrigan, J.E.; Bernard, M.P. "Models of glycoprotein hormone receptor interaction." Endocrine, 2005, 26(3), 189-205.

Minhas, G.; Pilch, D.S.; Kerrigan, J.E.; LaVoie, E.J.; Rice, J.R. "Synthesis and G-Quadruplex Stabilizing Properties of a Series of Oxazole-Containing Macrocycles" Bioorg. Med. Chem. Lett. 2006, 16, 3891-3895.

Lin, W.; Bernard, M.P.; Cao, D.; Myers, R.V.; Kerrigan, J.E.; Moyle, W.R. "Follitropin Receptors Contain Cryptic Ligand Binding Sites" Mol. Cell. Endocrinol. 2007, 260-262, 83-92.

Perez, L; Kerrigan, J.E.; Li, X.; Fan, H. “Substitution of Methionine-435 in Tumor Necrosis Factor-alpha Converting Enzyme with Leucine, Isoleucine and Serine Inactivates Ectodomain Shedding Activity” Biochem. Cell Biol. 2007, 85, 141-149.