Eduardo D. Sontag, PhD
Member since December 29, 2008
Distinguished Professor of Mathematics and Distinguished Professor, BioMaPS Institute for Quantitative Biology
School of Arts and Sciences
Rutgers, The State University of New Jersey
Graduate Faculty, Electrical and Computer Engineering; Graduate Faculty, Computer Science; Director, Rutgers Undergraduate Biomathematics Major; Director, Center for Systems and Control
Phone: (732) 445-2390
Hill Center for Mathematical Sciences
110 Frelinghuysen Road, Room 724, Busch Campus
Piscataway, NJ 08854-8019
- Interested in all aspects of "systems biology", including especially cell signaling and development. Most of my work concerns dynamical system behavior, including control and signal-processing aspects. Examples include my work on oscillations in cell-cycle and circadian models, multi-stability of MAPK cascades, and models of gene networks. However, my current research also includes aspects from computational biology such as TF binding site recognition and analysis of interaction networks.
M. Margaliot, E.D. Sontag, and T. Tuller. Entrainment to periodic initiation and transition rates in a computational model for gene translation. PLoS ONE, 9(5):e96039, 2014.
S. Prabakaran, J. Gunawardena, and E.D. Sontag. Paradoxical results in perturbation-based signaling network reconstruction. Biophysical Journal, 106:2720-2728, 2014.
M. Skataric, E.V. Nikolaev, and E.D. Sontag. A fundamental limitation to fold-change detection by biological systems with multiple time scales. IET Systems Biology, To appear, 2014.
T.H. Segall-Shapiro, A.J. Meyer, E.D. Sontag, A.D. Ellington, and C.A. Voigt. A 'resource allocator' for transcription based on a highly fragmented T7 RNA polymerase. Nature Molecular Systems Biology, To appear, 2014.
J. Barton and E.D. Sontag. The energy costs of insulators in biochemical networks. Biophysical Journal, 104:1390-1380, 2013.
A.O. Hamadeh, B.P. Ingalls, and E.D. Sontag. Transient dynamic phenotypes as criteria for model discrimination: fold-change detection in Rhodobacter sphaeroides chemotaxis. Proc. Royal Society Interface, 10:20120935, 2013.
T. Kang, J.T. White, Z. Xie, Y. Benenson, E.D. Sontag, and L. Bleris. Reverse engineering validation using a benchmark synthetic gene circuit in human cells. ACS Synthetic Biology, 2:255-262, 2013.
L. Liu, G. Duclos, B. Sun, J. Lee, A. Wu, Y. Kam, E.D. Sontag, H.A. Stone, J.C. Sturm, R.A. Gatenby, and R.H. Austin. Minimization of thermodynamic costs in cancer cell invasion. Proc Natl Acad Sci USA, 110:1686-1691, 2013.
V. Shimoga, J.T. White, Y. Li, E.D. Sontag, and L. Bleris. Synthetic mammalian transgene negative autoregulation. Nature Molecular Systems Biology, 9:670-, 2013.
M. Miller, M. Hafner, E.D. Sontag, N. Davidsohn, S. Subramanian, P. E. M. Purnick, D. Lauffenburger, and R. Weiss. Modular design of artificial tissue homeostasis: robust control through synthetic cellular heterogeneity. PLoS Computational Biology, 8:e1002579-, 2012.
K. Wood, S. Nishida, E.D. Sontag, and P. Cluzel. Mechanism-independent method for predicting response to multiple drug exposure in bacteria. Proc Natl Acad Sci USA, 109:12254-12259, 2012.
O. Shoval, L. Goentoro, Y. Hart, A. Mayo, E.D. Sontag, and U. Alon. Fold change detection and scalar symmetry of sensory input fields. Proc Natl Acad Sci USA, 107:15995-16000, 2010.
G. Russo, M. di Bernardo, and E.D. Sontag. Global entrainment of transcriptional systems to periodic inputs. PLoS Computational Biology, 6:e1000739, 2010.
A.M. Weinstein and E.D. Sontag. Modeling proximal tubule cell homeostasis: Tracking changes in luminal flow. Bulletin of Mathematical Biology, 71:1285-1322, 2009.
T. Riley, X. Yu, E.D. Sontag, and A. Levine. The P53HMM algorithm: using novel profile Hidden Markov Models to detect p53-responsive genes. BMC Bioinformatics, 10:111, 2009.
T. Riley, E.D. Sontag, P. Chen, and A. Levine. The transcriptional regulation of human p53-regulated genes. Nature Reviews Molecular Cell Biology, 9:402-412, 2008.
D. Angeli, J. E. Ferrell, and E.D. Sontag. Detection of multistability, bifurcations, and hysteresis in a large class of biological positive-feedback systems. Proc Natl Acad Sci USA, 101(7):1822-1827, 2004.
E.D. Sontag, A. Kiyatkin, and B.N. Kholodenko. Inferring dynamic architecture of cellular networks using time series of gene expression, protein and metabolite data. Bioinformatics, 20(12):1877-1886, 2004.
M. Chaves, R.J. Dinerstein, and E.D. Sontag. Optimal length and signal amplification in weakly activated signal transduction cascades. J. Physical Chemistry, 108:15311-15320, 2004.
J. R. Pomerening, E.D. Sontag, and J. E. Ferrell. Building a cell cycle oscillator: hysteresis and bistability in the activation of cdc2. Nature Cell Biology, 5(4):346-351, 2003.
E.D. Sontag. Structure and stability of certain chemical networks and applications to the kinetic proofreading model of T-cell receptor signal transduction. IEEE Trans. Automat. Control, 46(7):1028-1047, 2001.
The content for this Researcher Profile is maintained by Paul Novembre (firstname.lastname@example.org)