Researcher Profile

Kosaku Iwatsubo, MD, PhD

Associate II Member, Cancer Metabolism and Growth Program

Member since 2011

Academic Appointment

Assistant Professor of Cell Biology and Molecular Medicine
New Jersey Medical School
Rutgers, The State University of New Jersey

Research Interests

  • Our laboratory studies the function of exchange protein directly activated by cAMP (Epac)-1 in melanoma progression. We have found that expression of Epac1 is higher in metastatic melanoma than in primary melanoma. Human melanoma cell lines demonstrated that Epac1 significantly increases cell migration. The mechanisms underlying Epac1-induced cell migration involves modification of heparan sulfate, and regulation of calcium homeostasis. Our goal in this project is understating molecular mechanism(s) of Epac1-meidated melanoma metastasis, and developing a small molecule(s) that can inhibit Epac1, leading a novel therapy for melanoma.

Selected Publications

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