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Endogenous Retrovirus Expression, Chromatin Abnormalities and Response to Immune Checkpoint Blockade in Clear Cell Renal Cell Cancer.
We propose an alternative mechanism of immune activation that may be relevant in low mutation burden cancers such as ccRCC: re-expression of repetitive RNA elements including endogenous retroviruses (ERV).
Protocol Number:
081909
Phase:
N/A
Applicable Disease Sites:
Other Urinary
Principal Investigator:
Shridar Ganesan MD, PhD
Scope:
Local
Participating Institutions:
- Rutgers Cancer Institute of New Jersey
For further information about clinical trials, please contact us at 732-235-7356.