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Kim Laboratory - Select Publications

Na JC, Nagaya N, Rha KH, Han WK, Kim IY. DNA Damage Response Pathway Alteration in Locally Advanced Clear-Cell Renal-Cell Carcinoma Is Associated With a Poor Outcome. Clin Genitourin Cancer. 2019 Aug;17(4):299-305.e1. doi: 10.1016/j.clgc.2019.05.004. Epub 2019 May 21. PMID:31204211

Lee GT, Kim JH, Kwon SJ, Stein MN, Hong JH, Nagaya N, Billakanti S, Kim MM, Kim WJ, Kim IY. Dihydrotestosterone Increases Cytotoxic Activity of Macrophages on Prostate Cancer Cells via TRAIL. Endocrinology. 2019 Sep 1;160(9):2049-2060. doi: 10.1210/en.2019-00367. PMID:31184711

Lee GT, Kwon SJ, Kim J, Kwon YS, Lee N, Hong JH, Jamieson C, Kim WJ, Kim IY. WNT5A induces castration-resistant prostate cancer via CCL2 and tumour-infiltrating macrophages. Br J Cancer. 2018;118(5):670-678. PMID: 29381686; PMCID: PMC5846063.

Lee GT, Han CS, Kwon YS, Patel R, Modi PK, Kwon SJ, Faiena I, Patel N, Singer EA, Ahn HJ, Kim WJ, Kim IY. Intracrine androgen biosynthesis in renal cell carcinoma. Br J Cancer. 2017;116(7):937-943. PMID: 28253524; PMCID: PMC5379152.

Ha YS, Lee GT, Modi P, Kwon YS, Ahn H, Kim WJ, Kim IY. Increased expression of androgen receptor mRNA in human renal cell carcinoma cells is associated with poor prognosis in patients with localized renal cell carcinoma. J Urol. 2015;194(5):1441-8. PMID: 25796113. 

Lee GT, Kang DI, Ha YS, Jung YS, Chung J, Min K, Kim TH, Moon KH, Chung JM, Lee DH, Kim WJ, Kim IY. Prostate cancer bone metastases acquire resistance to androgen deprivation via WNT5A-mediated BMP-6 induction. Br J Cancer. 2014;110(6):1634-44. PMID:24518599; PMCID: PMC3960605. 

Lee GT, Ha YS, Jung YS, Moon SK, Kang HW, Lee OJ, Joung JY, Choi YH, Yun SJ, Kim WJ, Kim IY. DHCR24 is an independent predictor of progression in patients with non-muscle-invasive urothelial carcinoma, and its functional role is involved in the aggressive properties of urothelial carcinoma cells. Ann Surg Oncol. 2014;21 Suppl 4:S538-45. PMID: 24562935. 

Kwon SJ, Lee GT, Lee JH, Iwakura Y, Kim WJ, Kim IY. Mechanism of pro-tumorigenic effect of BMP-6: neovascularization involving tumor-associated macrophages and IL-1a. Prostate. 2014;74(2):121-33. PMID: 24185914. 

Lee JH, Lee GT, Woo SH, Ha YS, Kwon SJ, Kim WJ, Kim IY. BMP-6 in renal cell carcinoma promotes tumor proliferation through IL-10-dependent M2 polarization of tumor-associated macrophages. Cancer Res. 2013;73(12):3604-14. 

Lee GT, Jung YS, Ha YS, Kim JH, Kim WJ, Kim IY. Bone morphogenetic protein-6 induces castration resistance in prostate cancer cells through tumor infiltrating macrophages. Cancer Sci. 2013 Aug;104(8):1027-32. PMID: 23710822.

Lee JH, Lee GT, Kwon SJ, Jeong J, Ha YS, Kim WJ, Kim IY. CREBZF, a novel Smad8-binding protein. Mol Cell Biochem. 2012;368(1-2):147-53. PMID: 24708639. PMCID: PMC4005471. 

Lee GT, Jung YS, Lee JH, Kim WJ, Kim IY. Bone morphogenetic protein 6-induced interleukin-1β expression in macrophages requires PU.1/Smad1 interaction. Mol Immunol. 2011;48(12-13):1540-7. PMID: 21571370. 

Lee GT, Kwon SJ, Lee JH, Jeon SS, Jang KT, Choi HY, Lee HM, Kim WJ, Lee DH, Kim IY. Macrophages induce neuroendocrine differentiation of prostate cancer cells via BMP6-IL6 Loop. Prostate. 2011;71(14):1525-37. PMID: 21374653. 

Lee GT, Kwon SJ, Lee JH, Jeon SS, Jang KT, Choi HY, Lee HM, Kim WJ, Kim SJ, Kim IY. Induction of interleukin-6 expression by bone morphogenetic protein-6 in macrophages requires both SMAD and p38 signaling pathways. J Biol Chem. 2010;285(50):39401-8. PMID: 20889504; PMCID: PMC2998138. 


Nagaya N, Nagata M, Lu Y, Kanayama M, Hou Q, Hotta ZU, China T, Kitamura K, Matsushita K, Isotani S, Muto S, Sakamoto Y, Horie S. Prostate-specific membrane antigen in circulating tumor cells is a new poor prognostic marker for castration-resistant prostate cancer. PLoS One. 2020 Jan 27;15(1):e0226219. doi: 10.1371/journal.pone.0226219. eCollection 2020. PMID:31986176

Nagaya N, Shimizu F, Kanayama M, Hotta ZU, Nozaki T, Wakumoto Y, Tujimura A, Horie S. Movement of target organs and anatomical landmarks caused by body position change during urological laparoscopic surgery. Asian J Endosc Surg. 2020 Jan;13(1):65-70. doi: 10.1111/ases.12699. Epub 2019 Mar 13. PMID:30868760

Nagaya N, Horie S. [Endocrine therapy for prostate cancer.] Clin Calcium. 2018;28(11):1527-1533. doi: CliCa181115271533. Review. Japanese. PMID:30374010

Nagaya N, Kanayama M, Nagata M, Horie S. The Surge in the Number of Circulating Tumor Cells Following Treatment with Sunitinib for Metastatic Renal Cell Carcinoma. Intern Med. 2018 Sep 15;57(18):2695-2700. doi: 10.2169/internalmedicine.0663-17. Epub 2018 Apr 27. PMID:29709937