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Researcher Publications

Yanxiang (Jessie) Guo, PhD

Selected Publications

  • Ghergurovich JM, Esposito M, Chen Z, Wang JZ, Bhatt V, Lan T, White E, Kang Y, Guo JY, Rabinowitz JD. Glucose-6-Phosphate Dehydrogenase Is Not Essential for K-Ras-Driven Tumor Growth or Metastasis. Cancer Res. 2020 Sep 15;80(18):3820-3829. doi: 10.1158/0008-5472.CAN-19-2486. Epub 2020 Jul 13. PubMed PMID: 32661137; PubMed Central PMCID: PMC7501231.
  • Feng WW, Wilkins O, Bang S, Ung M, Li J, An J, Del Genio C, Canfield K, DiRenzo J, Wells W, Gaur A, Robey RB, Guo JY, Powles RL, Sotiriou C, Pusztai L, Febbraio M, Cheng C, Kinlaw WB, Kurokawa M. CD36-Mediated Metabolic Rewiring of Breast Cancer Cells Promotes Resistance to HER2-Targeted Therapies. Cell Rep. 2019 Dec 10;29(11):3405-3420.e5. doi: 10.1016/j.celrep.2019.11.008. PubMed PMID: 31825825; PubMed Central PMCID: PMC6938262.
  • Bott AJ, Shen J, Tonelli C, Zhan L, Sivaram N, Jiang YP, Yu X, Bhatt V, Chiles E, Zhong H, Maimouni S, Dai W, Velasquez S, Pan JA, Muthalagu N, Morton J, Anthony TG, Feng H, Lamers WH, Murphy DJ, Guo JY, Jin J, Crawford HC, Zhang L, White E, Lin RZ, Su X, Tuveson DA, Zong WX.Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism. Cell Rep. 2019 Oct 29;29(5):1287-1298.e6. doi: 10.1016/j.celrep.2019.09.056. PubMed PMID: 31665640; PubMed Central PMCID: PMC6886125.
  • Liu J, Zhang Q, Ruan B, Chen W, Zheng J, Xu B, Jiang P, Miao Z, Li F, Guo JY, Cao L, Wang G. MORC2 regulates C/EBPα-mediated cell differentiation via sumoylation. Cell Death Differ. 2019 Oct;26(10):1905-1917. doi: 10.1038/s41418-018-0259-4. Epub 2019 Jan 15. PubMed PMID: 30644437; PubMed Central PMCID: PMC6748086.
  • Bhatt V, Khayati K, Hu ZS, Lee A, Kamran W, Su X, Guo JY. Autophagy modulates lipid metabolism to maintain metabolic flexibility for Lkb1-deficient Kras-driven lung tumorigenesis. Genes Dev. 2019 Feb 1;33(3-4):150-165. doi: 10.1101/gad.320481.118. Epub 2019 Jan 28. PubMed PMID: 30692209; PubMed Central PMCID: PMC6362813.
  • Poillet-Perez L, Xie X, Zhan L, Yang Y, Sharp DW, Hu ZS, Su X, Maganti A, Jiang C, Lu W, Zheng H, Bosenberg MW, Mehnert JM, Guo JY, Lattime E, Rabinowitz JD, White E. Autophagy maintains tumour growth through circulating arginine. Nature. 2018 Nov;563(7732):569-573. doi: 10.1038/s41586-018-0697-7. Epub 2018 Nov 14. PubMed PMID: 30429607; PubMed Central PMCID: PMC6287937.
  • Hui S, Ghergurovich JM, Morscher RJ, Jang C, Teng X, Lu W, Esparza LA, Reya T, Le Zhan, Yanxiang Guo J, White E, Rabinowitz JD. Glucose feeds the TCA cycle via circulating lactate. Nature. 2017 Nov 2;551(7678):115-118. doi: 10.1038/nature24057. Epub 2017 Oct 18. PubMed PMID: 29045397; PubMed Central PMCID: PMC5898814.
  • Qiu G, Liu J, Cheng Q, Wang Q, Jing Z, Pei Y, Zhao M, Wang J, Guo JY, Zhang J. Impaired Autophagy and Defective T Cell Homeostasis in Mice with T Cell-Specific Deletion of Receptor for Activated C Kinase 1. Front Immunol. 2017;8:575. doi: 10.3389/fimmu.2017.00575. eCollection 2017. PubMed PMID: 28572806; PubMed Central PMCID: PMC5435764.
  • Guo JY, White E. Autophagy, Metabolism, and Cancer. Cold Spring Harb Symp Quant Biol. 2016;81:73-78. doi: 10.1101/sqb.2016.81.030981. Epub 2017 Feb 16. Review. PubMed PMID: 28209717; PubMed Central PMCID: PMC5521269.
  • Lashinger LM, O'Flanagan CH, Dunlap SM, Rasmussen AJ, Sweeney S, Guo JY, Lodi A, Tiziani S, White E, Hursting SD. Starving cancer from the outside and inside: separate and combined effects of calorie restriction and autophagy inhibition on Ras-driven tumors. Cancer Metab. 2016;4:18. doi: 10.1186/s40170-016-0158-4. eCollection 2016. PubMed PMID: 27651895; PubMed Central PMCID: PMC5025535.
  • Guo JY, Teng X, Laddha SV, Ma S, Van Nostrand SC, Yang Y, Khor S, Chan CS, Rabinowitz JD, White E. Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells. Genes Dev. 2016 Aug 1;30(15):1704-17. doi: 10.1101/gad.283416.116. Epub 2016 Aug 11. PubMed PMID: 27516533; PubMed Central PMCID: PMC5002976.
  • Karsli-Uzunbas G, Guo JY, Price S, Teng X, Laddha SV, Khor S, Kalaany NY, Jacks T, Chan CS, Rabinowitz JD, White E. Autophagy is required for glucose homeostasis and lung tumor maintenance. Cancer Discov. 2014 Aug;4(8):914-27. doi: 10.1158/2159-8290.CD-14-0363. Epub 2014 May 29. PubMed PMID: 24875857; PubMed Central PMCID: PMC4125614.
  • Guo JY, Xia B, White E. Autophagy-mediated tumor promotion. Cell. 2013 Dec 5;155(6):1216-9. doi: 10.1016/j.cell.2013.11.019. Review. PubMed PMID: 24315093; PubMed Central PMCID: PMC3987898.
  • Strohecker AM, Guo JY, Karsli-Uzunbas G, Price SM, Chen GJ, Mathew R, McMahon M, White E. Autophagy sustains mitochondrial glutamine metabolism and growth of BrafV600E-driven lung tumors. Cancer Discov. 2013 Nov;3(11):1272-85. doi: 10.1158/2159-8290.CD-13-0397. Epub 2013 Aug 21. PubMed PMID: 23965987; PubMed Central PMCID: PMC3823822.
  • Guo JY, White E. Autophagy is required for mitochondrial function, lipid metabolism, growth, and fate of KRAS(G12D)-driven lung tumors.Autophagy. 2013 Oct;9(10):1636-8. doi: 10.4161/auto.26123. Epub 2013 Aug 15. Review. PubMed PMID: 23959381; PubMed Central PMCID: PMC5424446.
  • Guo JY, Karsli-Uzunbas G, Mathew R, Aisner SC, Kamphorst JJ, Strohecker AM, Chen G, Price S, Lu W, Teng X, Snyder E, Santanam U, Dipaola RS, Jacks T, Rabinowitz JD, White E. Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes Dev. 2013 Jul 1;27(13):1447-61. doi: 10.1101/gad.219642.113. PubMed PMID: 23824538; PubMed Central PMCID: PMC3713426.
  • Guo JY, Chen HY, Mathew R, Fan J, Strohecker AM, Karsli-Uzunbas G, Kamphorst JJ, Chen G, Lemons JM, Karantza V, Coller HA, Dipaola RS, Gelinas C, Rabinowitz JD, White E. Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev. 2011 Mar 1;25(5):460-70. doi: 10.1101/gad.2016311. Epub 2011 Feb 11. PubMed PMID: 21317241; PubMed Central PMCID: PMC3049287.
  • White E, Karp C, Strohecker AM, Guo Y, Mathew R. Role of autophagy in suppression of inflammation and cancer. Curr Opin Cell Biol. 2010 Apr;22(2):212-7. doi: 10.1016/j.ceb.2009.12.008. Epub 2010 Jan 6. Review. PubMed PMID: 20056400; PubMed Central PMCID: PMC2857707.

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