Genome Editing - Research Accomplishments

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In the 2018 – 2022 period, the GESR supported approximately 35 cancer-relevant publications, of which 8 were in high Impact Factor journals:


Tseng HC, Xiong W, Badeti S, Yang Y, Ma M, Liu T, Ramos CA, Dotti G, Fritzky L, Jiang JG, Yi Q, Guarrera J, Zong WX, Liu C, Liu D. Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma. Nat Commun. 2020;11(1):4810. doi: 10.1038/s41467-020-18444-2. PubMed PMID: 32968061; PMCID: PMC7511348.

D'Agostino L, Nie Y, Goswami S, Tong K, Yu S, Bandyopadhyay S, Flores J, Zhang X, Balasubramanian I, Joseph I, Sakamori R, Farrell V, Li Q, Yang CS, Gao B, Ferraris RP, Yehia G, Bonder EM, Goldenring JR, Verzi MP, Zhang L, Ip YT, Gao N. Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling. Cancer Res. 2019;79(16):4099-112. doi: 10.1158/0008-5472.CAN-18-4075. PubMed PMID: 31239271; PMCID: PMC6726494.

Wang Y, Liu B, Lu H, Liu J, Romanienko PJ, Montelione GT, Shen Z. SETD4-mediated KU70 methylation suppresses apoptosis. Cell Rep. 2022;39(6):110794. doi: 10.1016/j.celrep.2022.110794. PubMed PMID: 35545041; PMCID: PMC9201767.

Tottone L, Lancho O, Loh JW, Singh A, Kimura S, Roels J, Kuchmiy A, Strubbe S, Lawlor MA, da Silva-Diz V, Luo S, Gachet S, Garcia-Prieto CA, Hagelaar R, Esteller M, Meijerink JPP, Soulier J, Taghon T, Van Vlierberghe P, Mullighan CG, Khiabanian H, Rocha PP, Herranz D. A Tumor Suppressor Enhancer of PTEN in T-cell development and leukemia. Blood Cancer Discov. 2021;2(1):92-109. doi: 10.1158/2643-3230.BCD-20-0201. PubMed PMID: 33458694; PMCID: PMC7810363.

Stahley SN, Basta LP, Sharan R, Devenport D. Celsr1 adhesive interactions mediate the asymmetric organization of planar polarity complexes. Elife. 2021;10. doi: 10.7554/eLife.62097. PubMed PMID: 33529151; PMCID: PMC7857726.

Foo TK, Vincelli G, Huselid E, Her J, Zheng H, Simhadri S, Wang M, Huo Y, Li T, Yu X, Li H, Zhao W, Bunting SF, Xia B. ATR/ATM-Mediated Phosphorylation of BRCA1 T1394 Promotes Homologous Recombinational Repair and G(2)-M Checkpoint Maintenance. Cancer Res. 2021;81(18):4676-84. doi: 10.1158/0008-5472.CAN-20-2723. PubMed PMID: 34301763; PMCID: PMC8448966.

Yu S, Balasubramanian I, Laubitz D, Tong K, Bandyopadhyay S, Lin X, Flores J, Singh R, Liu Y, Macazana C, Zhao Y, Beguet-Crespel F, Patil K, Midura-Kiela MT, Wang D, Yap GS, Ferraris RP, Wei Z, Bonder EM, Haggblom MM, Zhang L, Douard V, Verzi MP, Cadwell K, Kiela PR, Gao N. Paneth Cell-Derived Lysozyme Defines the Composition of Mucolytic Microbiota and the Inflammatory Tone of the Intestine. Immunity. 2020;53(2):398-416 e8. doi: 10.1016/j.immuni.2020.07.010. PubMed PMID: 32814028; PMCID: PMC7461615.

Kwon M, Rubio G, Nolan N, Auteri P, Volmar JA, Adem A, Javidian P, Zhou Z, Verzi MP, Pine SR, Libutti SK. FILIP1L Loss Is a Driver of Aggressive Mucinous Colorectal Adenocarcinoma and Mediates Cytokinesis Defects through PFDN1. Cancer Res. 2021;81(21):5523-39. doi: 10.1158/0008-5472.CAN-21-0897. PubMed PMID: 34417201; PMCID: PMC8563430.