Program Leaders: Eileen White, PhD and Wei-Xing Zong, PhD
To determine how oncogenic signaling promotes tumor cell metabolism, growth, and survival, and alters tumor-host interaction to facilitate disease progression. The ultimate goal is to identify new targets for drug development to improve cancer therapy.
- To establish the role of cellular and mammalian metabolism in the control of tumor cell growth and survival and to modulate metabolic pathways to improve cancer therapy
- To define the basic mechanisms of cell growth, proliferation, survival, stress adaptation, and metastasis in tumor cells
- To identify the functional relationship between the tumor and host and how to harness host metabolism and immune response for anti-cancer therapy