Chan Laboratory - Select Publications

  1. Levine AJ, Chan CS, Dudgeon C, Puzio-Kuter A, Hainaut P. The Evolution of Tumors in Mice and Humans with Germline p53 Mutations. Cold Spring Harbor symposia on quantitative biology. 2015;  PMID: 26642854
  2. Joshi S, Tolkunov D, Aviv H, Hakimi AA, Yao M, et al. The Genomic Landscape of Renal Oncocytoma Identifies a Metabolic Barrier to Tumorigenesis. Cell reports. 2015; 13(9):1895-908.  PMID: 26655904
  3. White E, Mehnert JM, Chan CS. Autophagy, Metabolism, and Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2015; 21(22):5037-46. NIHMSID: NIHMS728175  PMID: 26567363, PMCID: PMC4646728
  4. Puzio-Kuter AM, Laddha SV, Castillo-Martin M, Sun Y, Cordon-Cardo C, et al. Involvement of tumor suppressors PTEN and p53 in the formation of multiple subtypes of liposarcoma. Cell death and differentiation. 2015; 22(11):1785-91. PMID: 25822339, PMCID: PMC4648325
  5. Dudgeon C, Chan C, Kang W, Sun Y, Emerson R, et al. The evolution of thymic lymphomas in p53 knockout mice. Genes & development. 2014; 28(23):2613-20. PubMed [journal] PMID: 25452272, PMCID: PMC4248292
  6. Ariffin H, Hainaut P, Puzio-Kuter A, Choong SS, Chan AS, et al. Whole-genome sequencing analysis of phenotypic heterogeneity and anticipation in Li-Fraumeni cancer predisposition syndrome. Proceedings of the National Academy of Sciences of the United States of America. 2014; 111(43):15497-501.  PMID: 25313051, PMCID: PMC4217424
  7. Zhang C, Liu J, Wang X, Wu R, Lin M, et al. MicroRNA-339-5p inhibits colorectal tumorigenesis through regulation of the MDM2/p53 signaling. Oncotarget. 2014; 5(19):9106-17.  PMID: 25193859, PMCID: PMC4253422
  8. Wong C, Laddha SV, Tang L, Vosburgh E, Levine AJ, et al. The bromodomain and extra-terminal inhibitor CPI203 enhances the antiproliferative effects of rapamycin on human neuroendocrine tumors. Cell death & disease. 2014; 5:e1450. PMID: 25299775, PMCID: PMC4237236
  9. Karsli-Uzunbas G, Guo JY, Price S, Teng X, Laddha SV, et al. Autophagy is required for glucose homeostasis and lung tumor maintenance. Cancer discovery. 2014; 4(8):914-27. NIHMSID: NIHMS600167  PMID: 24875857, PMCID: PMC4125614
  10. Zhang C, Liu J, Wu R, Liang Y, Lin M, et al. Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD. Oncotarget. 2014; 5(14):5535-46.  PMID: 25114038, PMCID: PMC4170611
  11. Laddha SV, Ganesan S, Chan CS, White E. Mutational landscape of the essential autophagy gene BECN1 in human cancers. Molecular cancer research : MCR. 2014; 12(4):485-90. NIHMSID: NIHMS560860  PMID: 24478461, PMCID: PMC3989371
  12. Sagne C, Marcel V, Bota M, Martel-Planche G, Nobrega A, et al. Age at cancer onset in germline TP53 mutation carriers: association with polymorphisms in predicted G-quadruplex structures. Carcinogenesis. 2014; 35(4):807-15. PubMed [journal] PMID: 24336192, PMCID: PMC3977145
  13. Hu W, Chan CS, Wu R, Zhang C, Sun Y, et al. Negative regulation of tumor suppressor p53 by microRNA miR-504. Molecular cell. 2010; 38(5):689-99. NIHMSID: NIHMS211731 PMID: 20542001, PMCID: PMC2900922
  14. Chan CS, Song JS. CCCTC-binding factor confines the distal action of estrogen receptor. Cancer research. 2008; 68(21):9041-9.  PMID: 18974150
  15. Chan CS, Elemento O, Tavazoie S. Revealing posttranscriptional regulatory elements through network-level conservation. PLoS computational biology. 2005; 1(7):e69. PMID: 16355253, PMCID: PMC1309705

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