Metabolomics

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Director: Joshua Rabinowitz, MD, PhD

Co-Director: Xiaoyang Su, PhD

The past decade has seen a surge of interest in tumor metabolism, driven by the recognition that oncogenes up-regulate metabolism and that certain metabolites can themselves cause cancer (“oncometabolites”). In 2011 the consortium Cancer Center established a shared resource for Metabolomics, with both the Princeton and New Brunswick sites. This shared resource pushes the frontiers of tumor metabolism measurement and provides Rutgers Cancer Institute members with easy, cost-effective access to these capabilities. The overarching objective is to enable scientific discoveries that significantly impact cancer diagnosis and therapy.

The specific objectives of the Metabolomics shared resource are:

  • Provide access to basic metabolism measurement capabilities, such as oxygen uptake by Seahorse analyzer
  • Provide more advanced services, such as large-scale quantitative metabolite measurement by LC-MS
  • Develop and collaboratively apply cutting-edge metabolism measurement capabilities including isotope tracing
  • Engage users at all stages of the metabolomics research process, guiding experimental design, conducting analyses, and assisting users with data analysis.
  • Enhance scientific interaction and productivity across the consortium
  • Accelerates research programs towards new diagnostic or therapeutic approaches for cancer
  • Provide cost-effective pricing and expeditious turnaround times

ACKNOWLEDGEMENT OF METABOLOMICS SHARED RESOURCES

The Metabolomics shared resource of Rutgers Cancer Institute of New Jersey is a specialized service facility that supports the cancer research efforts of our members.

This facility is supported primarily by the Cancer Center Support Grant (CCSG) from the National Cancer Institute.  Additional support may be provided from other sources, such as chargeback systems, institutional funding and/or other grants. The support from the CCSG allows the facility to provide benefits to Cancer Center members, such as ensured access to services or subsidies to user rates.

Please remember to acknowledge the valuable services provided by the Metabolomics shared resource in your research papers, publications, and grant applications. The following acknowledgment statement is recommended:

"This research was supported by the Metabolomics shared resource of Rutgers Cancer Institute of New Jersey (P30CA072720)."

(Note: please also consider including the names of individuals from the shared resource if they provided any intellectual input or additional effort.)

 

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