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Yufang Shi, DVM, MSc,PhD

Publications since 2011

Wang, Y. Chen, X. Cao, W. Shi, Y. Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications. Nat Immunol, 15:1009-1016, . (PMID: 25329189)

Ren, G. Liu, Y. Zhao, X. Zhang, J. Zheng, B. Yuan, Z. R. Zhang, L. Qu, X. Tischfield, J. A. Shao, C. Shi, Y. Tumor resident mesenchymal stromal cells endow naive stromal cells with tumor-promoting properties. Oncogene, 33:4016-4020, . (PMID: 24077286)

Han, X. Yang, Q. Lin, L. Xu, C. Zheng, C. Chen, X. Han, Y. Li, M. Cao, W. Cao, K. Chen, Q. Xu, G. Zhang, Y. Zhang, J. Schneider, R. J. Qian, Y. Wang, Y. Brewer, G. Shi, Y. Interleukin-17 enhances immunosuppression by mesenchymal stem cells. Cell Death Differ, In process, . (PMID: 25034782)

Huang, Y. Yu, P. Li, W. Ren, G. Roberts, A. I. Cao, W. Zhang, X. Su, J. Chen, X. Chen, Q. Shou, P. Xu, C. Du, L. Lin, L. Xie, N. Zhang, L. Wang, Y. Shi, Y. p53 regulates mesenchymal stem cell-mediated tumor suppression in a tumor microenvironment through immune modulation. Oncogene, 33:3830-3838, . (PMID: 23975435)

Cao, G. Yang, Q. Zhang, S. Xu, C. Roberts, A. I. Wang, Y. Shi, Y. Mesenchymal Stem Cells Prevent Restraint Stress-Induced Lymphocyte Depletion via Interleukin-4. Brain Behav Immun, 38:125-132, . (PMID: 24480719)

Su, J. Chen, X. Huang, Y. Li, W. Li, J. Cao, K. Cao, G. Zhang, L. Li, F. Roberts, A. I. Kang, H. Yu, P. Ren, G. Ji, W. Wang, Y. Shi, Y. Phylogenetic distinction of iNOS and IDO function in mesenchymal stem cell-mediated immunosuppression in mammalian species. Cell Death Differ, 21:388-396, . (PMID: 24162664, PMCID: PMC3921585)

Ling, W. Zhang, J. Yuan, Z. Ren, G. Zhang, L. Chen, X. Rabson, A. B. Roberts, A. I. Wang, Y. Shi, Y. Mesenchymal Stem Cells Employ IDO to Regulate Immunity in Tumor Microenvironment. Cancer Res, 74:1576-1587, . (PMID: 24452999, PMCID: PMC3959857)

Chen, Q. Shou, P. Zhang, L. Xu, C. Zheng, C. Han, Y. Li, W. Huang, Y. Zhang, X. Shao, C. Roberts, A. I. Rabson, A. B. Ren, G. Zhang, Y. Wang, Y. Denhardt, D. T. Shi, Y. An Osteopontin-Integrin interaction plays a critical role in directing adipogenesis and osteogenesis by mesenchymal stem cells. Stem Cells, 32:327-337, . (PMID: 24123709, PMCID: PMC3961005)

Ma, S. Xie, N. Li, W. Yuan, B. Shi, Y. Wang, Y. Immunobiology of mesenchymal stem cells. Cell Death Differ, 21:216-225, . (PMID: 24185619, PMCID: PMC3890955)

Chen, X. Gan, Y. Li, W. Su, J. Zhang, Y. Huang, Y. Roberts, A. I. Han, Y. Li, J. Wang, Y. Shi, Y. The interaction between mesenchymal stem cells and steroids during inflammation. Cell Death Dis, 5:e1009, . (PMID: 24457953, PMCID: PMC4040685)

Zhang, J. Roberts, A. I. Liu, C. Ren, G. Xu, G. Zhang, L. Devadas, S. Shi, Y. A novel subset of helper T cells promotes immune responses by secreting GM-CSF. Cell Death Differ, 20:1731-1741, . (PMID: 24076588, PMCID: PMC3824596)

Zeng, A. Li, Y. Q. Wang, C. Han, X. S. Li, G. Wang, J. Y. Li, D. S. Qin, Y. W. Shi, Y. Brewer, G. Jing, Q. Heterochromatin protein 1 promotes self-renewal and triggers regenerative proliferation in adult stem cells. J Cell Biol, 201:409-425, . (PMID: 23629965, PMCID: PMC3639387)

Xu, C. Ren, G. Cao, G. Chen, Q. Shou, P. Zheng, C. Du, L. Han, X. Jiang, M. Yang, Q. Lin, L. Wang, G. Yu, P. Zhang, X. Cao, W. Brewer, G. Wang, Y. Shi, Y. miR-155 regulates immune modulatory properties of mesenchymal stem cells by targeting TAK1-binding protein 2. J Biol Chem, 288:11074-11079, . (PMID: 23449975, PMCID: PMC3630877)

Wu, X. Chesoni, S. Rondeau, G. Tempesta, C. Patel, R. Charles, S. Daginawala, N. Zucconi, B. E. Kishor, A. Xu, G. Shi, Y. Li, M. L. Irizarry-Barreto, P. Welsh, J. Wilson, G. M. Brewer, G. Combinatorial mRNA binding by AUF1 and Argonaute 2 controls decay of selected target mRNAs. Nucleic Acids Res, 41:2644-2658, . (PMID: 23303783, PMCID: PMC3575833)

Ren, G. Zhao, X. Wang, Y. Zhang, X. Chen, X. Xu, C. Yuan, Z. R. Roberts, A. I. Zhang, L. Zheng, B. Wen, T. Han, Y. Rabson, A. B. Tischfield, J. A. Shao, C. Shi, Y. CCR2-Dependent Recruitment of Macrophages by Tumor-Educated Mesenchymal Stromal Cells Promotes Tumor Development and Is Mimicked by TNFalpha Cell Stem Cell, 11:812-824, . (PMID: 23168163, PMCID: PMC3518598)

Qu, F. Gao, H. Zhu, S. Shi, P. Zhang, Y. Liu, Y. Jallal, B. Yao, Y. Shi, Y. Qian, Y. TRAF6-dependent Act1 phosphorylation by the IkappaB kinase-related kinases suppresses interleukin-17-induced NF-kappaB activation. Mol Cell Biol, 32:3925-3937, . (PMID: 22851696, PMCID: PMC3457531)

Li, W. Ren, G. Huang, Y. Su, J. Han, Y. Li, J. Chen, X. Cao, K. Chen, Q. Shou, P. Zhang, L. Yuan, Z. R. Roberts, A. I. Shi, S. Le, A. D. Shi, Y. Mesenchymal stem cells: a double-edged sword in regulating immune responses. Cell Death Differ, 19:1505-1513, . (PMID: 22421969, PMCID: PMC3422473)

Zhu, S. Pan, W. Song, X. Liu, Y. Shao, X. Tang, Y. Liang, D. He, D. Wang, H. Liu, W. Shi, Y. Harley, J. B. Shen, N. Qian, Y. The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-alpha. Nat Med, 18:1077-1086, . (PMID: 22660635)

Yao, Y. Wang, Y. Chen, F. Huang, Y. Zhu, S. Leng, Q. Wang, H. Shi, Y. Qian, Y. NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens. Cell Res, 22:836-847, . (PMID: 22491475, PMCID: PMC3346158)

Shi, Y. Su, J. Roberts, A. I. Shou, P. Rabson, A. B. Ren, G. How mesenchymal stem cells interact with tissue immune responses. Trends Immunol, 33:136-143, . (PMID: 22227317, PMCID: PMC3412175)

Shi, Y. Wei, L. Wang, Y. Ren, G. Stem cells deployed for bone repair hijacked by T cells. Cell Stem Cell, 10:6-8, . (PMID: 22226348)

Sensebe, L. Tarte, K. Galipeau, J. Krampera, M. Martin, I. Phinney, D. G. Shi, Y. Limited acquisition of chromosomal aberrations in human adult mesenchymal stromal cells. Cell Stem Cell, 10:9-10; author reply 10, . (PMID: 22226349)

Han, Z. Jing, Y. Zhang, S. Liu, Y. Shi, Y. Wei, L. The role of immunosuppression of mesenchymal stem cells in tissue repair and tumor growth. Cell Biosci, 2:8, . (PMID: 22390479, PMCID: PMC3315743)

Song, X. Zhu, S. Shi, P. Liu, Y. Shi, Y. Levin, S. D. Qian, Y. IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens. Nat Immunol, 12:1151-1158, . (PMID: 21993849)

Han, Z. Tian, Z. Lv, G. Zhang, L. Jiang, G. Sun, K. Wang, C. Bu, X. Li, R. Shi, Y. Wu, M. Wei, L. Immunosuppressive effect of bone marrow-derived mesenchymal stem cells in inflammatory microenvironment favours the growth of B16 melanoma cells. J Cell Mol Med, 15:2343-2352, . (PMID: 21091630)

Cao, W. Yang, Y. Wang, Z. Liu, A. Fang, L. Wu, F. Hong, J. Shi, Y. Leung, S. Dong, C. Zhang, J. Z. Leukemia inhibitory factor inhibits T helper 17 cell differentiation and confers treatment effects of neural progenitor cell therapy in autoimmune disease. Immunity, 35:273-284, . (PMID: 21835648)

Krause, C. D. Izotova, L. S. Ren, G. Yuan, Z. R. Shi, Y. Chen, C. C. Ron, Y. Pestka, S. Efficient co-expression of bicistronic proteins in mesenchymal stem cells by development and optimization of a multifunctional plasmid. Stem Cell Res Ther, In process, . (PMID: 21401924)

Zhao, F. Zhang, Y. Wang, H. Jin, M. He, S. Shi, Y. Guo, Y. Zhang, Y. Blockade of osteopontin reduces alloreactive CD8+ T cell-mediated graft-versus-host disease. Blood, 117:1723-1733, . (PMID: 21119110, PMCID: PMC3056597)

Ren, G. Roberts, A. I. Shi, Y. Adhesion molecules: key players in Mesenchymal stem cell-mediated immunosuppression. Cell Adh Migr, 5:20-22, . (PMID: 20935502, PMCID: PMC3038091)

Shi, P. Zhu, S. Lin, Y. Liu, Y. Liu, Y. Chen, Z. Shi, Y. Qian, Y. Persistent stimulation with interleukin-17 desensitizes cells through SCFbeta-TrCP-mediated degradation of Act1. Sci Signal, 4:ra73, . (PMID: 22045853)