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Yufang Shi, DVM, MSc,PhD

Publications since 2011

Han, X. Yang, Q. Lin, L. Xu, C. Zheng, C. Chen, X. Han, Y. Li, M. Cao, W. Cao, K. Chen, Q. Xu, G. Zhang, Y. Zhang, J. Schneider, R. J. Qian, Y. Wang, Y. Brewer, G. Shi, Y. Interleukin-17 enhances immunosuppression by mesenchymal stem cells. Cell Death Differ, 21:1758-1768, . (PMID: 25034782, PMCID: PMC4211372)

Wang, Y. Chen, X. Cao, W. Shi, Y. Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications. Nat Immunol, 15:1009-1016, . (PMID: 25329189)

Xu, C. Lin, L. Cao, G. Chen, Q. Shou, P. Huang, Y. Han, Y. Wang, Y. Shi, Y. Interferon-alpha-secreting mesenchymal stem cells exert potent antitumor effect in vivo. Oncogene, 33:5047-5052, . (PMID: 24186200)

Ke, F. Zhang, L. Liu, Z. Liu, J. Yan, S. Xu, Z. Bai, J. Zhu, H. Lou, F. Wang, H. Shi, Y. Jiang, Y. Su, B. Wang, H. Autocrine interleukin-6 drives skin-derived mesenchymal stem cell trafficking via regulating voltage-gated Ca(2+) channels. Stem Cells, 32:2799-2810, . (PMID: 24906203)

Liu, S. Sun, X. Wang, M. Hou, Y. Zhan, Y. Jiang, Y. Liu, Z. Cao, X. Chen, P. Liu, Z. Chen, X. Tao, Y. Xu, C. Mao, J. Cheng, C. Li, C. Hu, Y. Wang, L. Chin, Y. E. Shi, Y. Siebenlist, U. Zhang, X. A microRNA 221- and 222-mediated feedback loop maintains constitutive activation of NFkappaB and STAT3 in colorectal cancer cells. Gastroenterology, 147:847-859.e11, . (PMID: 24931456)

Zhu, K. Zhang, N. Guo, N. Yang, J. Wang, J. Yang, C. Yang, C. Zhu, L. Xu, C. Deng, Q. Zhu, R. Wang, H. Chen, X. Shi, Y. Li, Y. Leng, Q. SSC(high)CD11b(high)Ly-6C(high)Ly-6G(low) myeloid cells curtail CD4 T cell response by inducible nitric oxide synthase in murine hepatitis. Int J Biochem Cell Biol, 54:89-97, . (PMID: 25035167)

Ren, G. Liu, Y. Zhao, X. Zhang, J. Zheng, B. Yuan, Z. R. Zhang, L. Qu, X. Tischfield, J. A. Shao, C. Shi, Y. Tumor resident mesenchymal stromal cells endow naive stromal cells with tumor-promoting properties. Oncogene, 33:4016-4020, . (PMID: 24077286)

Huang, Y. Yu, P. Li, W. Ren, G. Roberts, A. I. Cao, W. Zhang, X. Su, J. Chen, X. Chen, Q. Shou, P. Xu, C. Du, L. Lin, L. Xie, N. Zhang, L. Wang, Y. Shi, Y. p53 regulates mesenchymal stem cell-mediated tumor suppression in a tumor microenvironment through immune modulation. Oncogene, 33:3830-3838, . (PMID: 23975435)

Cao, G. Yang, Q. Zhang, S. Xu, C. Roberts, A. I. Wang, Y. Shi, Y. Mesenchymal Stem Cells Prevent Restraint Stress-Induced Lymphocyte Depletion via Interleukin-4. Brain Behav Immun, 38:125-132, . (PMID: 24480719)

Su, J. Chen, X. Huang, Y. Li, W. Li, J. Cao, K. Cao, G. Zhang, L. Li, F. Roberts, A. I. Kang, H. Yu, P. Ren, G. Ji, W. Wang, Y. Shi, Y. Phylogenetic distinction of iNOS and IDO function in mesenchymal stem cell-mediated immunosuppression in mammalian species. Cell Death Differ, 21:388-396, . (PMID: 24162664, PMCID: PMC3921585)

Ling, W. Zhang, J. Yuan, Z. Ren, G. Zhang, L. Chen, X. Rabson, A. B. Roberts, A. I. Wang, Y. Shi, Y. Mesenchymal Stem Cells Employ IDO to Regulate Immunity in Tumor Microenvironment. Cancer Res, 74:1576-1587, . (PMID: 24452999, PMCID: PMC3959857)

Chen, Q. Shou, P. Zhang, L. Xu, C. Zheng, C. Han, Y. Li, W. Huang, Y. Zhang, X. Shao, C. Roberts, A. I. Rabson, A. B. Ren, G. Zhang, Y. Wang, Y. Denhardt, D. T. Shi, Y. An Osteopontin-Integrin interaction plays a critical role in directing adipogenesis and osteogenesis by mesenchymal stem cells. Stem Cells, 32:327-337, . (PMID: 24123709, PMCID: PMC3961005)

Ma, S. Xie, N. Li, W. Yuan, B. Shi, Y. Wang, Y. Immunobiology of mesenchymal stem cells. Cell Death Differ, 21:216-225, . (PMID: 24185619, PMCID: PMC3890955)

Zhang, Y. Cai, W. Huang, Q. Gu, Y. Shi, Y. Huang, J. Zhao, F. Liu, Q. Wei, X. Jin, M. Wu, C. Xie, Q. Zhang, Y. Wan, B. Zhang, Y. Mesenchymal stem cells alleviate bacteria-induced liver injury in mice by inducing regulatory dendritic cells. Hepatology, 59:671-682, . (PMID: 23929707)

Song, X. Gao, H. Lin, Y. Yao, Y. Zhu, S. Wang, J. Liu, Y. Yao, X. Meng, G. Shen, N. Shi, Y. Iwakura, Y. Qian, Y. Alterations in the microbiota drive interleukin-17C production from intestinal epithelial cells to promote tumorigenesis. Immunity, 40:140-152, . (PMID: 24412611)

Chen, X. Gan, Y. Li, W. Su, J. Zhang, Y. Huang, Y. Roberts, A. I. Han, Y. Li, J. Wang, Y. Shi, Y. The interaction between mesenchymal stem cells and steroids during inflammation. Cell Death Dis, 5:e1009, . (PMID: 24457953, PMCID: PMC4040685)

Xu, C. Yu, P. Han, X. Du, L. Gan, J. Wang, Y. Shi, Y. TGF-beta promotes immune responses in the presence of mesenchymal stem cells. J Immunol, 192:103-109, . (PMID: 24293629)

Yang, X. Han, Z. P. Zhang, S. S. Zhu, P. X. Hao, C. Fan, T. T. Yang, Y. Li, L. Shi, Y. F. Wei, L. X. Chronic restraint stress decreases the repair potential from mesenchymal stem cells on liver injury by inhibiting TGF-beta1 generation. Cell Death Dis, 5:e1308, . (PMID: 24967970)

Zhang, M. Zhou, H. Zheng, C. Xiao, J. Zuo, E. Liu, W. Xie, D. Shi, Y. Wu, C. Wang, H. Li, D. Li, J. The roles of testicular c-kit positive cells in de novo morphogenesis of testis. Sci Rep, 4:5936, . (PMID: 25088917, PMCID: PMC4119999)

Yin, S. Yang, J. Lin, B. Deng, W. Zhang, Y. Yi, X. Shi, Y. Tao, Y. Cai, J. Wu, C. I. Zhao, G. Hurst, L. D. Zhang, J. Hu, L. Kong, X. Exome sequencing identifies frequent mutation of MLL2 in non-small cell lung carcinoma from Chinese patients. Sci Rep, 4:6036, . (PMID: 25112956)

Shi, Y. The 1000th publication features protection of normal cells during chemotherapy: a land mark for Cell Death & Disease. Cell Death Dis, 5:e1062, . (PMID: 24525738, PMCID: PMC3944265)

Wu, Q. Wang, H. Zhao, X. Shi, Y. Jin, M. Wan, B. Xu, H. Cheng, Y. Ge, H. Zhang, Y. Identification of G-protein-coupled receptor 120 as a tumor-promoting receptor that induces angiogenesis and migration in human colorectal carcinoma. Oncogene, 32:5541-5550, . (PMID: 23851494)

Zhang, J. Roberts, A. I. Liu, C. Ren, G. Xu, G. Zhang, L. Devadas, S. Shi, Y. A novel subset of helper T cells promotes immune responses by secreting GM-CSF. Cell Death Differ, 20:1731-1741, . (PMID: 24076588, PMCID: PMC3824596)

Yu, B. He, Z. Y. You, P. Han, Q. W. Xiang, D. Chen, F. Wang, M. J. Liu, C. C. Lin, X. W. Borjigin, U. Zi, X. Y. Li, J. X. Zhu, H. Y. Li, W. L. Han, C. S. Wangensteen, K. J. Shi, Y. Hui, L. J. Wang, X. Hu, Y. P. Reprogramming fibroblasts into bipotential hepatic stem cells by defined factors. Cell Stem Cell, 13:328-340, . (PMID: 23871605)

Krampera, M. Galipeau, J. Shi, Y. Tarte, K. Sensebe, L. Immunological characterization of multipotent mesenchymal stromal cells--The International Society for Cellular Therapy (ISCT) working proposal. Cytotherapy, 15:1054-1061, . (PMID: 23602578)

Liu, Z. Jiang, Y. Hou, Y. Hu, Y. Cao, X. Tao, Y. Xu, C. Liu, S. Wang, S. Wang, L. Shi, Y. Siebenlist, U. Zhang, X. The IkappaB family member Bcl-3 stabilizes c-Myc in colorectal cancer. J Mol Cell Biol, 5:280-282, . (PMID: 23794716)

Phinney, D. G. Galipeau, J. Krampera, M. Martin, I. Shi, Y. Sensebe, L. MSCs: science and trials. Nat Med, 19:812, . (PMID: 23836216)

Wei, X. Yang, X. Han, Z. P. Qu, F. F. Shao, L. Shi, Y. F. Mesenchymal stem cells: a new trend for cell therapy. Acta Pharmacol Sin, 34:747-754, . (PMID: 23736003, PMCID: PMC4002895)

Lang, J. Y. Shi, Y. Chin, Y. E. Reprogramming cancer cells: back to the future. Oncogene, 32:2247-2248, . (PMID: 22869153)

Zeng, A. Li, Y. Q. Wang, C. Han, X. S. Li, G. Wang, J. Y. Li, D. S. Qin, Y. W. Shi, Y. Brewer, G. Jing, Q. Heterochromatin protein 1 promotes self-renewal and triggers regenerative proliferation in adult stem cells. J Cell Biol, 201:409-425, . (PMID: 23629965, PMCID: PMC3639387)

Xu, C. Ren, G. Cao, G. Chen, Q. Shou, P. Zheng, C. Du, L. Han, X. Jiang, M. Yang, Q. Lin, L. Wang, G. Yu, P. Zhang, X. Cao, W. Brewer, G. Wang, Y. Shi, Y. miR-155 regulates immune modulatory properties of mesenchymal stem cells by targeting TAK1-binding protein 2. J Biol Chem, 288:11074-11079, . (PMID: 23449975, PMCID: PMC3630877)

Wu, X. Chesoni, S. Rondeau, G. Tempesta, C. Patel, R. Charles, S. Daginawala, N. Zucconi, B. E. Kishor, A. Xu, G. Shi, Y. Li, M. L. Irizarry-Barreto, P. Welsh, J. Wilson, G. M. Brewer, G. Combinatorial mRNA binding by AUF1 and Argonaute 2 controls decay of selected target mRNAs. Nucleic Acids Res, 41:2644-2658, . (PMID: 23303783, PMCID: PMC3575833)

Yang, X. Hou, J. Han, Z. Wang, Y. Hao, C. Wei, L. Shi, Y. One cell, multiple roles: contribution of mesenchymal stem cells to tumor development in tumor microenvironment. Cell Biosci, 3:5, . (PMID: 23336752, PMCID: PMC3693909)

Chen, P. Zhang, J. Zhan, Y. Su, J. Du, Y. Xu, G. Shi, Y. Siebenlist, U. Zhang, X. Correction: Established Thymic Epithelial Progenitor/Stem Cell-Like Cell Lines Differentiate into Mature Thymic Epithelial Cells and Support T Cell Development. PLoS One, 8:, . (PMID: 24244256, PMCID: PMC3824001)

Chen, P. Zhang, J. Zhan, Y. Su, J. Du, Y. Xu, G. Shi, Y. Siebenlist, U. Zhang, X. Established thymic epithelial progenitor/stem cell-like cell lines differentiate into mature thymic epithelial cells and support T cell development. PLoS One, 8:e75222, . (PMID: 24086471, PMCID: PMC3781041)

Liu, B. Chen, X. Wang, Y. Shi, Y. Curative effect of hepatic portal venous administration of autologous bone marrow in AIDS patients with decompensated liver cirrhosis. Cell Death Dis, 4:e739, . (PMID: 23887630, PMCID: PMC3730431)

Hou, J. Han, Z. P. Jing, Y. Y. Yang, X. Zhang, S. S. Sun, K. Hao, C. Meng, Y. Yu, F. H. Liu, X. Q. Shi, Y. F. Wu, M. C. Zhang, L. Wei, L. X. Autophagy prevents irradiation injury and maintains stemness through decreasing ROS generation in mesenchymal stem cells. Cell Death Dis, 4:e844, . (PMID: 24113178, PMCID: PMC3824648)

Ren, G. Zhao, X. Wang, Y. Zhang, X. Chen, X. Xu, C. Yuan, Z. R. Roberts, A. I. Zhang, L. Zheng, B. Wen, T. Han, Y. Rabson, A. B. Tischfield, J. A. Shao, C. Shi, Y. CCR2-Dependent Recruitment of Macrophages by Tumor-Educated Mesenchymal Stromal Cells Promotes Tumor Development and Is Mimicked by TNFalpha Cell Stem Cell, 11:812-824, . (PMID: 23168163, PMCID: PMC3518598)

Qu, F. Gao, H. Zhu, S. Shi, P. Zhang, Y. Liu, Y. Jallal, B. Yao, Y. Shi, Y. Qian, Y. TRAF6-dependent Act1 phosphorylation by the IkappaB kinase-related kinases suppresses interleukin-17-induced NF-kappaB activation. Mol Cell Biol, 32:3925-3937, . (PMID: 22851696, PMCID: PMC3457531)

Li, W. Ren, G. Huang, Y. Su, J. Han, Y. Li, J. Chen, X. Cao, K. Chen, Q. Shou, P. Zhang, L. Yuan, Z. R. Roberts, A. I. Shi, S. Le, A. D. Shi, Y. Mesenchymal stem cells: a double-edged sword in regulating immune responses. Cell Death Differ, 19:1505-1513, . (PMID: 22421969, PMCID: PMC3422473)

L'Huillier, A. Ren, G. Shi, Y. Zhang, J. A two-hit model of autoimmunity: lymphopenia and unresponsiveness to TGF-beta signaling. Cell Mol Immunol, 9:369-370, . (PMID: 22885528, PMCID: PMC4002331)

Zhu, S. Pan, W. Song, X. Liu, Y. Shao, X. Tang, Y. Liang, D. He, D. Wang, H. Liu, W. Shi, Y. Harley, J. B. Shen, N. Qian, Y. The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-alpha. Nat Med, 18:1077-1086, . (PMID: 22660635)

Yao, Y. Wang, Y. Chen, F. Huang, Y. Zhu, S. Leng, Q. Wang, H. Shi, Y. Qian, Y. NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens. Cell Res, 22:836-847, . (PMID: 22491475, PMCID: PMC3346158)

Shi, Y. Su, J. Roberts, A. I. Shou, P. Rabson, A. B. Ren, G. How mesenchymal stem cells interact with tissue immune responses. Trends Immunol, 33:136-143, . (PMID: 22227317, PMCID: PMC3412175)

Shi, Y. Wei, L. Wang, Y. Ren, G. Stem cells deployed for bone repair hijacked by T cells. Cell Stem Cell, 10:6-8, . (PMID: 22226348)

Sensebe, L. Tarte, K. Galipeau, J. Krampera, M. Martin, I. Phinney, D. G. Shi, Y. Limited acquisition of chromosomal aberrations in human adult mesenchymal stromal cells. Cell Stem Cell, 10:9-10; author reply 10, . (PMID: 22226349)

Han, Z. Jing, Y. Zhang, S. Liu, Y. Shi, Y. Wei, L. The role of immunosuppression of mesenchymal stem cells in tissue repair and tumor growth. Cell Biosci, 2:8, . (PMID: 22390479, PMCID: PMC3315743)

Ren, G. Chen, X. Dong, F. Li, W. Ren, X. Zhang, Y. Shi, Y. Concise review: mesenchymal stem cells and translational medicine: emerging issues. Stem Cells Transl Med, 1:51-58, . (PMID: 23197640, PMCID: PMC3727691)

Galluzzi, L. Vitale, I. Abrams, J. M. Alnemri, E. S. Baehrecke, E. H. Blagosklonny, M. V. Dawson, T. M. Dawson, V. L. El-Deiry, W. S. Fulda, S. Gottlieb, E. Green, D. R. Hengartner, M. O. Kepp, O. Knight, R. A. Kumar, S. Lipton, S. A. Lu, X. Madeo, F. Malorni, W. Mehlen, P. Nunez, G. Peter, M. E. Piacentini, M. Rubinsztein, D. C. Shi, Y. Simon, H. U. Vandenabeele, P. White, E. Yuan, J. Zhivotovsky, B. Melino, G. Kroemer, G. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ, 19:107-120, . (PMID: 21760595, PMCID: PMC3252826)

Song, X. Zhu, S. Shi, P. Liu, Y. Shi, Y. Levin, S. D. Qian, Y. IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens. Nat Immunol, 12:1151-1158, . (PMID: 21993849)

Han, Z. Tian, Z. Lv, G. Zhang, L. Jiang, G. Sun, K. Wang, C. Bu, X. Li, R. Shi, Y. Wu, M. Wei, L. Immunosuppressive effect of bone marrow-derived mesenchymal stem cells in inflammatory microenvironment favours the growth of B16 melanoma cells. J Cell Mol Med, 15:2343-2352, . (PMID: 21091630)

Cao, W. Yang, Y. Wang, Z. Liu, A. Fang, L. Wu, F. Hong, J. Shi, Y. Leung, S. Dong, C. Zhang, J. Z. Leukemia inhibitory factor inhibits T helper 17 cell differentiation and confers treatment effects of neural progenitor cell therapy in autoimmune disease. Immunity, 35:273-284, . (PMID: 21835648)

Krause, C. D. Izotova, L. S. Ren, G. Yuan, Z. R. Shi, Y. Chen, C. C. Ron, Y. Pestka, S. Efficient co-expression of bicistronic proteins in mesenchymal stem cells by development and optimization of a multifunctional plasmid. Stem Cell Res Ther, In process, . (PMID: 21401924)

Yamaza, T. Ren, G. Akiyama, K. Chen, C. Shi, Y. Shi, S. Mouse mandible contains distinctive mesenchymal stem cells. J Dent Res, 90:317-324, . (PMID: 21076121, PMCID: PMC3034836)

Zhao, F. Zhang, Y. Wang, H. Jin, M. He, S. Shi, Y. Guo, Y. Zhang, Y. Blockade of osteopontin reduces alloreactive CD8+ T cell-mediated graft-versus-host disease. Blood, 117:1723-1733, . (PMID: 21119110, PMCID: PMC3056597)

Ren, G. Roberts, A. I. Shi, Y. Adhesion molecules: key players in Mesenchymal stem cell-mediated immunosuppression. Cell Adh Migr, 5:20-22, . (PMID: 20935502, PMCID: PMC3038091)

Hu, G. Ren, G. Shi, Y. The putative cannabinoid receptor GPR55 promotes cancer cell proliferation. Oncogene, 30:139-141, . (PMID: 21057532)

Shi, P. Zhu, S. Lin, Y. Liu, Y. Liu, Y. Chen, Z. Shi, Y. Qian, Y. Persistent stimulation with interleukin-17 desensitizes cells through SCFbeta-TrCP-mediated degradation of Act1. Sci Signal, 4:ra73, . (PMID: 22045853)