Researcher Profiles

Return to member profile

Chung S. Yang, PhD

Publications since 2011

Chen, J. X. Liu, A. Lee, M. J. Wang, H. Yu, S. Chi, E. Reuhl, K. Suh, N. Yang, C. S. delta- and gamma-tocopherols inhibit phIP/DSS-induced colon carcinogenesis by protection against early cellular and DNA damages. Mol Carcinog, In process, . (PMID: 27175800)

Wang, H. Liu, A. Kuo, Y. Chi, E. Yang, X. Zhang, L. Yang, C. S. Obesity promotes PhIP-induced small intestinal carcinogenesis in hCYP1A-db/db mice: involvement of mutations and DNA hypermethylation of Apc. Carcinogenesis, In process, . (PMID: 27207656)

Zhu, L. Cheng, X. Shi, J. Lin, J. Chen, G. Jin, H. Liu, A. B. Pyo, H. Ye, J. Zhu, Y. Wang, H. Chen, H. Fang, J. Cai, L. Wang, T. C. Yang, C. S. Tu, S. P. Crosstalk between bone marrow-derived myofibroblasts and gastric cancer cells regulates cancer stemness and promotes tumorigenesis. Oncogene, In process, . (PMID: 27109105)

Yang, W. Zhang, Q. Yang, Y. Xu, J. Fan, A. Yang, C. S. Li, N. Lu, Y. Chen, J. Zhao, D. Aa, J. Chen, X. Epigallocatechin-3-gallate decreases the transport and metabolism of simvastatin in rats. Xenobiotica, In process, . (PMID: 27052517)

Yang, C. S. Chen, J. X. Wang, H. Lim, J. Lessons Learned from Cancer Prevention Studies with Nutrients and Non-Nutritive Dietary Constituents. Mol Nutr Food Res, In process, . (PMID: 26865098)

Meyskens, F. L. Jr Mukhtar, H. Rock, C. L. Cuzick, J. Kensler, T. W. Yang, C. S. Ramsey, S. D. Lippman, S. M. Alberts, D. S. Cancer Prevention: Obstacles, Challenges and the Road Ahead. J Natl Cancer Inst, 108:, . (PMID: 26547931)

Yang, C. S. Zhang, J. Zhang, L. Huang, J. Wang, Y. Mechanisms of body weight reduction and metabolic syndrome alleviation by tea. Mol Nutr Food Res, In process, . (PMID: 26577614)

Chen, J. X. Li, G. Wang, H. Liu, A. Lee, M. J. Reuhl, K. Suh, N. Bosland, M. C. Yang, C. S. Dietary tocopherols inhibit PhIP-induced prostate carcinogenesis in CYP1A-humanized mice. Cancer Lett, In process, . (PMID: 26582657)

Joe, A. K. Schnoll-Sussman, F. Bresalier, R. S. Abrams, J. A. Hibshoosh, H. H. Cheung, Y. K. Friedman, R. A. Yang, C. S. Milne, G. L. Liu, D. Lee, J. J. Abdul, K. Bigg, M. Foreman, J. T. Su, T. Wang, X. Ahmed, A. Neugut, A. I. Akpa, E. G. Lippman, S. M. Perloff, M. Brown, P. H. Lightdale, C. J. Phase Ib Randomized, Double-Blinded, Placebo-Controlled, Dose Escalation Study of Polyphenon E in Patients with Barrett's Esophagus. Cancer Prev Res (Phila), In process, . (PMID: 26471236)

Wang, H. Hong, J. Yang, C. S. delta-Tocopherol inhibits receptor tyrosine kinase-induced AKT activation in prostate cancer cells. Mol Carcinog, In process, . (PMID: 26465359)

Wang, D. Wei, Y. Wang, T. Wan, X. Yang, C. S. Reiter, R. J. Zhang, J. Melatonin attenuates (-)-epigallocatehin-3-gallate triggered hepatotoxicity without compromising its downregulation of hepatic gluconeogenic and lipogenic genes in mice. J Pineal Res, In process, . (PMID: 26426126)

Samavat, H. Dostal, A. M. Wang, R. Bedell, S. Emory, T. H. Ursin, G. Torkelson, C. J. Gross, M. D. Le, C. T. Yu, M. C. Yang, C. S. Yee, D. Wu, A. H. Yuan, J. M. Kurzer, M. S. The Minnesota Green Tea Trial (MGTT), a randomized controlled trial of the efficacy of green tea extract on biomarkers of breast cancer risk: study rationale, design, methods, and participant characteristics. Cancer Causes Control, 26:1405-1419, . (PMID: 26206423, PMCID: PMC4567901)

Das Gupta, S. Sae-Tan, S. Wahler, J. So, J. Y. Bak, M. J. Cheng, L. C. Lee, M. J. Lin, Y. Shih, W. J. Shull, J. D. Safe, S. Yang, C. S. Suh, N. Dietary gamma-Tocopherol Rich Mixture Inhibits Estrogen-Induced Mammary Tumorigenesis by Modulating Estrogen Metabolism, Antioxidant Response and PPARgamma. Cancer Prev Res (Phila), In process, . (PMID: 26130252)

Yu, S. Yang, C. S. Li, J. You, W. Chen, J. G. Cao, Y. Dong, Z. Qiao, Y. L. Cancer Prevention Research in China. Cancer Prev Res (Phila), In process, . (PMID: 26076697)

Yue, W. Zheng, X. Lin, Y. Yang, C. S. Xu, Q. Carpizo, D. Huang, H. DiPaola, R. S. Tan, X. L. Metformin combined with aspirin significantly inhibit pancreatic cancer cell growth in vitro and in vivo by suppressing anti-apoptotic proteins Mcl-1 and Bcl-2. Oncotarget, In process, . (PMID: 26056043)

Wang, D. Wang, Y. Wan, X. Yang, C. S. Zhang, J. Green tea polyphenol (-)-epigallocatechin-3-gallate triggered hepatotoxicity in mice: Responses of major antioxidant enzymes and the Nrf2 rescue pathway. Toxicol Appl Pharmacol, In process, . (PMID: 25585349)

Wang, X. Jiang, P. Wang, P. Yang, C. S. Wang, X. Feng, Q. EGCG Enhances Cisplatin Sensitivity by Regulating Expression of the Copper and Cisplatin Influx Transporter CTR1 in Ovary Cancer. PLoS One, 10:e0125402, . (PMID: 25927922)

Yue, W. Wang, T. Zachariah, E. Lin, Y. Yang, C. S. Xu, Q. DiPaola, R. S. Tan, X. L. Transcriptomic analysis of pancreatic cancer cells in response to metformin and aspirin: an implication of synergy. Sci Rep, 5:13390, . (PMID: 26294325)

Jin, H. Chen, J. X. Wang, H. Lu, G. Liu, A. Li, G. Tu, S. Lin, Y. Yang, C. S. NNK-Induced DNA Methyltransferase 1 in Lung Tumorigenesis in A/J Mice and Inhibitory Effects of (-)-Epigallocatechin-3-Gallate. Nutr Cancer, In process, . (PMID: 25437343)

Huang, H. He, Y. Cui, X. X. Goodin, S. Wang, H. Du, Z. Y. Li, D. Zhang, K. Tony Kong, A. N. DiPaola, R. S. Yang, C. S. Conney, A. H. Zheng, X. Potent Inhibitory Effect of delta-Tocopherol on Prostate Cancer Cells Cultured in Vitro and Grown As Xenograft Tumors in Vivo. J Agric Food Chem, 62:10752-10758, . (PMID: 25322450)

Yang, C. S. Feng, Q. Chemo/Dietary prevention of cancer: perspectives in China. J Biomed Res, 28:447-455, . (PMID: 25469113, PMCID: PMC4250523)

Oh, S. Gwak, J. Park, S. Yang, C. S. Green tea polyphenol EGCG suppresses Wnt/beta-catenin signaling by promoting GSK-3beta- and PP2A-independent beta-catenin phosphorylation/degradation. Biofactors, In process, . (PMID: 25352148)

Sakamori, R. Yu, S. Zhang, X. Hoffman, A. Sun, J. Das, S. Vedula, P. Li, G. Fu, J. Walker, F. Yang, C. S. Yi, Z. Hsu, W. Yu, D. H. Shen, L. Rodriguez, A. J. Taketo, M. M. Bonder, E. M. Verzi, M. P. Gao, N. CDC42 inhibition suppresses progression of incipient intestinal tumors. Cancer Res, 74:5480-5492, . (PMID: 25113996, PMCID: PMC4184946)

Wang, H. Zhou, H. Liu, A. Guo, X. Yang, C. S. Genetic analysis of colon tumors induced by a dietary carcinogen PhIP in CYP1A humanized mice: Identification of mutation of beta-catenin/Ctnnb1 as the driver gene for the carcinogenesis. Mol Carcinog, In process, . (PMID: 25131582)

Zhu, H. Zhang, H. Jin, F. Fang, M. Huang, M. Yang, C. S. Chen, T. Fu, L. Pan, Z. Elevated Orai1 expression mediates tumor-promoting intracellular Ca2+ oscillations in human esophageal squamous cell carcinoma. Oncotarget, 5:3455-3471, . (PMID: 24797725, PMCID: PMC4116495)

Yang, C. Xiao, Y. Wang, Z. Wang, S. Chen, L. Wu, L. Liu, G. UHPLC-ESI-MS/MS determination and pharmacokinetic study of two alkaloid components in rat plasma after oral administration of the extract of Corydalis bungeana Turcz. J Chromatogr B Analyt Technol Biomed Life Sci, 960:59-66, . (PMID: 24786221)

Das Gupta, S. So, J. Y. Wall, B. Wahler, J. Smolarek, A. K. Sae-Tan, S. Soewono, K. Y. Yu, H. Lee, M. J. Thomas, P. E. Yang, C. S. Suh, N. Tocopherols inhibit oxidative and nitrosative stress in estrogen-induced early mammary hyperplasia in ACI rats. Mol Carcinog, In process, . (PMID: 24782330)

Yue, W. Yang, C. S. Dipaola, R. S. Tan, X. L. Repurposing of metformin and aspirin by targeting AMPK-mTOR and inflammation for pancreatic cancer prevention and treatment. Cancer Prev Res (Phila), 7:388-397, . (PMID: 24520038)

Saba, N. F. Hurwitz, S. J. Kono, S. A. Yang, C. S. Zhao, Y. Chen, Z. Sica, G. Muller, S. Moreno-Williams, R. Lewis, M. Grist, W. Chen, A. Y. Moore, C. E. Owonikoko, T. K. Ramalingam, S. Beitler, J. J. Nannapaneni, S. Shin, H. J. Grandis, J. R. Khuri, F. R. Chen, Z. G. Shin, D. M. Chemoprevention of head and neck cancer with celecoxib and erlotinib: results of a phase ib and pharmacokinetic study. Cancer Prev Res (Phila), 7:283-291, . (PMID: 24085777)

Chen, L. Magesh, S. Wang, H. Yang, C. S. Kong, A. N. Hu, L. Design and synthesis of novel iminothiazinylbutadienols and divinylpyrimidinethiones as ARE inducers. Bioorg Med Chem Lett, 24:940-943, . (PMID: 24398297, PMCID: PMC3936471)

Zhu, L. Cheng, X. Ding, Y. Shi, J. Jin, H. Wang, H. Wu, Y. Ye, J. Lu, Y. Wang, T. C. Yang, C. S. Tu, S. P. Bone marrow-derived myofibroblasts promote colon tumorigenesis through the IL-6/JAK2/STAT3 pathway. Cancer Lett, 343:80-89, . (PMID: 24145153)

Zhou, J. Farah, B. L. Sinha, R. A. Wu, Y. Singh, B. K. Bay, B. H. Yang, C. S. Yen, P. M. Epigallocatechin-3-Gallate (EGCG), a Green Tea Polyphenol, Stimulates Hepatic Autophagy and Lipid Clearance. PLoS One, 9:e87161, . (PMID: 24489859, PMCID: PMC3906112)

Yang, C. S. Chen, G. Wu, Q. Recent Scientific Studies of a Traditional Chinese Medicine, Tea, on Prevention of Chronic Diseases. J Tradit Complement Med, 4:17-23, . (PMID: 24872929, PMCID: PMC4032838)

Shi, J. D. Golden, T. Guo, C. J. Tu, S. P. Scott, P. Lee, M. J. Yang, C. S. Gow, A. J. Tocopherol supplementation reduces NO production and pulmonary inflammatory response to bleomycin. Nitric Oxide, 34:27-36, . (PMID: 23669183, PMCID: PMC3769481)

Yang, C. S. Wang, H. Hu, B. Combination of Chemopreventive Agents in Nanoparticles for Cancer Prevention. Cancer Prev Res (Phila), 6:1011-1014, . (PMID: 24072675)

Dolfi, S. C. Yang, Z. Lee, M. J. Guan, F. Hong, J. Yang, C. S. Inhibitory Effects of Different Forms of Tocopherols, Tocopherol Phosphates, and Tocopherol Quinones on Growth of Colon Cancer Cells. J Agric Food Chem, In process, . (PMID: 23898832)

Su, Z. Y. Khor, T. O. Shu, L. Lee, J. H. Saw, C. L. Wu, T. Y. Huang, Y. Suh, N. Yang, C. S. Conney, A. H. Wu, Q. Kong, A. N. Epigenetic reactivation of Nrf2 in murine prostate cancer TRAMP C1 cells by natural phytochemicals Z-ligustilide and Radix angelica sinensis via promoter CpG demethylation. Chem Res Toxicol, 26:477-485, . (PMID: 23441843)

Yang, C. S. Li, G. Yang, Z. Guan, F. Chen, A. Ju, J. Cancer prevention by tocopherols and tea polyphenols. Cancer Lett, In process, . (PMID: 23403075, PMCID: PMC3713114)

Yang, C. S. Wang, H. Cancer therapy combination: green tea and a phosphodiesterase 5 inhibitor? J Clin Invest, 123:556-558, . (PMID: 23348734, PMCID: PMC3561839)

Shanafelt, T. D. Call, T. G. Zent, C. S. Leis, J. F. LaPlant, B. Bowen, D. A. Roos, M. Laumann, K. Ghosh, A. K. Lesnick, C. Lee, M. J. Yang, C. S. Jelinek, D. F. Erlichman, C. Kay, N. E. Phase 2 trial of daily, oral Polyphenon E in patients with asymptomatic, Rai stage 0 to II chronic lymphocytic leukemia. Cancer, 119:363-370, . (PMID: 22760587)

Yang, C. S. Suh, N. Cancer Prevention by Different Forms of Tocopherols. Top Curr Chem, 329:21-33, . (PMID: 22836899)

Yang, C. S. Hong, J. Prevention of chronic diseases by tea: possible mechanisms and human relevance. Annu Rev Nutr, 33:161-181, . (PMID: 23642203)

Yu, S. S. Spicer, D. V. Hawes, D. Tseng, C. C. Yang, C. S. Pike, M. C. Wu, A. H. Biological effects of green tea capsule supplementation in pre-surgery postmenopausal breast cancer patients. Front Oncol, 3:298, . (PMID: 24380073, PMCID: PMC3861892)

Smolarek, A. K. So, J. Y. Burgess, B. Kong, A. N. Reuhl, K. Lin, Y. Shih, W. J. Li, G. Lee, M. J. Chen, Y. K. Yang, C. S. Suh, N. Dietary Administration of delta- and gamma-Tocopherol Inhibits Tumorigenesis in the Animal Model of Estrogen Receptor-Positive, but not HER-2 Breast Cancer. Cancer Prev Res (Phila), 5:1310-1320, . (PMID: 22964476, PMCID: PMC3491089)

Yang, H. Jia, X. Chen, X. Yang, C. S. Li, N. Time-selective chemoprevention of vitamin E and selenium on esophageal carcinogenesis in rats: the possible role of nuclear factor kappaB signaling pathway. Int J Cancer, 131:1517-1527, . (PMID: 22223226)

Ju, J. Kwak, Y. Hao, X. Yang, C. S. Inhibitory effects of calcium against intestinal cancer in human colon cancer cells and Apc(Min/+) mice. Nutr Res Pract, 6:396-404, . (PMID: 23198018, PMCID: PMC3506870)

Cheung, K. L. Lee, J. H. Khor, T. O. Wu, T. Y. Li, G. X. Chan, J. Yang, C. S. Kong, A. N. Nrf2 knockout enhances intestinal tumorigenesis in Apc(min/+) mice due to attenuation of anti-oxidative stress pathway while potentiates inflammation. Mol Carcinog, In process, . (PMID: 22911891)

Guan, F. Liu, A. B. Li, G. Yang, Z. Sun, Y. Yang, C. S. Ju, J. Deleterious effects of high concentrations of (-)-epigallocatechin-3-gallate and atorvastatin in mice with colon inflammation. Nutr Cancer, 64:847-855, . (PMID: 22716294)

Li, G. Wang, H. Liu, A. B. Cheung, C. Reuhl, K. R. Bosland, M. C. Yang, C. S. Dietary Carcinogen 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine-Induced Prostate Carcinogenesis in CYP1A-Humanized Mice. Cancer Prev Res (Phila), 5:963-972, . (PMID: 22581815)

Yang, C. S. Pan, E. The effects of green tea polyphenols on drug metabolism. Expert Opin Drug Metab Toxicol, 8:677-689, . (PMID: 22509899)

Yang, C. S. Suh, N. Kong, A. N. Does vitamin E prevent or promote cancer? Cancer Prev Res (Phila), 5:701-705, . (PMID: 22490437)

Huang, Y. Khor, T. O. Shu, L. Saw, C. L. Wu, T. Y. Suh, N. Yang, C. S. Kong, A. N. A gamma-tocopherol-rich mixture of tocopherols maintains Nrf2 expression in prostate tumors of TRAMP mice via epigenetic inhibition of CpG methylation. J Nutr, 142:818-823, . (PMID: 22457388, PMCID: PMC3327740)

Guan, F. Li, G. Liu, A. B. Lee, M. J. Yang, Z. Chen, Y. K. Lin, Y. Shih, W. Yang, C. S. delta- and gamma-tocopherols, but not alpha-tocopherol, inhibit colon carcinogenesis in azoxymethane-treated F344 rats. Cancer Prev Res (Phila), 5:644-654, . (PMID: 22366914, PMCID: PMC3324634)

Li, G. Lee, M. J. Liu, A. B. Yang, Z. Lin, Y. Shih, W. J. Yang, C. S. The antioxidant and anti-inflammatory activities of tocopherols are independent of Nrf2 in mice. Free Radic Biol Med, 52:1151-1158, . (PMID: 22226829)

Smolarek, A. K. So, J. Y. Thomas, P. E. Lee, H. J. Paul, S. Dombrowski, A. Wang, C. X. Saw, C. L. Khor, T. O. Kong, A. N. Reuhl, K. Lee, M. J. Yang, C. S. Suh, N. Dietary tocopherols inhibit cell proliferation, regulate expression of ERalpha, PPARgamma, and Nrf2, and decrease serum inflammatory markers during the development of mammary hyperplasia. Mol Carcinog, In process, . (PMID: 22389237, PMCID: PMC3374909)

Wu, A. H. Spicer, D. Stanczyk, F. Z. Tseng, C. C. Yang, C. S. Pike, M. C. Effect of 2-month controlled green tea intervention on lipoprotein cholesterol, glucose, and hormone levels in healthy postmenopausal women. Cancer Prev Res (Phila), 5:393-402, . (PMID: 22246619)

Tu, S. P. Jin, H. Shi, J. D. Zhu, L. M. Suo, Y. Lu, G. Liu, A. Wang, T. C. Yang, C. S. Curcumin induces the differentiation of myeloid-derived suppressor cells and inhibits their interaction with cancer cells and related tumor growth. Cancer Prev Res (Phila), 5:205-215, . (PMID: 22030090, PMCID: PMC3273601)

Yang, Z. Lee, M. J. Zhao, Y. Yang, C. S. Metabolism of tocotrienols in animals and synergistic inhibitory actions of tocotrienols with atorvastatin in cancer cells. Genes Nutr, 7:11-18, . (PMID: 21590436, PMCID: PMC3250521)

Zheng, X. Cui, X. X. Huang, M. T. Liu, Y. Wagner, G. C. Lin, Y. Shih, W. J. Lee, M. J. Yang, C. S. Conney, A. H. Inhibition of Progression of Androgen-Dependent Prostate LNCaP Tumors to Androgen Independence in SCID Mice by Oral Caffeine and Voluntary Exercise. Nutr Cancer, 64:1029-1037, . (PMID: 23061906)

Wang, H. Bian, S. Yang, C. S. Green tea polyphenol EGCG suppresses lung cancer cell growth through upregulating miR-210 expression caused by stabilizing HIF-1alpha. Carcinogenesis, 32:1881-1889, . (PMID: 21965273, PMCID: PMC3220612)

Chen, Y. K. Cheung, C. Reuhl, K. R. Liu, A. B. Lee, M. J. Lu, Y. P. Yang, C. S. Effects of green tea polyphenol (-)-epigallocatechin-3-gallate on newly developed high-fat/Western-style diet-induced obesity and metabolic syndrome in mice. J Agric Food Chem, 59:11862-11871, . (PMID: 21932846, PMCID: PMC3243651)

Yang, C. S. Wang, H. Li, G. X. Yang, Z. Guan, F. Jin, H. Cancer prevention by tea: Evidence from laboratory studies. Pharmacol Res, 64:113-122, . (PMID: 21397027)

Sang, S. Lambert, J. D. Ho, C. T. Yang, C. S. The chemistry and biotransformation of tea constituents. Pharmacol Res, 64:87-99, . (PMID: 21371557)

Yang, C. S. Lambert, J. D. Research on tea and health. Pharmacol Res, 64:85-86, . (PMID: 21651983)

Lotito, S. B. Zhang, W. J. Yang, C. S. Crozier, A. Frei, B. Metabolic conversion of dietary flavonoids alters their anti-inflammatory and antioxidant properties. Free Radic Biol Med, 51:454-463, . (PMID: 21571063, PMCID: PMC3119369)

Yang, C. S. Wang, H. Mechanistic issues concerning cancer prevention by tea catechins. Mol Nutr Food Res, 55:819-831, . (PMID: 21538856)

Li, G. X. Lee, M. J. Liu, A. B. Yang, Z. Lin, Y. Shih, W. J. Yang, C. S. delta-tocopherol is more active than alpha - or gamma -tocopherol in inhibiting lung tumorigenesis in vivo. Cancer Prev Res (Phila), 4:404-413, . (PMID: 21372040, PMCID: PMC3071153)

Zheng, X. Cui, X. X. Gao, Z. Zhao, Y. Shi, Y. Huang, M. T. Liu, Y. Wagner, G. C. Lin, Y. Shih, W. J. Rao, C. V. Yang, C. S. Conney, A. H. Inhibitory effect of dietary atorvastatin and celecoxib together with voluntary running wheel exercise on the progression of androgen-dependent LNCaP prostate tumors to androgen independence. Exp Ther Med, 2:221-228, . (PMID: 21660218, PMCID: PMC3109910)

Cheung, C. Loy, S. Li, G. X. Liu, A. B. Yang, C. S. Rapid induction of colon carcinogenesis in CYP1A-humanized mice by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate. Carcinogenesis, 32:233-239, . (PMID: 21081470, PMCID: PMC3026842)

Zheng, X. Cui, X. X. Khor, T. O. Huang, Y. Dipaola, R. S. Goodin, S. Lee, M. J. Yang, C. S. Kong, A. N. Conney, A. H. Inhibitory Effect of a gamma-Tocopherol-Rich Mixture of Tocopherols on the Formation and Growth of LNCaP Prostate Tumors in Immunodeficient Mice. Cancers (Basel), 3:3762-3772, . (PMID: 24213110, PMCID: PMC3763395)