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Chung S. Yang, PhD

Publications since 2011

Das Gupta, S. Sae-Tan, S. Wahler, J. So, J. Y. Bak, M. J. Cheng, L. C. Lee, M. J. Lin, Y. Shih, W. J. Shull, J. D. Safe, S. Yang, C. S. Suh, N. Dietary gamma-Tocopherol Rich Mixture Inhibits Estrogen-Induced Mammary Tumorigenesis by Modulating Estrogen Metabolism, Antioxidant Response and PPARgamma. Cancer Prev Res (Phila), In process, . (PMID: 26130252)

Yu, S. Yang, C. S. Li, J. You, W. Chen, J. G. Cao, Y. Dong, Z. Qiao, Y. L. Cancer Prevention Research in China. Cancer Prev Res (Phila), In process, . (PMID: 26076697)

Yue, W. Zheng, X. Lin, Y. Yang, C. S. Xu, Q. Carpizo, D. Huang, H. DiPaola, R. S. Tan, X. L. Metformin combined with aspirin significantly inhibit pancreatic cancer cell growth in vitro and in vivo by suppressing anti-apoptotic proteins Mcl-1 and Bcl-2. Oncotarget, In process, . (PMID: 26056043)

Wang, D. Wang, Y. Wan, X. Yang, C. S. Zhang, J. Green tea polyphenol (-)-epigallocatechin-3-gallate triggered hepatotoxicity in mice: Responses of major antioxidant enzymes and the Nrf2 rescue pathway. Toxicol Appl Pharmacol, In process, . (PMID: 25585349)

Wang, X. Jiang, P. Wang, P. Yang, C. S. Wang, X. Feng, Q. EGCG Enhances Cisplatin Sensitivity by Regulating Expression of the Copper and Cisplatin Influx Transporter CTR1 in Ovary Cancer. PLoS One, 10:e0125402, . (PMID: 25927922)

Yue, W. Wang, T. Zachariah, E. Lin, Y. Yang, C. S. Xu, Q. DiPaola, R. S. Tan, X. L. Transcriptomic analysis of pancreatic cancer cells in response to metformin and aspirin: an implication of synergy. Sci Rep, 5:13390, . (PMID: 26294325)

Jin, H. Chen, J. X. Wang, H. Lu, G. Liu, A. Li, G. Tu, S. Lin, Y. Yang, C. S. NNK-Induced DNA Methyltransferase 1 in Lung Tumorigenesis in A/J Mice and Inhibitory Effects of (-)-Epigallocatechin-3-Gallate. Nutr Cancer, In process, . (PMID: 25437343)

Huang, H. He, Y. Cui, X. X. Goodin, S. Wang, H. Du, Z. Y. Li, D. Zhang, K. Tony Kong, A. N. DiPaola, R. S. Yang, C. S. Conney, A. H. Zheng, X. Potent Inhibitory Effect of delta-Tocopherol on Prostate Cancer Cells Cultured in Vitro and Grown As Xenograft Tumors in Vivo. J Agric Food Chem, 62:10752-10758, . (PMID: 25322450)

Yang, C. S. Feng, Q. Chemo/Dietary prevention of cancer: perspectives in China. J Biomed Res, 28:447-455, . (PMID: 25469113, PMCID: PMC4250523)

Oh, S. Gwak, J. Park, S. Yang, C. S. Green tea polyphenol EGCG suppresses Wnt/beta-catenin signaling by promoting GSK-3beta- and PP2A-independent beta-catenin phosphorylation/degradation. Biofactors, In process, . (PMID: 25352148)

Sakamori, R. Yu, S. Zhang, X. Hoffman, A. Sun, J. Das, S. Vedula, P. Li, G. Fu, J. Walker, F. Yang, C. S. Yi, Z. Hsu, W. Yu, D. H. Shen, L. Rodriguez, A. J. Taketo, M. M. Bonder, E. M. Verzi, M. P. Gao, N. CDC42 inhibition suppresses progression of incipient intestinal tumors. Cancer Res, 74:5480-5492, . (PMID: 25113996, PMCID: PMC4184946)

Wang, H. Zhou, H. Liu, A. Guo, X. Yang, C. S. Genetic analysis of colon tumors induced by a dietary carcinogen PhIP in CYP1A humanized mice: Identification of mutation of beta-catenin/Ctnnb1 as the driver gene for the carcinogenesis. Mol Carcinog, In process, . (PMID: 25131582)

Zhu, H. Zhang, H. Jin, F. Fang, M. Huang, M. Yang, C. S. Chen, T. Fu, L. Pan, Z. Elevated Orai1 expression mediates tumor-promoting intracellular Ca2+ oscillations in human esophageal squamous cell carcinoma. Oncotarget, 5:3455-3471, . (PMID: 24797725, PMCID: PMC4116495)

Yang, C. Xiao, Y. Wang, Z. Wang, S. Chen, L. Wu, L. Liu, G. UHPLC-ESI-MS/MS determination and pharmacokinetic study of two alkaloid components in rat plasma after oral administration of the extract of Corydalis bungeana Turcz. J Chromatogr B Analyt Technol Biomed Life Sci, 960:59-66, . (PMID: 24786221)

Das Gupta, S. So, J. Y. Wall, B. Wahler, J. Smolarek, A. K. Sae-Tan, S. Soewono, K. Y. Yu, H. Lee, M. J. Thomas, P. E. Yang, C. S. Suh, N. Tocopherols inhibit oxidative and nitrosative stress in estrogen-induced early mammary hyperplasia in ACI rats. Mol Carcinog, In process, . (PMID: 24782330)

Yue, W. Yang, C. S. Dipaola, R. S. Tan, X. L. Repurposing of metformin and aspirin by targeting AMPK-mTOR and inflammation for pancreatic cancer prevention and treatment. Cancer Prev Res (Phila), 7:388-397, . (PMID: 24520038)

Saba, N. F. Hurwitz, S. J. Kono, S. A. Yang, C. S. Zhao, Y. Chen, Z. Sica, G. Muller, S. Moreno-Williams, R. Lewis, M. Grist, W. Chen, A. Y. Moore, C. E. Owonikoko, T. K. Ramalingam, S. Beitler, J. J. Nannapaneni, S. Shin, H. J. Grandis, J. R. Khuri, F. R. Chen, Z. G. Shin, D. M. Chemoprevention of head and neck cancer with celecoxib and erlotinib: results of a phase ib and pharmacokinetic study. Cancer Prev Res (Phila), 7:283-291, . (PMID: 24085777)

Chen, L. Magesh, S. Wang, H. Yang, C. S. Kong, A. N. Hu, L. Design and synthesis of novel iminothiazinylbutadienols and divinylpyrimidinethiones as ARE inducers. Bioorg Med Chem Lett, 24:940-943, . (PMID: 24398297, PMCID: PMC3936471)

Zhu, L. Cheng, X. Ding, Y. Shi, J. Jin, H. Wang, H. Wu, Y. Ye, J. Lu, Y. Wang, T. C. Yang, C. S. Tu, S. P. Bone marrow-derived myofibroblasts promote colon tumorigenesis through the IL-6/JAK2/STAT3 pathway. Cancer Lett, 343:80-89, . (PMID: 24145153)

Zhou, J. Farah, B. L. Sinha, R. A. Wu, Y. Singh, B. K. Bay, B. H. Yang, C. S. Yen, P. M. Epigallocatechin-3-Gallate (EGCG), a Green Tea Polyphenol, Stimulates Hepatic Autophagy and Lipid Clearance. PLoS One, 9:e87161, . (PMID: 24489859, PMCID: PMC3906112)

Yang, C. S. Chen, G. Wu, Q. Recent Scientific Studies of a Traditional Chinese Medicine, Tea, on Prevention of Chronic Diseases. J Tradit Complement Med, 4:17-23, . (PMID: 24872929, PMCID: PMC4032838)

Shi, J. D. Golden, T. Guo, C. J. Tu, S. P. Scott, P. Lee, M. J. Yang, C. S. Gow, A. J. Tocopherol supplementation reduces NO production and pulmonary inflammatory response to bleomycin. Nitric Oxide, 34:27-36, . (PMID: 23669183, PMCID: PMC3769481)

Yang, C. S. Wang, H. Hu, B. Combination of Chemopreventive Agents in Nanoparticles for Cancer Prevention. Cancer Prev Res (Phila), 6:1011-1014, . (PMID: 24072675)

Dolfi, S. C. Yang, Z. Lee, M. J. Guan, F. Hong, J. Yang, C. S. Inhibitory Effects of Different Forms of Tocopherols, Tocopherol Phosphates, and Tocopherol Quinones on Growth of Colon Cancer Cells. J Agric Food Chem, In process, . (PMID: 23898832)

Su, Z. Y. Khor, T. O. Shu, L. Lee, J. H. Saw, C. L. Wu, T. Y. Huang, Y. Suh, N. Yang, C. S. Conney, A. H. Wu, Q. Kong, A. N. Epigenetic reactivation of Nrf2 in murine prostate cancer TRAMP C1 cells by natural phytochemicals Z-ligustilide and Radix angelica sinensis via promoter CpG demethylation. Chem Res Toxicol, 26:477-485, . (PMID: 23441843)

Yang, C. S. Li, G. Yang, Z. Guan, F. Chen, A. Ju, J. Cancer prevention by tocopherols and tea polyphenols. Cancer Lett, In process, . (PMID: 23403075, PMCID: PMC3713114)

Yang, C. S. Wang, H. Cancer therapy combination: green tea and a phosphodiesterase 5 inhibitor? J Clin Invest, 123:556-558, . (PMID: 23348734, PMCID: PMC3561839)

Shanafelt, T. D. Call, T. G. Zent, C. S. Leis, J. F. LaPlant, B. Bowen, D. A. Roos, M. Laumann, K. Ghosh, A. K. Lesnick, C. Lee, M. J. Yang, C. S. Jelinek, D. F. Erlichman, C. Kay, N. E. Phase 2 trial of daily, oral Polyphenon E in patients with asymptomatic, Rai stage 0 to II chronic lymphocytic leukemia. Cancer, 119:363-370, . (PMID: 22760587)

Yang, C. S. Suh, N. Cancer Prevention by Different Forms of Tocopherols. Top Curr Chem, 329:21-33, . (PMID: 22836899)

Yang, C. S. Hong, J. Prevention of chronic diseases by tea: possible mechanisms and human relevance. Annu Rev Nutr, 33:161-181, . (PMID: 23642203)

Yu, S. S. Spicer, D. V. Hawes, D. Tseng, C. C. Yang, C. S. Pike, M. C. Wu, A. H. Biological effects of green tea capsule supplementation in pre-surgery postmenopausal breast cancer patients. Front Oncol, 3:298, . (PMID: 24380073, PMCID: PMC3861892)

Smolarek, A. K. So, J. Y. Burgess, B. Kong, A. N. Reuhl, K. Lin, Y. Shih, W. J. Li, G. Lee, M. J. Chen, Y. K. Yang, C. S. Suh, N. Dietary Administration of delta- and gamma-Tocopherol Inhibits Tumorigenesis in the Animal Model of Estrogen Receptor-Positive, but not HER-2 Breast Cancer. Cancer Prev Res (Phila), 5:1310-1320, . (PMID: 22964476, PMCID: PMC3491089)

Yang, H. Jia, X. Chen, X. Yang, C. S. Li, N. Time-selective chemoprevention of vitamin E and selenium on esophageal carcinogenesis in rats: the possible role of nuclear factor kappaB signaling pathway. Int J Cancer, 131:1517-1527, . (PMID: 22223226)

Ju, J. Kwak, Y. Hao, X. Yang, C. S. Inhibitory effects of calcium against intestinal cancer in human colon cancer cells and Apc(Min/+) mice. Nutr Res Pract, 6:396-404, . (PMID: 23198018, PMCID: PMC3506870)

Cheung, K. L. Lee, J. H. Khor, T. O. Wu, T. Y. Li, G. X. Chan, J. Yang, C. S. Kong, A. N. Nrf2 knockout enhances intestinal tumorigenesis in Apc(min/+) mice due to attenuation of anti-oxidative stress pathway while potentiates inflammation. Mol Carcinog, In process, . (PMID: 22911891)

Guan, F. Liu, A. B. Li, G. Yang, Z. Sun, Y. Yang, C. S. Ju, J. Deleterious effects of high concentrations of (-)-epigallocatechin-3-gallate and atorvastatin in mice with colon inflammation. Nutr Cancer, 64:847-855, . (PMID: 22716294)

Li, G. Wang, H. Liu, A. B. Cheung, C. Reuhl, K. R. Bosland, M. C. Yang, C. S. Dietary Carcinogen 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine-Induced Prostate Carcinogenesis in CYP1A-Humanized Mice. Cancer Prev Res (Phila), 5:963-972, . (PMID: 22581815)

Yang, C. S. Pan, E. The effects of green tea polyphenols on drug metabolism. Expert Opin Drug Metab Toxicol, 8:677-689, . (PMID: 22509899)

Yang, C. S. Suh, N. Kong, A. N. Does vitamin E prevent or promote cancer? Cancer Prev Res (Phila), 5:701-705, . (PMID: 22490437)

Huang, Y. Khor, T. O. Shu, L. Saw, C. L. Wu, T. Y. Suh, N. Yang, C. S. Kong, A. N. A gamma-tocopherol-rich mixture of tocopherols maintains Nrf2 expression in prostate tumors of TRAMP mice via epigenetic inhibition of CpG methylation. J Nutr, 142:818-823, . (PMID: 22457388, PMCID: PMC3327740)

Guan, F. Li, G. Liu, A. B. Lee, M. J. Yang, Z. Chen, Y. K. Lin, Y. Shih, W. Yang, C. S. delta- and gamma-tocopherols, but not alpha-tocopherol, inhibit colon carcinogenesis in azoxymethane-treated F344 rats. Cancer Prev Res (Phila), 5:644-654, . (PMID: 22366914, PMCID: PMC3324634)

Li, G. Lee, M. J. Liu, A. B. Yang, Z. Lin, Y. Shih, W. J. Yang, C. S. The antioxidant and anti-inflammatory activities of tocopherols are independent of Nrf2 in mice. Free Radic Biol Med, 52:1151-1158, . (PMID: 22226829)

Smolarek, A. K. So, J. Y. Thomas, P. E. Lee, H. J. Paul, S. Dombrowski, A. Wang, C. X. Saw, C. L. Khor, T. O. Kong, A. N. Reuhl, K. Lee, M. J. Yang, C. S. Suh, N. Dietary tocopherols inhibit cell proliferation, regulate expression of ERalpha, PPARgamma, and Nrf2, and decrease serum inflammatory markers during the development of mammary hyperplasia. Mol Carcinog, In process, . (PMID: 22389237, PMCID: PMC3374909)

Wu, A. H. Spicer, D. Stanczyk, F. Z. Tseng, C. C. Yang, C. S. Pike, M. C. Effect of 2-month controlled green tea intervention on lipoprotein cholesterol, glucose, and hormone levels in healthy postmenopausal women. Cancer Prev Res (Phila), 5:393-402, . (PMID: 22246619)

Tu, S. P. Jin, H. Shi, J. D. Zhu, L. M. Suo, Y. Lu, G. Liu, A. Wang, T. C. Yang, C. S. Curcumin induces the differentiation of myeloid-derived suppressor cells and inhibits their interaction with cancer cells and related tumor growth. Cancer Prev Res (Phila), 5:205-215, . (PMID: 22030090, PMCID: PMC3273601)

Yang, Z. Lee, M. J. Zhao, Y. Yang, C. S. Metabolism of tocotrienols in animals and synergistic inhibitory actions of tocotrienols with atorvastatin in cancer cells. Genes Nutr, 7:11-18, . (PMID: 21590436, PMCID: PMC3250521)

Zheng, X. Cui, X. X. Huang, M. T. Liu, Y. Wagner, G. C. Lin, Y. Shih, W. J. Lee, M. J. Yang, C. S. Conney, A. H. Inhibition of Progression of Androgen-Dependent Prostate LNCaP Tumors to Androgen Independence in SCID Mice by Oral Caffeine and Voluntary Exercise. Nutr Cancer, 64:1029-1037, . (PMID: 23061906)

Wang, H. Bian, S. Yang, C. S. Green tea polyphenol EGCG suppresses lung cancer cell growth through upregulating miR-210 expression caused by stabilizing HIF-1alpha. Carcinogenesis, 32:1881-1889, . (PMID: 21965273, PMCID: PMC3220612)

Chen, Y. K. Cheung, C. Reuhl, K. R. Liu, A. B. Lee, M. J. Lu, Y. P. Yang, C. S. Effects of green tea polyphenol (-)-epigallocatechin-3-gallate on newly developed high-fat/Western-style diet-induced obesity and metabolic syndrome in mice. J Agric Food Chem, 59:11862-11871, . (PMID: 21932846, PMCID: PMC3243651)

Yang, C. S. Wang, H. Li, G. X. Yang, Z. Guan, F. Jin, H. Cancer prevention by tea: Evidence from laboratory studies. Pharmacol Res, 64:113-122, . (PMID: 21397027)

Sang, S. Lambert, J. D. Ho, C. T. Yang, C. S. The chemistry and biotransformation of tea constituents. Pharmacol Res, 64:87-99, . (PMID: 21371557)

Yang, C. S. Lambert, J. D. Research on tea and health. Pharmacol Res, 64:85-86, . (PMID: 21651983)

Lotito, S. B. Zhang, W. J. Yang, C. S. Crozier, A. Frei, B. Metabolic conversion of dietary flavonoids alters their anti-inflammatory and antioxidant properties. Free Radic Biol Med, 51:454-463, . (PMID: 21571063, PMCID: PMC3119369)

Yang, C. S. Wang, H. Mechanistic issues concerning cancer prevention by tea catechins. Mol Nutr Food Res, 55:819-831, . (PMID: 21538856)

Li, G. X. Lee, M. J. Liu, A. B. Yang, Z. Lin, Y. Shih, W. J. Yang, C. S. delta-tocopherol is more active than alpha - or gamma -tocopherol in inhibiting lung tumorigenesis in vivo. Cancer Prev Res (Phila), 4:404-413, . (PMID: 21372040, PMCID: PMC3071153)

Zheng, X. Cui, X. X. Gao, Z. Zhao, Y. Shi, Y. Huang, M. T. Liu, Y. Wagner, G. C. Lin, Y. Shih, W. J. Rao, C. V. Yang, C. S. Conney, A. H. Inhibitory effect of dietary atorvastatin and celecoxib together with voluntary running wheel exercise on the progression of androgen-dependent LNCaP prostate tumors to androgen independence. Exp Ther Med, 2:221-228, . (PMID: 21660218, PMCID: PMC3109910)

Cheung, C. Loy, S. Li, G. X. Liu, A. B. Yang, C. S. Rapid induction of colon carcinogenesis in CYP1A-humanized mice by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate. Carcinogenesis, 32:233-239, . (PMID: 21081470, PMCID: PMC3026842)

Zheng, X. Cui, X. X. Khor, T. O. Huang, Y. Dipaola, R. S. Goodin, S. Lee, M. J. Yang, C. S. Kong, A. N. Conney, A. H. Inhibitory Effect of a gamma-Tocopherol-Rich Mixture of Tocopherols on the Formation and Growth of LNCaP Prostate Tumors in Immunodeficient Mice. Cancers (Basel), 3:3762-3772, . (PMID: 24213110, PMCID: PMC3763395)