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Kuang-Yu Chen, PhD

Selected Publications

Tao, Y. and Chen, K.Y.  Purification of deoxyhypusine synthase from Neurospora crassa to homogeneity by substrate elution affinity chromatography.  J. Biol. Chem., 270, 383-386, 1995.

Tao, Y. and Chen, K.Y.  Molecular cloning and functional expression of Neurospora  deoxyhypusine synthase cDNA and identification of yeast ,deoxyhypusine synthase cDNA.  J. Biol. Chem., 270, 23984-23987, 1995.

Chen, Z.P., Yan, Y.P., Ding, Q., Potenza, J.A., Knapp, S., Schugar, H.J. Chen, K.Y.  Effects ofinhibitors of deoxyhypusine synthase on the differentiation of mouse neuroblastoma and erythroleukemia cells.  Cancer Letters, 105, 233-239, 1996.

Caruccio, L., Bae, S.,  Liu, A.Y-C. and Chen, K.Y.  Rapid activation of the heat shock factor, HSF1, by hyper- and hypo-osmotic stress in mammalian cells. Biochemical J.,  327, 341-347, 1997.

Chen, Z..P. and Chen K.Y. Marked elevation of hypusine formation activity on eukaryotic initiation factor 5A in v-HA-RAS transformed mouse NIH3T3 cells. Cancer Lett. 115, 235-241, 1997.

Chen, K.Y. and Liu, A.Y.-C.  Hypusine formation on eukaryotic initiation factor 5A, biochemistry andfunction.  Biol. Signals, 6, 105-109, 1997.

Chen, K.Y.  Study of polyphosphate metabolism by 31P nuclear magnetic resonance spectroscopy. in “Progesss in Molecular and Subcellular Biology” (ed. Schroder, H.C.), Springer Verlag, Germany, pp. 253-273, 1999

Lu, J.B., Park, J., Liu, A.Y-C. and Chen, K.Y.  Osmotic stress-induced activation of HSF1 DNA binding activity is dramatically attenuated in senescent human cells.  J. Cell. Physiol., 184, 183-190, 2000.

Matuoka, K. and Chen, K.Y.  Possible role of subunit A of nuclear factor Y (NF-Y) in normal human diploid fibroblasts during senescence. Biogerontology, 1, 261-271, 2000.

Lu, J.B., Ho, C.-T. , Ghai, G. and Chen, K.Y.  Differential effects of theaflavin monogallates on cell growth, apoptosis and Cox-2 gene expression in cancerous versus normal cells.  Cancer Research, 60, 6465-6471, 2000.

Lu, J., Chen, Z.P., Yan, Y.P., Knapp, S., Schugar, H. and Chen, K.Y.  6-Aminohexanoic hydroxamate is a potent inducer of the differentiation of mouse neuroblastoma cells. Cancer Lett.,  160, 59-66,2000.

Xu, A. and Chen, K.Y. Hypusine is required for a sequence-specific interaction of eukaryotic initiation factor 5A with post-SELEX RNA. J. Biol Chem., 276, 2555-2561, 2001.

Lu, J.B., Ho, C.-T. , Ghai, G. and Chen, K.Y. Resveratrol analog, 3, 4, 4', 5-tetrahydroxystilbene, differentially induces pro-apoptotic p53/Bax gene expression and inhibits the growth of transformed cells but not their normal counterparts.   Carcinogenesis, 22, 321-328, 2001.

Matuoka, K., Chen, K.Y. and Takenawa, T.  Rapid reversion of aging phenotypes by nicotinamide through possible modulation of histone acetylation.  Cell. Mol. Life Sciences, 58, 2108-2116, 2001.

Jao, D.L. and Chen, K.Y.  Subcellular localization of the hypusine-containing eukaryotic initiation factor 5A by immunofluorescent staining and Green Fluorescent protein tagging.  J. Cell. Biochem., 86, 590-600, 2002.