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Robert S. DiPaola, MD

Publications since 2011

McNeel, D. G. Chen, Y. H. Gulley, J. L. Dwyer, A. J. Madan, R. A. Carducci, M. A. DiPaola, R. S. Randomized phase II trial of docetaxel with or without PSA-TRICOM vaccine in patients with castrate-resistant metastatic prostate cancer: A trial of the ECOG-ACRIN cancer research group (E1809). Hum Vaccin Immunother, 11:2469-2474, . (PMID: 26111351, PMCID: PMC4635940)

Stein, M. N. Hussain, M. Stadler, W. M. Liu, G. Tereshchenko, I. V. Goodin, S. Jeyamohan, C. Kaufman, H. L. Mehnert, J. DiPaola, R. S. A Phase II Study of AT-101 to Overcome Bcl-2-Mediated Resistance to Androgen Deprivation Therapy in Patients With Newly Diagnosed Castration-Sensitive Metastatic Prostate Cancer. Clin Genitourin Cancer, In process, . (PMID: 26476589)

Sweeney, C. J. Chen, Y. H. Carducci, M. Liu, G. Jarrard, D. F. Eisenberger, M. Wong, Y. N. Hahn, N. Kohli, M. Cooney, M. M. Dreicer, R. Vogelzang, N. J. Picus, J. Shevrin, D. Hussain, M. Garcia, J. A. DiPaola, R. S. Chemohormonal Therapy in Metastatic Hormone-Sensitive Prostate Cancer. N Engl J Med, In process, . (PMID: 26244877)

Lu-Yao, G. L. Kim, S. Moore, D. F. Shih, W. Lin, Y. DiPaola, R. S. Shen, S. Zietman, A. Yao, S. L. Primary radiotherapy vs conservative management for localized prostate cancer-a population-based study. Prostate Cancer Prostatic Dis, In process, . (PMID: 26101187)

Flaherty, K. T. Manola, J. B. Pins, M. McDermott, D. F. Atkins, M. B. Dutcher, J. J. George, D. J. Margolin, K. A. DiPaola, R. S. BEST: A Randomized Phase II Study of Vascular Endothelial Growth Factor, RAF Kinase, and Mammalian Target of Rapamycin Combination Targeted Therapy With Bevacizumab, Sorafenib, and Temsirolimus in Advanced Renal Cell Carcinoma-A Trial of the ECOG-ACRIN Cancer Research Group (E2804). J Clin Oncol, In process, . (PMID: 26077237)

Bansal, N. Mishra, P. J. Stein, M. DiPaola, R. S. Bertino, J. R. Axl receptor tyrosine kinase is up-regulated in metformin resistant prostate cancer cells. Oncotarget, In process, . (PMID: 26036314)

Haas, N. Manola, J. Ky, B. Flaherty, K. T. Uzzo, R. G. Kane, C. Jewett, M. A. Wood, L. Wood, C. G. Atkins, M. B. Dutcher, J. P. Wilding, G. DiPaola, R. Effects of adjuvant sorafenib and sunitinib on cardiac function in renal cell carcinoma patients without overt metastases:results from ASSURE, ECOG2805. Clin Cancer Res, In process, . (PMID: 25967143)

Yue, W. Zheng, X. Lin, Y. Yang, C. S. Xu, Q. Carpizo, D. Huang, H. DiPaola, R. S. Tan, X. L. Metformin combined with aspirin significantly inhibit pancreatic cancer cell growth in vitro and in vivo by suppressing anti-apoptotic proteins Mcl-1 and Bcl-2. Oncotarget, In process, . (PMID: 26056043)

Lu-Yao, G. L. Albertsen, P. C. Moore, D. F. Lin, Y. DiPaola, R. S. Yao, S. L. Fifteen-year Outcomes Following Conservative Management Among Men Aged 65 Years or Older with Localized Prostate Cancer. Eur Urol, In process, . (PMID: 25800944)

Hussain, M. DiPaola, R. S. Clinical research in metastatic prostate cancer: a focus on impact and value. Am Soc Clin Oncol Educ Book, 35:17-21, . (PMID: 25993136)

Yue, W. Wang, T. Zachariah, E. Lin, Y. Yang, C. S. Xu, Q. DiPaola, R. S. Tan, X. L. Transcriptomic analysis of pancreatic cancer cells in response to metformin and aspirin: an implication of synergy. Sci Rep, 5:13390, . (PMID: 26294325)

Huang, H. Chen, X. Li, D. He, Y. Li, Y. Du, Z. Zhang, K. DiPaola, R. Goodin, S. Zheng, X. Combination of alpha-Tomatine and Curcumin Inhibits Growth and Induces Apoptosis in Human Prostate Cancer Cells. PLoS One, 10:e0144293, . (PMID: 26630272)

DiPaola, R. S. Chen, Y. Bubley, G. J. Stein, M. N. Hahn, N. M. Carducci, M. A. Lattime, E. C. Gulley, J. L. Arlen, P. M. Butterfield, L. H. Wilding, G. A National Multicenter Phase 2 Study of Prostate-specific Antigen (PSA) Pox Virus Vaccine with Sequential Androgen Ablation Therapy in Patients with PSA Progression: ECOG 9802. Eur Urol, In process, . (PMID: 25533418)

Huang, H. He, Y. Cui, X. X. Goodin, S. Wang, H. Du, Z. Y. Li, D. Zhang, K. Tony Kong, A. N. DiPaola, R. S. Yang, C. S. Conney, A. H. Zheng, X. Potent Inhibitory Effect of delta-Tocopherol on Prostate Cancer Cells Cultured in Vitro and Grown As Xenograft Tumors in Vivo. J Agric Food Chem, 62:10752-10758, . (PMID: 25322450)

Tereshchenko, I. V. Zhong, H. Chekmareva, M. A. Kane-Goldsmith, N. Santanam, U. Petrosky, W. Stein, M. N. Ganesan, S. Singer, E. A. Moore, D. Tischfield, J. A. DiPaola, R. S. ERG and CHD1 heterogeneity in prostate cancer: Use of confocal microscopy in assessment of microscopic foci. Prostate, 74:1551-1559, . (PMID: 25175909, PMCID: PMC4181586)

Song, M. DiPaola, R. S. Cracchiolo, B. M. Gibbon, D. G. Hellmann, M. Nieves-Neira, W. Vaidya, A. Wagreich, A. R. Shih, W. J. Rodriguez-Rodriguez, L. Phase 2 Trial of Paclitaxel, 13-cis Retinoic Acid, and Interferon Alfa-2b in the Treatment of Advanced Stage or Recurrent Cervical Cancer. Int J Gynecol Cancer, 24:1636-1641, . (PMID: 25304678, PMCID: PMC4211961)

Lu-Yao, G. L. Albertsen, P. C. Moore, D. F. Shih, W. Lin, Y. DiPaola, R. S. Yao, S. L. Fifteen-Year Survival Outcomes Following Primary Androgen-Deprivation Therapy for Localized Prostate Cancer. JAMA Intern Med, 174:1460-1467, . (PMID: 25023796)

Richie, J. P. Das, A. Calcagnotto, A. Sinha, R. Neidig, W. Liao, J. Lengerich, E. J. Berg, A. Hartman, T. J. Ciccarella, A. Baker, A. Kaag, M. G. Goodin, S. DiPaola, R. S. El-Bayoumy, K. Comparative effects of two different forms of selenium on oxidative stress biomarkers in healthy men: a randomized clinical trial. Cancer Prev Res (Phila), 7:796-804, . (PMID: 24938534, PMCID: PMC4125492)

Huang, H. Cui, X. X. Chen, S. Goodin, S. Liu, Y. He, Y. Li, D. Wang, H. VAN Doren, J. Dipaola, R. S. Conney, A. H. Zheng, X. Combination of Lipitor and Celebrex Inhibits Prostate Cancer VCaP Cells In Vitro and In Vivo. Anticancer Res, 34:3357-3363, . (PMID: 24982340)

Pillai, R. N. Aisner, J. Dahlberg, S. E. Rogers, J. S. DiPaola, R. S. Aisner, S. Ramalingam, S. S. Schiller, J. H. Interferon alpha plus 13-cis-retinoic acid modulation of BCL-2 plus paclitaxel for recurrent small-cell lung cancer (SCLC): an Eastern Cooperative Oncology Group study (E6501). Cancer Chemother Pharmacol, 74:177-183, . (PMID: 24858462)

Yue, W. Yang, C. S. Dipaola, R. S. Tan, X. L. Repurposing of metformin and aspirin by targeting AMPK-mTOR and inflammation for pancreatic cancer prevention and treatment. Cancer Prev Res (Phila), 7:388-397, . (PMID: 24520038)

Bansal, N. Davis, S. Tereshchenko, I. Budak-Alpdogan, T. Zhong, H. Stein, M. N. Kim, I. Y. Dipaola, R. S. Bertino, J. R. Sabaawy, H. E. Enrichment of human prostate cancer cells with tumor initiating properties in mouse and zebrafish xenografts by differential adhesion. Prostate, 74:187-200, . (PMID: 24154958, PMCID: PMC3939797)

Wang, H. Cui, X. X. Goodin, S. Ding, N. Van Doren, J. Du, Z. Huang, M. T. Liu, Y. Cheng, X. Dipaola, R. S. Conney, A. H. Zheng, X. Inhibition of IL-6 expression in LNCaP prostate cancer cells by a combination of atorvastatin and celecoxib. Oncol Rep, 31:835-841, . (PMID: 24296978, PMCID: PMC3981114)

Padmanabhan, R. K. Somasundar, V. H. Griffith, S. D. Zhu, J. Samoyedny, D. Tan, K. S. Hu, J. Liao, X. Carin, L. Yoon, S. S. Flaherty, K. T. Dipaola, R. S. Heitjan, D. F. Lal, P. Feldman, M. D. Roysam, B. Lee, W. M. An active learning approach for rapid characterization of endothelial cells in human tumors. PLoS One, 9:e90495, . (PMID: 24603893, PMCID: PMC3946171)

Glod, J. Song, M. Sharma, A. Tyagi, R. Rhodes, R. H. Weissmann, D. J. Roychowdhury, S. Khan, A. Kane, M. P. Hirshfield, K. Ganesan, S. DiPaola, R. S. Rodriguez-Rodriguez, L. Next generation sequencing as an aid to diagnosis and treatment of an unusual pediatric brain cancer. J Pers Med, 4:402-411, . (PMID: 25563358)

Singer, E. A. Dipaola, R. S. Our shifting understanding of factors influencing prostate-specific antigen. J Natl Cancer Inst, 105:1264-1265, . (PMID: 23943863, PMCID: PMC3760781)

Guo, J. Y. Karsli-Uzunbas, G. Mathew, R. Aisner, S. C. Kamphorst, J. J. Strohecker, A. M. Chen, G. Price, S. Lu, W. Teng, X. Snyder, E. Santanam, U. Dipaola, R. S. Jacks, T. Rabinowitz, J. D. White, E. Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes Dev, 27:1447-1461, . (PMID: 23824538, PMCID: PMC3713426)

Goodin, S. Dipaola, R. S. Cabozantinib in Prostate Cancer: The Beginning of a Precision Paradigm? J Clin Oncol, 31:401-403, . (PMID: 23248244)

Raez, L. E. Papadopoulos, K. Ricart, A. D. Chiorean, E. G. Dipaola, R. S. Stein, M. N. Rocha Lima, C. M. Schlesselman, J. J. Tolba, K. Langmuir, V. K. Kroll, S. Jung, D. T. Kurtoglu, M. Rosenblatt, J. Lampidis, T. J. A phase I dose-escalation trial of 2-deoxy-D-glucose alone or combined with docetaxel in patients with advanced solid tumors. Cancer Chemother Pharmacol, 71:523-530, . (PMID: 23228990)

Ha, Y. S. Goodin, S. Dipaola, R. S. Kim, I. Y. Enzalutamide for the treatment of castration-resistant prostate cancer. Drugs Today (Barc), 49:7-13, . (PMID: 23362491)

Kang, W. DiPaola, R. S. Vazquez, A. Inference of synergy/antagonism between anticancer drugs from the pooled analysis of clinical trials. BMC Med Res Methodol, 13:77, . (PMID: 23758906, PMCID: PMC3694030)

Tedeschi, P. M. Markert, E. K. Gounder, M. Lin, H. Dvorzhinski, D. Dolfi, S. C. Chan, L. L. Qiu, J. Dipaola, R. S. Hirshfield, K. M. Boros, L. G. Bertino, J. R. Oltvai, Z. N. Vazquez, A. Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells. Cell Death Dis, 4:e877, . (PMID: 24157871, PMCID: PMC3920946)

Lu-Yao, G. L. Albertsen, P. C. Li, H. Moore, D. F. Shih, W. Lin, Y. Dipaola, R. S. Yao, S. L. Does Primary Androgen-Deprivation Therapy Delay the Receipt of Secondary Cancer Therapy for Localized Prostate Cancer? Eur Urol, 62:966-972, . (PMID: 22608160, PMCID: PMC3472155)

Hudson, S. V. Miller, S. M. Hemler, J. Ferrante, J. M. Lyle, J. Oeffinger, K. C. Dipaola, R. S. Adult cancer survivors discuss follow-up in primary care: 'not what i want, but maybe what i need'. Ann Fam Med, 10:418-427, . (PMID: 22966105, PMCID: PMC3438209)

Saleem, A. Dvorzhinski, D. Santanam, U. Mathew, R. Bray, K. Stein, M. White, E. Dipaola, R. S. Effect of dual inhibition of apoptosis and autophagy in prostate cancer. Prostate, 72:1374-1381, . (PMID: 22241682)

Lin, H. Gounder, M. K. Bertino, J. R. Kong, A. N. DiPaola, R. S. Stein, M. N. A validated HPLC assay for the determination of R-(-)-gossypol in human plasma and its application in clinical pharmacokinetic studies. J Pharm Biomed Anal, 66:371-375, . (PMID: 22483642, PMCID: PMC3358459)

Holen, K. Dipaola, R. Liu, G. Tan, A. R. Wilding, G. Hsu, K. Agrawal, N. Chen, C. Xue, L. Rosenberg, E. Stein, M. A phase I trial of MK-0731, a Kinesin Spindle Protein (KSP) inhibitor, in patients with solid tumors. Invest New Drugs, 30:1088-1095, . (PMID: 21424701, PMCID: PMC3394096)

Liu, G. Chen, Y. H. Dipaola, R. Carducci, M. Wilding, G. Phase II trial of weekly ixabepilone in men with metastatic castrate-resistant prostate cancer (E3803): a trial of the Eastern Cooperative Oncology Group. Clin Genitourin Cancer, 10:99-105, . (PMID: 22386239)

Gounder, M. K. Lin, H. Stein, M. Goodin, S. Bertino, J. R. Kong, A. N. DiPaola, R. S. A validated bioanalytical HPLC method for pharmacokinetic evaluation of 2-deoxyglucose in human plasma. Biomed Chromatogr, 26:650-654, . (PMID: 21932382)

Stein, M. Goodin, S. Doyle-Lindrud, S. Silberberg, J. Kane, M. Metzger, D. Eddy, S. Shih, W. DiPaola, R. S. Transdermal estradiol in castrate and chemotherapy resistant prostate cancer. Med Sci Monit, 18:CR260-CR264, . (PMID: 22460098)

Stein, M. N. Goodin, S. Dipaola, R. S. Abiraterone in prostate cancer: a new angle to an old problem. Clin Cancer Res, 18:1848-1854, . (PMID: 22451619)

Alva, A. Slovin, S. Daignault, S. Carducci, M. Dipaola, R. Pienta, K. Agus, D. Cooney, K. Chen, A. Smith, D. C. Hussain, M. Phase II study of cilengitide (EMD 121974, NSC 707544) in patients with non-metastatic castration resistant prostate cancer, NCI-6735. A study by the DOD/PCF prostate cancer clinical trials consortium. Invest New Drugs, 30:749-757, . (PMID: 21049281, PMCID: PMC3175265)

Bray, K. Mathew, R. Lau, A. Kamphorst, J. J. Fan, J. Chen, J. Chen, H. Y. Ghavami, A. Stein, M. Dipaola, R. S. Zhang, D. Rabinowitz, J. D. White, E. Autophagy Suppresses RIP Kinase-Dependent Necrosis Enabling Survival to mTOR Inhibition. PLoS One, 7:e41831, . (PMID: 22848625, PMCID: PMC3406086)

Bradley, D. A. Daignault, S. Ryan, C. J. Dipaola, R. S. Smith, D. C. Small, E. Gross, M. E. Stein, M. N. Chen, A. Hussain, M. Cilengitide (EMD 121974, NSC 707544) in asymptomatic metastatic castration resistant prostate cancer patients: a randomized phase II trial by the prostate cancer clinical trials consortium. Invest New Drugs, 29:1432-1440, . (PMID: 20336348, PMCID: PMC2917503)

Liu, G. Chen, Y. H. Kolesar, J. Huang, W. Dipaola, R. Pins, M. Carducci, M. Stein, M. Bubley, G. J. Wilding, G. Eastern Cooperative Oncology Group Phase II Trial of lapatinib in men with biochemically relapsed, androgen dependent prostate cancer(,). Urol Oncol, In process, . (PMID: 21784672, PMCID: PMC3223557)

Guo, J. Y. Chen, H. Y. Mathew, R. Fan, J. Strohecker, A. M. Karsli-Uzunbas, G. Kamphorst, J. J. Chen, G. Lemons, J. M. Karantza, V. Coller, H. A. Dipaola, R. S. Gelinas, C. Rabinowitz, J. D. White, E. Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev, 25:460-470, . (PMID: 21317241, PMCID: PMC3049287)

Amaravadi, R. K. Lippincott-Schwartz, J. Yin, X. M. Weiss, W. A. Takebe, N. Timmer, W. DiPaola, R. S. Lotze, M. T. White, E. Principles and current strategies for targeting autophagy for cancer treatment. Clin Cancer Res, 17:654-666, . (PMID: 21325294, PMCID: PMC3075808)

Delnevo, C. D. Steinberg, M. B. Hudson, S. V. Ulpe, R. Dipaola, R. S. Epidemiology of Cigarette and Smokeless Tobacco Use among South Asian Immigrants in the Northeastern United States. J Oncol, 2011:252675, . (PMID: 21772842, PMCID: PMC3136136)

Zheng, X. Cui, X. X. Khor, T. O. Huang, Y. Dipaola, R. S. Goodin, S. Lee, M. J. Yang, C. S. Kong, A. N. Conney, A. H. Inhibitory Effect of a gamma-Tocopherol-Rich Mixture of Tocopherols on the Formation and Growth of LNCaP Prostate Tumors in Immunodeficient Mice. Cancers (Basel), 3:3762-3772, . (PMID: 24213110, PMCID: PMC3763395)