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Robert S. DiPaola, MD

Publications since 2011

Lu-Yao, G. L. Kim, S. Moore, D. F. Shih, W. Lin, Y. DiPaola, R. S. Shen, S. Zietman, A. Yao, S. L. Primary radiotherapy vs conservative management for localized prostate cancer-a population-based study. Prostate Cancer Prostatic Dis, In process, . (PMID: 26101187)

Flaherty, K. T. Manola, J. B. Pins, M. McDermott, D. F. Atkins, M. B. Dutcher, J. J. George, D. J. Margolin, K. A. DiPaola, R. S. BEST: A Randomized Phase II Study of Vascular Endothelial Growth Factor, RAF Kinase, and Mammalian Target of Rapamycin Combination Targeted Therapy With Bevacizumab, Sorafenib, and Temsirolimus in Advanced Renal Cell Carcinoma-A Trial of the ECOG-ACRIN Cancer Research Group (E2804). J Clin Oncol, In process, . (PMID: 26077237)

Bansal, N. Mishra, P. J. Stein, M. DiPaola, R. S. Bertino, J. R. Axl receptor tyrosine kinase is up-regulated in metformin resistant prostate cancer cells. Oncotarget, In process, . (PMID: 26036314)

Haas, N. Manola, J. Ky, B. Flaherty, K. T. Uzzo, R. G. Kane, C. Jewett, M. A. Wood, L. Wood, C. G. Atkins, M. B. Dutcher, J. P. Wilding, G. DiPaola, R. Effects of adjuvant sorafenib and sunitinib on cardiac function in renal cell carcinoma patients without overt metastases:results from ASSURE, ECOG2805. Clin Cancer Res, In process, . (PMID: 25967143)

Yue, W. Zheng, X. Lin, Y. Yang, C. S. Xu, Q. Carpizo, D. Huang, H. DiPaola, R. S. Tan, X. L. Metformin combined with aspirin significantly inhibit pancreatic cancer cell growth in vitro and in vivo by suppressing anti-apoptotic proteins Mcl-1 and Bcl-2. Oncotarget, In process, . (PMID: 26056043)

Lu-Yao, G. L. Albertsen, P. C. Moore, D. F. Lin, Y. DiPaola, R. S. Yao, S. L. Fifteen-year Outcomes Following Conservative Management Among Men Aged 65 Years or Older with Localized Prostate Cancer. Eur Urol, In process, . (PMID: 25800944)

Hussain, M. DiPaola, R. S. Clinical research in metastatic prostate cancer: a focus on impact and value. Am Soc Clin Oncol Educ Book, 35:17-21, . (PMID: 25993136)

DiPaola, R. S. Chen, Y. Bubley, G. J. Stein, M. N. Hahn, N. M. Carducci, M. A. Lattime, E. C. Gulley, J. L. Arlen, P. M. Butterfield, L. H. Wilding, G. A National Multicenter Phase 2 Study of Prostate-specific Antigen (PSA) Pox Virus Vaccine with Sequential Androgen Ablation Therapy in Patients with PSA Progression: ECOG 9802. Eur Urol, In process, . (PMID: 25533418)

Tereshchenko, I. V. Zhong, H. Chekmareva, M. A. Kane-Goldsmith, N. Santanam, U. Petrosky, W. Stein, M. N. Ganesan, S. Singer, E. A. Moore, D. Tischfield, J. A. DiPaola, R. S. ERG and CHD1 heterogeneity in prostate cancer: Use of confocal microscopy in assessment of microscopic foci. Prostate, 74:1551-1559, . (PMID: 25175909, PMCID: PMC4181586)

Song, M. DiPaola, R. S. Cracchiolo, B. M. Gibbon, D. G. Hellmann, M. Nieves-Neira, W. Vaidya, A. Wagreich, A. R. Shih, W. J. Rodriguez-Rodriguez, L. Phase 2 Trial of Paclitaxel, 13-cis Retinoic Acid, and Interferon Alfa-2b in the Treatment of Advanced Stage or Recurrent Cervical Cancer. Int J Gynecol Cancer, 24:1636-1641, . (PMID: 25304678, PMCID: PMC4211961)

Lu-Yao, G. L. Albertsen, P. C. Moore, D. F. Shih, W. Lin, Y. DiPaola, R. S. Yao, S. L. Fifteen-Year Survival Outcomes Following Primary Androgen-Deprivation Therapy for Localized Prostate Cancer. JAMA Intern Med, 174:1460-1467, . (PMID: 25023796)

Richie, J. P. Das, A. Calcagnotto, A. Sinha, R. Neidig, W. Liao, J. Lengerich, E. J. Berg, A. Hartman, T. J. Ciccarella, A. Baker, A. Kaag, M. G. Goodin, S. DiPaola, R. S. El-Bayoumy, K. Comparative effects of two different forms of selenium on oxidative stress biomarkers in healthy men: a randomized clinical trial. Cancer Prev Res (Phila), 7:796-804, . (PMID: 24938534, PMCID: PMC4125492)

Huang, H. Cui, X. X. Chen, S. Goodin, S. Liu, Y. He, Y. Li, D. Wang, H. VAN Doren, J. Dipaola, R. S. Conney, A. H. Zheng, X. Combination of Lipitor and Celebrex Inhibits Prostate Cancer VCaP Cells In Vitro and In Vivo. Anticancer Res, 34:3357-3363, . (PMID: 24982340)

Pillai, R. N. Aisner, J. Dahlberg, S. E. Rogers, J. S. DiPaola, R. S. Aisner, S. Ramalingam, S. S. Schiller, J. H. Interferon alpha plus 13-cis-retinoic acid modulation of BCL-2 plus paclitaxel for recurrent small-cell lung cancer (SCLC): an Eastern Cooperative Oncology Group study (E6501). Cancer Chemother Pharmacol, 74:177-183, . (PMID: 24858462)

Yue, W. Yang, C. S. Dipaola, R. S. Tan, X. L. Repurposing of metformin and aspirin by targeting AMPK-mTOR and inflammation for pancreatic cancer prevention and treatment. Cancer Prev Res (Phila), 7:388-397, . (PMID: 24520038)

Bansal, N. Davis, S. Tereshchenko, I. Budak-Alpdogan, T. Zhong, H. Stein, M. N. Kim, I. Y. Dipaola, R. S. Bertino, J. R. Sabaawy, H. E. Enrichment of human prostate cancer cells with tumor initiating properties in mouse and zebrafish xenografts by differential adhesion. Prostate, 74:187-200, . (PMID: 24154958, PMCID: PMC3939797)

Wang, H. Cui, X. X. Goodin, S. Ding, N. Van Doren, J. Du, Z. Huang, M. T. Liu, Y. Cheng, X. Dipaola, R. S. Conney, A. H. Zheng, X. Inhibition of IL-6 expression in LNCaP prostate cancer cells by a combination of atorvastatin and celecoxib. Oncol Rep, 31:835-841, . (PMID: 24296978, PMCID: PMC3981114)

Padmanabhan, R. K. Somasundar, V. H. Griffith, S. D. Zhu, J. Samoyedny, D. Tan, K. S. Hu, J. Liao, X. Carin, L. Yoon, S. S. Flaherty, K. T. Dipaola, R. S. Heitjan, D. F. Lal, P. Feldman, M. D. Roysam, B. Lee, W. M. An active learning approach for rapid characterization of endothelial cells in human tumors. PLoS One, 9:e90495, . (PMID: 24603893, PMCID: PMC3946171)

Glod, J. Song, M. Sharma, A. Tyagi, R. Rhodes, R. H. Weissmann, D. J. Roychowdhury, S. Khan, A. Kane, M. P. Hirshfield, K. Ganesan, S. DiPaola, R. S. Rodriguez-Rodriguez, L. Next generation sequencing as an aid to diagnosis and treatment of an unusual pediatric brain cancer. J Pers Med, 4:402-411, . (PMID: 25563358)

Singer, E. A. Dipaola, R. S. Our shifting understanding of factors influencing prostate-specific antigen. J Natl Cancer Inst, 105:1264-1265, . (PMID: 23943863, PMCID: PMC3760781)

Guo, J. Y. Karsli-Uzunbas, G. Mathew, R. Aisner, S. C. Kamphorst, J. J. Strohecker, A. M. Chen, G. Price, S. Lu, W. Teng, X. Snyder, E. Santanam, U. Dipaola, R. S. Jacks, T. Rabinowitz, J. D. White, E. Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes Dev, 27:1447-1461, . (PMID: 23824538, PMCID: PMC3713426)

Goodin, S. Dipaola, R. S. Cabozantinib in Prostate Cancer: The Beginning of a Precision Paradigm? J Clin Oncol, 31:401-403, . (PMID: 23248244)

Raez, L. E. Papadopoulos, K. Ricart, A. D. Chiorean, E. G. Dipaola, R. S. Stein, M. N. Rocha Lima, C. M. Schlesselman, J. J. Tolba, K. Langmuir, V. K. Kroll, S. Jung, D. T. Kurtoglu, M. Rosenblatt, J. Lampidis, T. J. A phase I dose-escalation trial of 2-deoxy-D-glucose alone or combined with docetaxel in patients with advanced solid tumors. Cancer Chemother Pharmacol, 71:523-530, . (PMID: 23228990)

Ha, Y. S. Goodin, S. Dipaola, R. S. Kim, I. Y. Enzalutamide for the treatment of castration-resistant prostate cancer. Drugs Today (Barc), 49:7-13, . (PMID: 23362491)

Kang, W. DiPaola, R. S. Vazquez, A. Inference of synergy/antagonism between anticancer drugs from the pooled analysis of clinical trials. BMC Med Res Methodol, 13:77, . (PMID: 23758906, PMCID: PMC3694030)

Tedeschi, P. M. Markert, E. K. Gounder, M. Lin, H. Dvorzhinski, D. Dolfi, S. C. Chan, L. L. Qiu, J. Dipaola, R. S. Hirshfield, K. M. Boros, L. G. Bertino, J. R. Oltvai, Z. N. Vazquez, A. Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells. Cell Death Dis, 4:e877, . (PMID: 24157871, PMCID: PMC3920946)

Lu-Yao, G. L. Albertsen, P. C. Li, H. Moore, D. F. Shih, W. Lin, Y. Dipaola, R. S. Yao, S. L. Does Primary Androgen-Deprivation Therapy Delay the Receipt of Secondary Cancer Therapy for Localized Prostate Cancer? Eur Urol, 62:966-972, . (PMID: 22608160, PMCID: PMC3472155)

Hudson, S. V. Miller, S. M. Hemler, J. Ferrante, J. M. Lyle, J. Oeffinger, K. C. Dipaola, R. S. Adult cancer survivors discuss follow-up in primary care: 'not what i want, but maybe what i need'. Ann Fam Med, 10:418-427, . (PMID: 22966105, PMCID: PMC3438209)

Saleem, A. Dvorzhinski, D. Santanam, U. Mathew, R. Bray, K. Stein, M. White, E. Dipaola, R. S. Effect of dual inhibition of apoptosis and autophagy in prostate cancer. Prostate, 72:1374-1381, . (PMID: 22241682)

Lin, H. Gounder, M. K. Bertino, J. R. Kong, A. N. DiPaola, R. S. Stein, M. N. A validated HPLC assay for the determination of R-(-)-gossypol in human plasma and its application in clinical pharmacokinetic studies. J Pharm Biomed Anal, 66:371-375, . (PMID: 22483642, PMCID: PMC3358459)

Holen, K. Dipaola, R. Liu, G. Tan, A. R. Wilding, G. Hsu, K. Agrawal, N. Chen, C. Xue, L. Rosenberg, E. Stein, M. A phase I trial of MK-0731, a Kinesin Spindle Protein (KSP) inhibitor, in patients with solid tumors. Invest New Drugs, 30:1088-1095, . (PMID: 21424701, PMCID: PMC3394096)

Liu, G. Chen, Y. H. Dipaola, R. Carducci, M. Wilding, G. Phase II trial of weekly ixabepilone in men with metastatic castrate-resistant prostate cancer (E3803): a trial of the Eastern Cooperative Oncology Group. Clin Genitourin Cancer, 10:99-105, . (PMID: 22386239)

Gounder, M. K. Lin, H. Stein, M. Goodin, S. Bertino, J. R. Kong, A. N. DiPaola, R. S. A validated bioanalytical HPLC method for pharmacokinetic evaluation of 2-deoxyglucose in human plasma. Biomed Chromatogr, 26:650-654, . (PMID: 21932382)

Stein, M. Goodin, S. Doyle-Lindrud, S. Silberberg, J. Kane, M. Metzger, D. Eddy, S. Shih, W. DiPaola, R. S. Transdermal estradiol in castrate and chemotherapy resistant prostate cancer. Med Sci Monit, 18:CR260-CR264, . (PMID: 22460098)

Stein, M. N. Goodin, S. Dipaola, R. S. Abiraterone in prostate cancer: a new angle to an old problem. Clin Cancer Res, 18:1848-1854, . (PMID: 22451619)

Alva, A. Slovin, S. Daignault, S. Carducci, M. Dipaola, R. Pienta, K. Agus, D. Cooney, K. Chen, A. Smith, D. C. Hussain, M. Phase II study of cilengitide (EMD 121974, NSC 707544) in patients with non-metastatic castration resistant prostate cancer, NCI-6735. A study by the DOD/PCF prostate cancer clinical trials consortium. Invest New Drugs, 30:749-757, . (PMID: 21049281, PMCID: PMC3175265)

Bray, K. Mathew, R. Lau, A. Kamphorst, J. J. Fan, J. Chen, J. Chen, H. Y. Ghavami, A. Stein, M. Dipaola, R. S. Zhang, D. Rabinowitz, J. D. White, E. Autophagy Suppresses RIP Kinase-Dependent Necrosis Enabling Survival to mTOR Inhibition. PLoS One, 7:e41831, . (PMID: 22848625, PMCID: PMC3406086)

Bradley, D. A. Daignault, S. Ryan, C. J. Dipaola, R. S. Smith, D. C. Small, E. Gross, M. E. Stein, M. N. Chen, A. Hussain, M. Cilengitide (EMD 121974, NSC 707544) in asymptomatic metastatic castration resistant prostate cancer patients: a randomized phase II trial by the prostate cancer clinical trials consortium. Invest New Drugs, 29:1432-1440, . (PMID: 20336348, PMCID: PMC2917503)

Liu, G. Chen, Y. H. Kolesar, J. Huang, W. Dipaola, R. Pins, M. Carducci, M. Stein, M. Bubley, G. J. Wilding, G. Eastern Cooperative Oncology Group Phase II Trial of lapatinib in men with biochemically relapsed, androgen dependent prostate cancer(,). Urol Oncol, In process, . (PMID: 21784672, PMCID: PMC3223557)

Guo, J. Y. Chen, H. Y. Mathew, R. Fan, J. Strohecker, A. M. Karsli-Uzunbas, G. Kamphorst, J. J. Chen, G. Lemons, J. M. Karantza, V. Coller, H. A. Dipaola, R. S. Gelinas, C. Rabinowitz, J. D. White, E. Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev, 25:460-470, . (PMID: 21317241, PMCID: PMC3049287)

Amaravadi, R. K. Lippincott-Schwartz, J. Yin, X. M. Weiss, W. A. Takebe, N. Timmer, W. DiPaola, R. S. Lotze, M. T. White, E. Principles and current strategies for targeting autophagy for cancer treatment. Clin Cancer Res, 17:654-666, . (PMID: 21325294, PMCID: PMC3075808)

Delnevo, C. D. Steinberg, M. B. Hudson, S. V. Ulpe, R. Dipaola, R. S. Epidemiology of Cigarette and Smokeless Tobacco Use among South Asian Immigrants in the Northeastern United States. J Oncol, 2011:252675, . (PMID: 21772842, PMCID: PMC3136136)

Zheng, X. Cui, X. X. Khor, T. O. Huang, Y. Dipaola, R. S. Goodin, S. Lee, M. J. Yang, C. S. Kong, A. N. Conney, A. H. Inhibitory Effect of a gamma-Tocopherol-Rich Mixture of Tocopherols on the Formation and Growth of LNCaP Prostate Tumors in Immunodeficient Mice. Cancers (Basel), 3:3762-3772, . (PMID: 24213110, PMCID: PMC3763395)