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Edward Arnold, PhD

Publications since 2011

Goswami, D. Tuske, S. Pascal, B. D. Bauman, J. D. Patel, D. Arnold, E. Griffin, P. R. Differential Isotopic Enrichment To Facilitate Characterization of Asymmetric Multimeric Proteins Using Hydrogen/Deuterium Exchange Mass Spectrometry. Anal Chem, In process, . (PMID: 25763479)

Balzarini, J. Das, K. Bernatchez, J. A. Martinez, S. E. Ngure, M. Keane, S. Ford, A. Maguire, N. Mullins, N. John, J. Kim, Y. Dehaen, W. Vande Voorde, J. Liekens, S. Naesens, L. Gotte, M. Maguire, A. R. Arnold, E. Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics. Proc Natl Acad Sci U S A, In process, . (PMID: 25733891)

Sagong, H. Y. Bauman, J. D. Patel, D. Das, K. Arnold, E. LaVoie, E. J. Phenyl Substituted 4-Hydroxypyridazin-3(2H)-ones and 5-Hydroxypyrimidin-4(3H)-ones: Inhibitors of Influenza A Endonuclease. J Med Chem, 57:8086-8098, . (PMID: 25225968, PMCID: PMC4191602)

Singh, K. Flores, J. A. Kirby, K. A. Neogi, U. Sonnerborg, A. Hachiya, A. Das, K. Arnold, E. McArthur, C. Parniak, M. Sarafianos, S. G. Drug Resistance in Non-B Subtype HIV-1: Impact of HIV-1 Reverse Transcriptase Inhibitors. Viruses, 6:3535-3562, . (PMID: 25254383, PMCID: PMC4189038)

Himmel, D. M. Myshakina, N. S. Ilina, T. Van Ry, A. Ho, W. C. Parniak, M. A. Arnold, E. Structure of a Dihydroxycoumarin Active-Site Inhibitor in Complex with the RNase H Domain of HIV-1 Reverse Transcriptase and Structure-Activity Analysis of Inhibitor Analogs. J Mol Biol, 426:2617-2631, . (PMID: 24840303, PMCID: PMC4116331)

Abram, M. E. Ferris, A. L. Das, K. Quinones, O. Shao, W. Tuske, S. Alvord, W. G. Arnold, E. Hughes, S. H. Mutations in HIV-1 Reverse Transcriptase Affect the Errors Made in a Single Cycle of Viral Replication. J Virol, 88:7589-7601, . (PMID: 24760888, PMCID: PMC4054409)

Vijayan, R. S. Arnold, E. Das, K. Molecular dynamics study of HIV-1 RT-DNA-nevirapine complexes explains NNRTI inhibition and resistance by connection mutations. Proteins, 82:815-829, . (PMID: 24174331)

Zhang, Y. Degen, D. Ho, M. X. Sineva, E. Ebright, K. Y. Ebright, Y. W. Mekler, V. Vahedian-Movahed, H. Feng, Y. Yin, R. Tuske, S. Irschik, H. Jansen, R. Maffioli, S. Donadio, S. Arnold, E. Ebright, R. H. GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides. Elife, 3:e02450, . (PMID: 24755292, PMCID: PMC3994528)

Degen, D. Feng, Y. Zhang, Y. Ebright, K. Y. Ebright, Y. W. Gigliotti, M. Vahedian-Movahed, H. Mandal, S. Talaue, M. Connell, N. Arnold, E. Fenical, W. Ebright, R. H. Transcription inhibition by the depsipeptide antibiotic salinamide A. Elife, 3:e02451, . (PMID: 24843001, PMCID: PMC4029172)

Das, K. Martinez, S. E. Bandwar, R. P. Arnold, E. Structures of HIV-1 RT-RNA/DNA ternary complexes with dATP and nevirapine reveal conformational flexibility of RNA/DNA: insights into requirements for RNase H cleavage. Nucleic Acids Res, 42:8125-8137, . (PMID: 24880687, PMCID: PMC4081091)

Patel, D. Bauman, J. D. Arnold, E. Advantages of crystallographic fragment screening: Functional and mechanistic insights from a powerful platform for efficient drug discovery. Prog Biophys Mol Biol, 116:92-100, . (PMID: 25117499)

Arnold, E. Fragment Screening for Drug Discovery: Efficient Approaches for Exploring Chemical Space. Prog Biophys Mol Biol, 116:81, . (PMID: 25433582)

Das, K. Sarafianos, S. G. Arnold, E. Structural requirements for RNA degradation by HIV-1 reverse transcriptase. Nat Struct Mol Biol, 20:1341-1342, . (PMID: 24304910)

Bauman, J. D. Patel, D. Baker, S. F. Vijayan, R. S. Xiang, A. Parhi, A. K. Martinez-Sobrido, L. Lavoie, E. J. Das, K. Arnold, E. Crystallographic Fragment Screening and Structure-Based Optimization Yields a New Class of Influenza Endonuclease Inhibitors. ACS Chem Biol, 8:2501-2508, . (PMID: 23978130, PMCID: PMC3928712)

Parhi, A. K. Xiang, A. Bauman, J. D. Patel, D. Vijayan, R. S. Das, K. Arnold, E. Lavoie, E. J. Phenyl substituted 3-hydroxypyridin-2(1H)-ones: Inhibitors of influenza A endonuclease. Bioorg Med Chem, 21:6435-6446, . (PMID: 24055080)

Kaul, M. Zhang, Y. Parhi, A. K. Lavoie, E. J. Tuske, S. Arnold, E. Kerrigan, J. E. Pilch, D. S. Enterococcal and streptococcal resistance to PC190723 and related compounds: Molecular insights from a FtsZ mutational analysis. Biochimie, 95:1880-1887, . (PMID: 23806423)

Bollini, M. Frey, K. M. Cisneros, J. A. Spasov, K. A. Das, K. Bauman, J. D. Arnold, E. Anderson, K. S. Jorgensen, W. L. Extension into the entrance channel of HIV-1 reverse transcriptase-Crystallography and enhanced solubility. Bioorg Med Chem Lett, 23:5209-5212, . (PMID: 23899617, PMCID: PMC3761378)

Sagong, H. Y. Parhi, A. Bauman, J. D. Patel, D. Vijayan, R. S. Das, K. Arnold, E. LaVoie, E. J. 3-Hydroxyquinolin-2(1H)-ones As Inhibitors of Influenza A Endonuclease. ACS Med Chem Lett, 4:547-550, . (PMID: 24936242, PMCID: PMC4056971)

Bauman, J. D. Patel, D. Dharia, C. Fromer, M. Ahmed, S. Frenkel, Y. Eck, J. T. Ho, W. Das, K. Shatkin, A. Arnold, E. Detecting allosteric sites of HIV-1 reverse transcriptase by X-ray crystallographic fragment screening. J Med Chem, 56:2738-2746, . (PMID: 23342998)

Das, K. Arnold, E. HIV-1 reverse transcriptase and antiviral drug resistance. Part 1. Curr Opin Virol, 3:111-118, . (PMID: 23602471)

Das, K. Arnold, E. HIV-1 reverse transcriptase and antiviral drug resistance. Part 2. Curr Opin Virol, 3:119-128, . (PMID: 23602470)

Kuroda, D. G. Bauman, J. D. Challa, J. R. Patel, D. Troxler, T. Das, K. Arnold, E. Hochstrasser, R. M. Snapshot of the equilibrium dynamics of a drug bound to HIV-1 reverse transcriptase. Nat Chem, 5:174-181, . (PMID: 23422558, PMCID: PMC3607437)

Yi, G. Lapelosa, M. Bradley, R. Mariano, T. M. Dietz, D. E. Hughes, S. Wrin, T. Petropoulos, C. Gallicchio, E. Levy, R. M. Arnold, E. Arnold, G. F. Chimeric Rhinoviruses Displaying MPER Epitopes Elicit Anti-HIV Neutralizing Responses. PLoS One, 8:e72205, . (PMID: 24039745, PMCID: PMC3765159)

Kaul, M. Parhi, A. K. Zhang, Y. Lavoie, E. J. Tuske, S. Arnold, E. Kerrigan, J. E. Pilch, D. S. A Bactericidal Guanidinomethyl Biaryl That Alters the Dynamics of Bacterial FtsZ Polymerization. J Med Chem, 55:10160-10176, . (PMID: 23050700)

Zhang, Y. Feng, Y. Chatterjee, S. Tuske, S. Ho, M. X. Arnold, E. Ebright, R. H. Structural Basis of Transcription Initiation. Science, 338:1076-1080, . (PMID: 23086998, PMCID: PMC3593053)

Das, K. Martinez, S. E. Bauman, J. D. Arnold, E. HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism. Nat Struct Mol Biol, 19:253-259, . (PMID: 22266819, PMCID: PMC3359132)

Bauman, J. D. Patel, D. Arnold, E. Fragment screening and HIV therapeutics. Top Curr Chem, 317:181-200, . (PMID: 21972022)

Felts, A. K. Labarge, K. Bauman, J. D. Patel, D. V. Himmel, D. M. Arnold, E. Parniak, M. A. Levy, R. M. Identification of alternative binding sites for inhibitors of HIV-1 ribonuclease H through comparative analysis of virtual enrichment studies. J Chem Inf Model, 51:1986-1998, . (PMID: 21714567, PMCID: PMC3159817)

Chung, S. Himmel, D. M. Jiang, J. K. Wojtak, K. Bauman, J. D. Rausch, J. W. Wilson, J. A. Beutler, J. A. Thomas, C. J. Arnold, E. Le Grice, S. F. Synthesis, activity, and structural analysis of novel alpha-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H. J Med Chem, 54:4462-4473, . (PMID: 21568335, PMCID: PMC3133734)

Chu, C. Das, K. Tyminski, J. R. Bauman, J. D. Guan, R. Qiu, W. Montelione, G. T. Arnold, E. Shatkin, A. J. Structure of the guanylyltransferase domain of human mRNA capping enzyme. Proc Natl Acad Sci U S A, 108:10104-10108, . (PMID: 21636784, PMCID: PMC3121809)

Das, K. Bauman, J. D. Rim, A. S. Dharia, C. Clark, A. D. Jr Camarasa, M. J. Balzarini, J. Arnold, E. Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. J Med Chem, 54:2727-2737, . (PMID: 21446702, PMCID: PMC3361896)