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Joshua D. Rabinowitz, MD, PhD

Publications since 2011

Purdy, J. G. Shenk, T. Rabinowitz, J. D. Fatty Acid elongase 7 catalyzes lipidome remodeling essential for human cytomegalovirus replication. Cell Rep, 10:1375-1385, . (PMID: 25732827)

Buescher, J. M. Antoniewicz, M. R. Boros, L. G. Burgess, S. C. Brunengraber, H. Clish, C. B. DeBerardinis, R. J. Feron, O. Frezza, C. Ghesquiere, B. Gottlieb, E. Hiller, K. Jones, R. G. Kamphorst, J. J. Kibbey, R. G. Kimmelman, A. C. Locasale, J. W. Lunt, S. Y. Maddocks, O. D. Malloy, C. Metallo, C. M. Meuillet, E. J. Munger, J. Noh, K. Rabinowitz, J. D. Ralser, M. Sauer, U. Stephanopoulos, G. St-Pierre, J. Tennant, D. A. Wittmann, C. Vander Heiden, M. G. Vazquez, A. Vousden, K. Young, J. D. Zamboni, N. Fendt, S. M. A roadmap for interpreting C metabolite labeling patterns from cells. Curr Opin Biotechnol, In process, . (PMID: 25731751)

Kamphorst, J. J. Nofal, M. Commisso, C. Hackett, S. R. Lu, W. Grabocka, E. Vander Heiden, M. G. Miller, G. Drebin, J. A. Bar-Sagi, D. Thompson, C. B. Rabinowitz, J. D. Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein. Cancer Res, 75:544-553, . (PMID: 25644265, PMCID: PMC4316379)

Ducker, G. S. Rabinowitz, J. D. ZMP: A Master Regulator of One-Carbon Metabolism. Mol Cell, 57:203-204, . (PMID: 25616065)

Aristilde, L. Lewis, I. A. Park, J. O. Rabinowitz, J. D. Hierarchy in Pentose Sugar Metabolism in Clostridium Acetobutylicum. Appl Environ Microbiol, In process, . (PMID: 25527534)

Hwang, J. Purdy, J. G. Wu, K. Rabinowitz, J. D. Shenk, T. Estrogen-related receptor alpha is required for efficient human cytomegalovirus replication. Proc Natl Acad Sci U S A, In process, . (PMID: 25512541)

Fan, J. Teng, X. Liu, L. Mattaini, K. R. Looper, R. E. Vander Heiden, M. G. Rabinowitz, J. D. Human Phosphoglycerate Dehydrogenase Produces the Oncometabolite d-2-Hydroxyglutarate. ACS Chem Biol, In process, . (PMID: 25406093)

Zhang, J. Fan, J. Venneti, S. Cross, J. R. Takagi, T. Bhinder, B. Djaballah, H. Kanai, M. Cheng, E. H. Judkins, A. R. Pawel, B. Baggs, J. Cherry, S. Rabinowitz, J. D. Thompson, C. B. Asparagine Plays a Critical Role in Regulating Cellular Adaptation to Glutamine Depletion. Mol Cell, 56:205-218, . (PMID: 25242145, PMCID: PMC4224619)

Castellana, M. Wilson, M. Z. Xu, Y. Joshi, P. Cristea, I. M. Rabinowitz, J. D. Gitai, Z. Wingreen, N. S. Enzyme clustering accelerates processing of intermediates through metabolic channeling. Nat Biotechnol, 32:1011-1018, . (PMID: 25262299)

Stincone, A. Prigione, A. Cramer, T. Wamelink, M. M. Campbell, K. Cheung, E. Olin-Sandoval, V. Gruening, N. M. Krueger, A. Tauqeer Alam, M. Keller, M. A. Breitenbach, M. Brindle, K. M. Rabinowitz, J. D. Ralser, M. The return of metabolism: biochemistry and physiology of the pentose phosphate pathway. Biol Rev Camb Philos Soc, In process, . (PMID: 25243985)

Mathew, R. Khor, S. Hackett, S. R. Rabinowitz, J. D. Perlman, D. H. White, E. Functional Role of Autophagy-Mediated Proteome Remodeling in Cell Survival Signaling and Innate Immunity. Mol Cell, 55:916-930, . (PMID: 25175026, PMCID: PMC4169768)

Ye, J. Fan, J. Venneti, S. Wan, Y. W. Pawel, B. R. Zhang, J. Finley, L. W. Lu, C. Lindsten, T. Cross, J. Qing, G. Liu, Z. Simon, M. C. Rabinowitz, J. D. Thompson, C. B. Serine catabolism regulates mitochondrial redox control during hypoxia. Cancer Discov, In process, . (PMID: 25186948)

Karsli-Uzunbas, G. Guo, J. Y. Price, S. M. Teng, X. Laddha, S. V. Khor, S. Kalaany, N. Y. Jacks, T. Chan, C. S. Rabinowitz, J. D. White, E. Autophagy is Required for Glucose Homeostasis and Lung Tumor Maintenance. Cancer Discov, 4:914-927, . (PMID: 24875857, PMCID: PMC4125614)

Fan, J. Ye, J. Kamphorst, J. J. Shlomi, T. Thompson, C. B. Rabinowitz, J. D. Quantitative flux analysis reveals folate-dependent NADPH production. Nature, 510:298-302, . (PMID: 24805240, PMCID: PMC4104482)

Breunig, J. S. Hackett, S. R. Rabinowitz, J. D. Kruglyak, L. Genetic basis of metabolome variation in yeast. PLoS Genet, 10:e1004142, . (PMID: 24603560, PMCID: PMC3945093)

Shlomi, T. Fan, J. Tang, B. Kruger, W. D. Rabinowitz, J. D. Quantitation of cellular metabolic fluxes of methionine. Anal Chem, 86:1583-1591, . (PMID: 24397525, PMCID: PMC4060246)

Kamphorst, J. J. Chung, M. K. Fan, J. Rabinowitz, J. D. Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate. Cancer Metab, 2:23, . (PMID: 25671109, PMCID: PMC4322440)

Kliegman, J. I. Fiedler, D. Ryan, C. J. Xu, Y. F. Su, X. Y. Thomas, D. Caccese, M. C. Cheng, A. Shales, M. Rabinowitz, J. D. Krogan, N. J. Shokat, K. M. Chemical Genetics of Rapamycin-Insensitive TORC2 in S. cerevisiae. Cell Rep, 5:1725-1736, . (PMID: 24360963, PMCID: PMC4007695)

Grady, S. L. Purdy, J. G. Rabinowitz, J. D. Shenk, T. Argininosuccinate synthetase 1 depletion produces a metabolic state conducive to herpes simplex virus 1 infection. Proc Natl Acad Sci U S A, 110:E5006-E5015, . (PMID: 24297925, PMCID: PMC3870743)

Tchigvintsev, A. Tchigvintsev, D. Flick, R. Popovic, A. Dong, A. Xu, X. Brown, G. Lu, W. Wu, H. Cui, H. Dombrowski, L. Joo, J. C. Beloglazova, N. Min, J. Savchenko, A. Caudy, A. A. Rabinowitz, J. D. Murzin, A. G. Yakunin, A. F. Biochemical and structural studies of conserved Maf proteins revealed nucleotide pyrophosphatases with a preference for modified nucleotides. Chem Biol, 20:1386-1398, . (PMID: 24210219, PMCID: PMC3899018)

Fan, J. Kamphorst, J. J. Rabinowitz, J. D. Shlomi, T. Fatty acid labeling from glutamine in hypoxia can be explained by isotope exchange without net reductive IDH flux. J Biol Chem, 288:31363-31369, . (PMID: 24030823, PMCID: PMC3829450)

Rabinowitz, J. D. Silhavy, T. J. Systems biology: metabolite turns master regulator. Nature, 500:283-284, . (PMID: 23925111)

Reaves, M. L. Young, B. D. Hosios, A. M. Xu, Y. F. Rabinowitz, J. D. Pyrimidine homeostasis is accomplished by directed overflow metabolism. Nature, 500:237-241, . (PMID: 23903661)

Guo, J. Y. Karsli-Uzunbas, G. Mathew, R. Aisner, S. C. Kamphorst, J. J. Strohecker, A. M. Chen, G. Price, S. Lu, W. Teng, X. Snyder, E. Santanam, U. Dipaola, R. S. Jacks, T. Rabinowitz, J. D. White, E. Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes Dev, 27:1447-1461, . (PMID: 23824538, PMCID: PMC3713426)

Commisso, C. Davidson, S. M. Soydaner-Azeloglu, R. G. Parker, S. J. Kamphorst, J. J. Hackett, S. Grabocka, E. Nofal, M. Drebin, J. A. Thompson, C. B. Rabinowitz, J. D. Metallo, C. M. Vander Heiden, M. G. Bar-Sagi, D. Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature, 497:633-637, . (PMID: 23665962)

Olszewski, K. L. Mather, M. W. Morrisey, J. M. Garcia, B. A. Vaidya, A. B. Rabinowitz, J. D. Llinas, M. Retraction: Branched tricarboxylic acid metabolism in Plasmodium falciparum. Nature, 497:652, . (PMID: 23615611)

Kamphorst, J. J. Cross, J. R. Fan, J. de Stanchina, E. Mathew, R. White, E. P. Thompson, C. B. Rabinowitz, J. D. Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids. Proc Natl Acad Sci U S A, 110:8882-8887, . (PMID: 23671091, PMCID: PMC3670379)

Koyuncu, E. Purdy, J. G. Rabinowitz, J. D. Shenk, T. Saturated very long chain fatty acids are required for the production of infectious human cytomegalovirus progeny. PLoS Pathog, 9:e1003333, . (PMID: 23696731, PMCID: PMC3656100)

Shlomi, T. Rabinowitz, J. D. Metabolism: Cancer mistunes methylation. Nat Chem Biol, 9:293-294, . (PMID: 23594782, PMCID: PMC3733116)

Xu, Y. F. Letisse, F. Absalan, F. Lu, W. Kuznetsova, E. Brown, G. Caudy, A. A. Yakunin, A. F. Broach, J. R. Rabinowitz, J. D. Nucleotide degradation and ribose salvage in yeast. Mol Syst Biol, 9:665, . (PMID: 23670538)

Fan, J. Kamphorst, J. J. Mathew, R. Chung, M. K. White, E. Shlomi, T. Rabinowitz, J. D. Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia. Mol Syst Biol, 9:712, . (PMID: 24301801, PMCID: PMC3882799)

Xu, Y. F. Zhao, X. Glass, D. S. Absalan, F. Perlman, D. H. Broach, J. R. Rabinowitz, J. D. Regulation of yeast pyruvate kinase by ultrasensitive allostery independent of phosphorylation. Mol Cell, 48:52-62, . (PMID: 22902555, PMCID: PMC3472130)

Grady, S. L. Hwang, J. Vastag, L. Rabinowitz, J. D. Shenk, T. Herpes Simplex Virus 1 Infection Activates Poly(ADP-Ribose) Polymerase and Triggers the Degradation of Poly(ADP-Ribose) Glycohydrolase. J Virol, 86:8259-8268, . (PMID: 22623791, PMCID: PMC3421676)

Reaves, M. L. Sinha, S. Rabinowitz, J. D. Kruglyak, L. Redfield, R. J. Absence of detectable arsenate in DNA from arsenate-grown GFAJ-1 cells. Science, 337:470-473, . (PMID: 22773140)

Rabinowitz, J. D. Vastag, L. Teaching the design principles of metabolism. Nat Chem Biol, 8:497-501, . (PMID: 22596190)

Xu, Y. F. Amador-Noguez, D. Reaves, M. L. Feng, X. J. Rabinowitz, J. D. Ultrasensitive regulation of anapleurosis via allosteric activation of PEP carboxylase. Nat Chem Biol, 8:562-568, . (PMID: 22522319, PMCID: PMC3433955)

Ye, J. Mancuso, A. Tong, X. Ward, P. S. Fan, J. Rabinowitz, J. D. Thompson, C. B. Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation. Proc Natl Acad Sci U S A, 109:6904-6909, . (PMID: 22509023, PMCID: PMC3345000)

Peterson, C. N. Levchenko, I. Rabinowitz, J. D. Baker, T. A. Silhavy, T. J. RpoS proteolysis is controlled directly by ATP levels in Escherichia coli. Genes Dev, 26:548-553, . (PMID: 22426532, PMCID: PMC3315116)

Clasquin, M. F. Melamud, E. Rabinowitz, J. D. LC-MS data processing with MAVEN: a metabolomic analysis and visualization engine. Curr Protoc Bioinformatics, Chapter 14:Unit14.11, . (PMID: 22389014)

Terry, L. J. Vastag, L. Rabinowitz, J. D. Shenk, T. Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection. Proc Natl Acad Sci U S A, 109:3071-3076, . (PMID: 22315427, PMCID: PMC3286917)

Bray, K. Mathew, R. Lau, A. Kamphorst, J. J. Fan, J. Chen, J. Chen, H. Y. Ghavami, A. Stein, M. Dipaola, R. S. Zhang, D. Rabinowitz, J. D. White, E. Autophagy Suppresses RIP Kinase-Dependent Necrosis Enabling Survival to mTOR Inhibition. PLoS One, 7:e41831, . (PMID: 22848625, PMCID: PMC3406086)

Kamphorst, J. J. Fan, J. Lu, W. White, E. Rabinowitz, J. D. Liquid chromatography-high resolution mass spectrometry analysis of fatty acid metabolism. Anal Chem, 83:9114-9122, . (PMID: 22004349, PMCID: PMC3230881)

Doucette, C. D. Schwab, D. J. Wingreen, N. S. Rabinowitz, J. D. alpha-Ketoglutarate coordinates carbon and nitrogen utilization via enzyme I inhibition. Nat Chem Biol, 7:894-901, . (PMID: 22002719, PMCID: PMC3218208)

Petti, A. A. Crutchfield, C. A. Rabinowitz, J. D. Botstein, D. Survival of starving yeast is correlated with oxidative stress response and nonrespiratory mitochondrial function. Proc Natl Acad Sci U S A, 108:E1089-E1098, . (PMID: 21734149, PMCID: PMC3215077)

Amador-Noguez, D. Brasg, I. A. Feng, X. J. Roquet, N. Rabinowitz, J. D. Metabolome remodeling during the acidogenic-solventogenic transition in Clostridium acetobutylicum. Appl Environ Microbiol, 77:7984-7997, . (PMID: 21948824, PMCID: PMC3209008)

Strelko, C. L. Lu, W. Dufort, F. J. Seyfried, T. N. Chiles, T. C. Rabinowitz, J. D. Roberts, M. F. Itaconic acid is a mammalian metabolite induced during macrophage activation. J Am Chem Soc, 133:16386-16389, . (PMID: 21919507, PMCID: PMC3216473)

Reaves, M. L. Rabinowitz, J. D. Characteristic phenotypes associated with ptsN-null mutants in Escherichia coli K-12 are absent in strains with functional ilvG. J Bacteriol, 193:4576-4581, . (PMID: 21531803, PMCID: PMC3165713)

Liu, S. T. Sharon-Friling, R. Ivanova, P. Milne, S. B. Myers, D. S. Rabinowitz, J. D. Brown, H. A. Shenk, T. Synaptic vesicle-like lipidome of human cytomegalovirus virions reveals a role for SNARE machinery in virion egress. Proc Natl Acad Sci U S A, 108:12869-12874, . (PMID: 21768361, PMCID: PMC3150939)

Vastag, L. Koyuncu, E. Grady, S. L. Shenk, T. E. Rabinowitz, J. D. Divergent effects of human cytomegalovirus and herpes simplex virus-1 on cellular metabolism. PLoS Pathog, 7:e1002124, . (PMID: 21779165, PMCID: PMC3136460)

Clasquin, M. F. Melamud, E. Singer, A. Gooding, J. R. Xu, X. Dong, A. Cui, H. Campagna, S. R. Savchenko, A. Yakunin, A. F. Rabinowitz, J. D. Caudy, A. A. Riboneogenesis in yeast. Cell, 145:969-980, . (PMID: 21663798, PMCID: PMC3163394)

Guo, J. Y. Chen, H. Y. Mathew, R. Fan, J. Strohecker, A. M. Karsli-Uzunbas, G. Kamphorst, J. J. Chen, G. Lemons, J. M. Karantza, V. Coller, H. A. Dipaola, R. S. Gelinas, C. Rabinowitz, J. D. White, E. Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev, 25:460-470, . (PMID: 21317241, PMCID: PMC3049287)

Klosinska, M. M. Crutchfield, C. A. Bradley, P. H. Rabinowitz, J. D. Broach, J. R. Yeast cells can access distinct quiescent states. Genes Dev, 25:336-349, . (PMID: 21289062, PMCID: PMC3042157)

Reaves, M. L. Rabinowitz, J. D. Metabolomics in systems microbiology. Curr Opin Biotechnol, 22:17-25, . (PMID: 21050741, PMCID: PMC3035947)

Hart, Y. Madar, D. Yuan, J. Bren, A. Mayo, A. E. Rabinowitz, J. D. Alon, U. Robust control of nitrogen assimilation by a bifunctional enzyme in E. coli. Mol Cell, 41:117-127, . (PMID: 21211727)

Vastag, L. Jorgensen, P. Peshkin, L. Wei, R. Rabinowitz, J. D. Kirschner, M. W. Remodeling of the metabolome during early frog development. PLoS One, 6:e16881, . (PMID: 21347444, PMCID: PMC3035664)

Rabinowitz, J. D. Purdy, J. G. Vastag, L. Shenk, T. Koyuncu, E. Metabolomics in drug target discovery. Cold Spring Harb Symp Quant Biol, 76:235-246, . (PMID: 22114327)