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Joshua D. Rabinowitz, MD, PhD

Publications since 2011

Ducker, G. S. Chen, L. Morscher, R. J. Ghergurovich, J. M. Esposito, M. Teng, X. Kang, Y. Rabinowitz, J. D. Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway. Cell Metab, In process, . (PMID: 27211901)

Park, J. O. Rubin, S. A. Xu, Y. F. Amador-Noguez, D. Fan, J. Shlomi, T. Rabinowitz, J. D. Metabolite concentrations, fluxes and free energies imply efficient enzyme usage. Nat Chem Biol, In process, . (PMID: 27159581)

Liu, L. Shah, S. Fan, J. Park, J. O. Wellen, K. E. Rabinowitz, J. D. Malic enzyme tracers reveal hypoxia-induced switch in adipocyte NADPH pathway usage. Nat Chem Biol, In process, . (PMID: 26999781)

Jang, C. Oh, S. F. Wada, S. Rowe, G. C. Liu, L. Chan, M. C. Rhee, J. Hoshino, A. Kim, B. Ibrahim, A. Baca, L. G. Kim, E. Ghosh, C. C. Parikh, S. M. Jiang, A. Chu, Q. Forman, D. E. Lecker, S. H. Krishnaiah, S. Rabinowitz, J. D. Weljie, A. M. Baur, J. A. Kasper, D. L. Arany, Z. A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance. Nat Med, In process, . (PMID: 26950361)

Zong, W. X. Rabinowitz, J. D. White, E. Mitochondria and Cancer. Mol Cell, 61:667-676, . (PMID: 26942671, PMCID: PMC4779192)

Rabinowitz, J. D. Coller, H. A. Partners in the Warburg effect. Elife, 5:, . (PMID: 27073176)

Bren, A. Park, J. O. Towbin, B. D. Dekel, E. Rabinowitz, J. D. Alon, U. Glucose becomes one of the worst carbon sources for E.coli on poor nitrogen sources due to suboptimal levels of cAMP. Sci Rep, 6:24834, . (PMID: 27109914, PMCID: PMC4843011)

Su, X. Wellen, K. E. Rabinowitz, J. D. Metabolic control of methylation and acetylation. Curr Opin Chem Biol, In process, . (PMID: 26629854)

Bott, A. J. Peng, I. C. Fan, Y. Faubert, B. Zhao, L. Li, J. Neidler, S. Sun, Y. Jaber, N. Krokowski, D. Lu, W. Pan, J. A. Powers, S. Rabinowitz, J. Hatzoglou, M. Murphy, D. J. Jones, R. Wu, S. Girnun, G. Zong, W. X. Oncogenic Myc Induces Expression of Glutamine Synthetase through Promoter Demethylation. Cell Metab, In process, . (PMID: 26603296)

Rajeshkumar, N. V. Dutta, P. Yabuuchi, S. de Wilde, R. F. Matrinez, G. V. Le, A. Kamphorst, J. J. Rabinowitz, J. D. Jain, S. K. Hidalgo, M. Dang, C. V. Gillies, R. J. Maitra, A. Therapeutic targeting of the Warburg effect in pancreatic cancer relies on an absence of p53 function. Cancer Res, In process, . (PMID: 26113084)

Gibney, P. A. Schieler, A. Chen, J. C. Rabinowitz, J. D. Botstein, D. Characterizing the in vivo role of trehalose in Saccharomyces cerevisiae using the AGT1 transporter. Proc Natl Acad Sci U S A, In process, . (PMID: 25918382)

Purdy, J. G. Shenk, T. Rabinowitz, J. D. Fatty Acid elongase 7 catalyzes lipidome remodeling essential for human cytomegalovirus replication. Cell Rep, 10:1375-1385, . (PMID: 25732827)

Buescher, J. M. Antoniewicz, M. R. Boros, L. G. Burgess, S. C. Brunengraber, H. Clish, C. B. DeBerardinis, R. J. Feron, O. Frezza, C. Ghesquiere, B. Gottlieb, E. Hiller, K. Jones, R. G. Kamphorst, J. J. Kibbey, R. G. Kimmelman, A. C. Locasale, J. W. Lunt, S. Y. Maddocks, O. D. Malloy, C. Metallo, C. M. Meuillet, E. J. Munger, J. Noh, K. Rabinowitz, J. D. Ralser, M. Sauer, U. Stephanopoulos, G. St-Pierre, J. Tennant, D. A. Wittmann, C. Vander Heiden, M. G. Vazquez, A. Vousden, K. Young, J. D. Zamboni, N. Fendt, S. M. A roadmap for interpreting C metabolite labeling patterns from cells. Curr Opin Biotechnol, In process, . (PMID: 25731751)

Xu, Y. F. Lu, W. Rabinowitz, J. D. Avoiding misannotation of in-source fragmentation products as cellular metabolites in liquid chromatography-mass spectrometry-based metabolomics. Anal Chem, 87:2273-2281, . (PMID: 25591916, PMCID: PMC4354698)

Kamphorst, J. J. Nofal, M. Commisso, C. Hackett, S. R. Lu, W. Grabocka, E. Vander Heiden, M. G. Miller, G. Drebin, J. A. Bar-Sagi, D. Thompson, C. B. Rabinowitz, J. D. Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein. Cancer Res, 75:544-553, . (PMID: 25644265, PMCID: PMC4316379)

Ducker, G. S. Rabinowitz, J. D. ZMP: A Master Regulator of One-Carbon Metabolism. Mol Cell, 57:203-204, . (PMID: 25616065)

Aristilde, L. Lewis, I. A. Park, J. O. Rabinowitz, J. D. Hierarchy in Pentose Sugar Metabolism in Clostridium Acetobutylicum. Appl Environ Microbiol, In process, . (PMID: 25527534)

Hwang, J. Purdy, J. G. Wu, K. Rabinowitz, J. D. Shenk, T. Estrogen-related receptor alpha is required for efficient human cytomegalovirus replication. Proc Natl Acad Sci U S A, In process, . (PMID: 25512541)

Fan, J. Teng, X. Liu, L. Mattaini, K. R. Looper, R. E. Vander Heiden, M. G. Rabinowitz, J. D. Human Phosphoglycerate Dehydrogenase Produces the Oncometabolite d-2-Hydroxyglutarate. ACS Chem Biol, In process, . (PMID: 25406093)

Zhang, J. Fan, J. Venneti, S. Cross, J. R. Takagi, T. Bhinder, B. Djaballah, H. Kanai, M. Cheng, E. H. Judkins, A. R. Pawel, B. Baggs, J. Cherry, S. Rabinowitz, J. D. Thompson, C. B. Asparagine Plays a Critical Role in Regulating Cellular Adaptation to Glutamine Depletion. Mol Cell, 56:205-218, . (PMID: 25242145, PMCID: PMC4224619)

Castellana, M. Wilson, M. Z. Xu, Y. Joshi, P. Cristea, I. M. Rabinowitz, J. D. Gitai, Z. Wingreen, N. S. Enzyme clustering accelerates processing of intermediates through metabolic channeling. Nat Biotechnol, 32:1011-1018, . (PMID: 25262299)

Stincone, A. Prigione, A. Cramer, T. Wamelink, M. M. Campbell, K. Cheung, E. Olin-Sandoval, V. Gruening, N. M. Krueger, A. Tauqeer Alam, M. Keller, M. A. Breitenbach, M. Brindle, K. M. Rabinowitz, J. D. Ralser, M. The return of metabolism: biochemistry and physiology of the pentose phosphate pathway. Biol Rev Camb Philos Soc, In process, . (PMID: 25243985)

Mathew, R. Khor, S. Hackett, S. R. Rabinowitz, J. D. Perlman, D. H. White, E. Functional Role of Autophagy-Mediated Proteome Remodeling in Cell Survival Signaling and Innate Immunity. Mol Cell, 55:916-930, . (PMID: 25175026, PMCID: PMC4169768)

Ye, J. Fan, J. Venneti, S. Wan, Y. W. Pawel, B. R. Zhang, J. Finley, L. W. Lu, C. Lindsten, T. Cross, J. Qing, G. Liu, Z. Simon, M. C. Rabinowitz, J. D. Thompson, C. B. Serine catabolism regulates mitochondrial redox control during hypoxia. Cancer Discov, In process, . (PMID: 25186948)

Karsli-Uzunbas, G. Guo, J. Y. Price, S. M. Teng, X. Laddha, S. V. Khor, S. Kalaany, N. Y. Jacks, T. Chan, C. S. Rabinowitz, J. D. White, E. Autophagy is Required for Glucose Homeostasis and Lung Tumor Maintenance. Cancer Discov, 4:914-927, . (PMID: 24875857, PMCID: PMC4125614)

Fan, J. Ye, J. Kamphorst, J. J. Shlomi, T. Thompson, C. B. Rabinowitz, J. D. Quantitative flux analysis reveals folate-dependent NADPH production. Nature, 510:298-302, . (PMID: 24805240, PMCID: PMC4104482)

Breunig, J. S. Hackett, S. R. Rabinowitz, J. D. Kruglyak, L. Genetic basis of metabolome variation in yeast. PLoS Genet, 10:e1004142, . (PMID: 24603560, PMCID: PMC3945093)

Shlomi, T. Fan, J. Tang, B. Kruger, W. D. Rabinowitz, J. D. Quantitation of cellular metabolic fluxes of methionine. Anal Chem, 86:1583-1591, . (PMID: 24397525, PMCID: PMC4060246)

Kamphorst, J. J. Chung, M. K. Fan, J. Rabinowitz, J. D. Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate. Cancer Metab, 2:23, . (PMID: 25671109, PMCID: PMC4322440)

Kliegman, J. I. Fiedler, D. Ryan, C. J. Xu, Y. F. Su, X. Y. Thomas, D. Caccese, M. C. Cheng, A. Shales, M. Rabinowitz, J. D. Krogan, N. J. Shokat, K. M. Chemical Genetics of Rapamycin-Insensitive TORC2 in S. cerevisiae. Cell Rep, 5:1725-1736, . (PMID: 24360963, PMCID: PMC4007695)

Grady, S. L. Purdy, J. G. Rabinowitz, J. D. Shenk, T. Argininosuccinate synthetase 1 depletion produces a metabolic state conducive to herpes simplex virus 1 infection. Proc Natl Acad Sci U S A, 110:E5006-E5015, . (PMID: 24297925, PMCID: PMC3870743)

Tchigvintsev, A. Tchigvintsev, D. Flick, R. Popovic, A. Dong, A. Xu, X. Brown, G. Lu, W. Wu, H. Cui, H. Dombrowski, L. Joo, J. C. Beloglazova, N. Min, J. Savchenko, A. Caudy, A. A. Rabinowitz, J. D. Murzin, A. G. Yakunin, A. F. Biochemical and structural studies of conserved Maf proteins revealed nucleotide pyrophosphatases with a preference for modified nucleotides. Chem Biol, 20:1386-1398, . (PMID: 24210219, PMCID: PMC3899018)

Fan, J. Kamphorst, J. J. Rabinowitz, J. D. Shlomi, T. Fatty acid labeling from glutamine in hypoxia can be explained by isotope exchange without net reductive IDH flux. J Biol Chem, 288:31363-31369, . (PMID: 24030823, PMCID: PMC3829450)

Rabinowitz, J. D. Silhavy, T. J. Systems biology: metabolite turns master regulator. Nature, 500:283-284, . (PMID: 23925111)

Reaves, M. L. Young, B. D. Hosios, A. M. Xu, Y. F. Rabinowitz, J. D. Pyrimidine homeostasis is accomplished by directed overflow metabolism. Nature, 500:237-241, . (PMID: 23903661)

Guo, J. Y. Karsli-Uzunbas, G. Mathew, R. Aisner, S. C. Kamphorst, J. J. Strohecker, A. M. Chen, G. Price, S. Lu, W. Teng, X. Snyder, E. Santanam, U. Dipaola, R. S. Jacks, T. Rabinowitz, J. D. White, E. Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes Dev, 27:1447-1461, . (PMID: 23824538, PMCID: PMC3713426)

Commisso, C. Davidson, S. M. Soydaner-Azeloglu, R. G. Parker, S. J. Kamphorst, J. J. Hackett, S. Grabocka, E. Nofal, M. Drebin, J. A. Thompson, C. B. Rabinowitz, J. D. Metallo, C. M. Vander Heiden, M. G. Bar-Sagi, D. Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature, 497:633-637, . (PMID: 23665962)

Olszewski, K. L. Mather, M. W. Morrisey, J. M. Garcia, B. A. Vaidya, A. B. Rabinowitz, J. D. Llinas, M. Retraction: Branched tricarboxylic acid metabolism in Plasmodium falciparum. Nature, 497:652, . (PMID: 23615611)

Kamphorst, J. J. Cross, J. R. Fan, J. de Stanchina, E. Mathew, R. White, E. P. Thompson, C. B. Rabinowitz, J. D. Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids. Proc Natl Acad Sci U S A, 110:8882-8887, . (PMID: 23671091, PMCID: PMC3670379)

Koyuncu, E. Purdy, J. G. Rabinowitz, J. D. Shenk, T. Saturated very long chain fatty acids are required for the production of infectious human cytomegalovirus progeny. PLoS Pathog, 9:e1003333, . (PMID: 23696731, PMCID: PMC3656100)

Shlomi, T. Rabinowitz, J. D. Metabolism: Cancer mistunes methylation. Nat Chem Biol, 9:293-294, . (PMID: 23594782, PMCID: PMC3733116)

Xu, Y. F. Letisse, F. Absalan, F. Lu, W. Kuznetsova, E. Brown, G. Caudy, A. A. Yakunin, A. F. Broach, J. R. Rabinowitz, J. D. Nucleotide degradation and ribose salvage in yeast. Mol Syst Biol, 9:665, . (PMID: 23670538)

Fan, J. Kamphorst, J. J. Mathew, R. Chung, M. K. White, E. Shlomi, T. Rabinowitz, J. D. Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia. Mol Syst Biol, 9:712, . (PMID: 24301801, PMCID: PMC3882799)

Xu, Y. F. Zhao, X. Glass, D. S. Absalan, F. Perlman, D. H. Broach, J. R. Rabinowitz, J. D. Regulation of yeast pyruvate kinase by ultrasensitive allostery independent of phosphorylation. Mol Cell, 48:52-62, . (PMID: 22902555, PMCID: PMC3472130)

Grady, S. L. Hwang, J. Vastag, L. Rabinowitz, J. D. Shenk, T. Herpes Simplex Virus 1 Infection Activates Poly(ADP-Ribose) Polymerase and Triggers the Degradation of Poly(ADP-Ribose) Glycohydrolase. J Virol, 86:8259-8268, . (PMID: 22623791, PMCID: PMC3421676)

Reaves, M. L. Sinha, S. Rabinowitz, J. D. Kruglyak, L. Redfield, R. J. Absence of detectable arsenate in DNA from arsenate-grown GFAJ-1 cells. Science, 337:470-473, . (PMID: 22773140)

Rabinowitz, J. D. Vastag, L. Teaching the design principles of metabolism. Nat Chem Biol, 8:497-501, . (PMID: 22596190)

Xu, Y. F. Amador-Noguez, D. Reaves, M. L. Feng, X. J. Rabinowitz, J. D. Ultrasensitive regulation of anapleurosis via allosteric activation of PEP carboxylase. Nat Chem Biol, 8:562-568, . (PMID: 22522319, PMCID: PMC3433955)

Ye, J. Mancuso, A. Tong, X. Ward, P. S. Fan, J. Rabinowitz, J. D. Thompson, C. B. Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation. Proc Natl Acad Sci U S A, 109:6904-6909, . (PMID: 22509023, PMCID: PMC3345000)

Peterson, C. N. Levchenko, I. Rabinowitz, J. D. Baker, T. A. Silhavy, T. J. RpoS proteolysis is controlled directly by ATP levels in Escherichia coli. Genes Dev, 26:548-553, . (PMID: 22426532, PMCID: PMC3315116)

Clasquin, M. F. Melamud, E. Rabinowitz, J. D. LC-MS data processing with MAVEN: a metabolomic analysis and visualization engine. Curr Protoc Bioinformatics, Chapter 14:Unit14.11, . (PMID: 22389014)

Terry, L. J. Vastag, L. Rabinowitz, J. D. Shenk, T. Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection. Proc Natl Acad Sci U S A, 109:3071-3076, . (PMID: 22315427, PMCID: PMC3286917)

Bray, K. Mathew, R. Lau, A. Kamphorst, J. J. Fan, J. Chen, J. Chen, H. Y. Ghavami, A. Stein, M. Dipaola, R. S. Zhang, D. Rabinowitz, J. D. White, E. Autophagy Suppresses RIP Kinase-Dependent Necrosis Enabling Survival to mTOR Inhibition. PLoS One, 7:e41831, . (PMID: 22848625, PMCID: PMC3406086)

Kamphorst, J. J. Fan, J. Lu, W. White, E. Rabinowitz, J. D. Liquid chromatography-high resolution mass spectrometry analysis of fatty acid metabolism. Anal Chem, 83:9114-9122, . (PMID: 22004349, PMCID: PMC3230881)

Doucette, C. D. Schwab, D. J. Wingreen, N. S. Rabinowitz, J. D. alpha-Ketoglutarate coordinates carbon and nitrogen utilization via enzyme I inhibition. Nat Chem Biol, 7:894-901, . (PMID: 22002719, PMCID: PMC3218208)

Petti, A. A. Crutchfield, C. A. Rabinowitz, J. D. Botstein, D. Survival of starving yeast is correlated with oxidative stress response and nonrespiratory mitochondrial function. Proc Natl Acad Sci U S A, 108:E1089-E1098, . (PMID: 21734149, PMCID: PMC3215077)

Amador-Noguez, D. Brasg, I. A. Feng, X. J. Roquet, N. Rabinowitz, J. D. Metabolome remodeling during the acidogenic-solventogenic transition in Clostridium acetobutylicum. Appl Environ Microbiol, 77:7984-7997, . (PMID: 21948824, PMCID: PMC3209008)

Strelko, C. L. Lu, W. Dufort, F. J. Seyfried, T. N. Chiles, T. C. Rabinowitz, J. D. Roberts, M. F. Itaconic acid is a mammalian metabolite induced during macrophage activation. J Am Chem Soc, 133:16386-16389, . (PMID: 21919507, PMCID: PMC3216473)

Reaves, M. L. Rabinowitz, J. D. Characteristic phenotypes associated with ptsN-null mutants in Escherichia coli K-12 are absent in strains with functional ilvG. J Bacteriol, 193:4576-4581, . (PMID: 21531803, PMCID: PMC3165713)

Liu, S. T. Sharon-Friling, R. Ivanova, P. Milne, S. B. Myers, D. S. Rabinowitz, J. D. Brown, H. A. Shenk, T. Synaptic vesicle-like lipidome of human cytomegalovirus virions reveals a role for SNARE machinery in virion egress. Proc Natl Acad Sci U S A, 108:12869-12874, . (PMID: 21768361, PMCID: PMC3150939)

Vastag, L. Koyuncu, E. Grady, S. L. Shenk, T. E. Rabinowitz, J. D. Divergent effects of human cytomegalovirus and herpes simplex virus-1 on cellular metabolism. PLoS Pathog, 7:e1002124, . (PMID: 21779165, PMCID: PMC3136460)

Clasquin, M. F. Melamud, E. Singer, A. Gooding, J. R. Xu, X. Dong, A. Cui, H. Campagna, S. R. Savchenko, A. Yakunin, A. F. Rabinowitz, J. D. Caudy, A. A. Riboneogenesis in yeast. Cell, 145:969-980, . (PMID: 21663798, PMCID: PMC3163394)

Guo, J. Y. Chen, H. Y. Mathew, R. Fan, J. Strohecker, A. M. Karsli-Uzunbas, G. Kamphorst, J. J. Chen, G. Lemons, J. M. Karantza, V. Coller, H. A. Dipaola, R. S. Gelinas, C. Rabinowitz, J. D. White, E. Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev, 25:460-470, . (PMID: 21317241, PMCID: PMC3049287)

Klosinska, M. M. Crutchfield, C. A. Bradley, P. H. Rabinowitz, J. D. Broach, J. R. Yeast cells can access distinct quiescent states. Genes Dev, 25:336-349, . (PMID: 21289062, PMCID: PMC3042157)

Reaves, M. L. Rabinowitz, J. D. Metabolomics in systems microbiology. Curr Opin Biotechnol, 22:17-25, . (PMID: 21050741, PMCID: PMC3035947)

Hart, Y. Madar, D. Yuan, J. Bren, A. Mayo, A. E. Rabinowitz, J. D. Alon, U. Robust control of nitrogen assimilation by a bifunctional enzyme in E. coli. Mol Cell, 41:117-127, . (PMID: 21211727)

Vastag, L. Jorgensen, P. Peshkin, L. Wei, R. Rabinowitz, J. D. Kirschner, M. W. Remodeling of the metabolome during early frog development. PLoS One, 6:e16881, . (PMID: 21347444, PMCID: PMC3035664)

Rabinowitz, J. D. Purdy, J. G. Vastag, L. Shenk, T. Koyuncu, E. Metabolomics in drug target discovery. Cold Spring Harb Symp Quant Biol, 76:235-246, . (PMID: 22114327)