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Joshua D. Rabinowitz, MD, PhD

Publications since 2011

Zhang, J. Fan, J. Venneti, S. Cross, J. R. Takagi, T. Bhinder, B. Djaballah, H. Kanai, M. Cheng, E. H. Judkins, A. R. Pawel, B. Baggs, J. Cherry, S. Rabinowitz, J. D. Thompson, C. B. Asparagine Plays a Critical Role in Regulating Cellular Adaptation to Glutamine Depletion. Mol Cell, In process, . (PMID: 25242145)

Ye, J. Fan, J. Venneti, S. Wan, Y. W. Pawel, B. R. Zhang, J. Finley, L. W. Lu, C. Lindsten, T. Cross, J. Qing, G. Liu, Z. Simon, M. C. Rabinowitz, J. D. Thompson, C. B. Serine catabolism regulates mitochondrial redox control during hypoxia. Cancer Discov, In process, . (PMID: 25186948)

Mathew, R. Khor, S. Hackett, S. R. Rabinowitz, J. D. Perlman, D. H. White, E. Functional Role of Autophagy-Mediated Proteome Remodeling in Cell Survival Signaling and Innate Immunity. Mol Cell, In process, . (PMID: 25175026)

Karsli-Uzunbas, G. Guo, J. Y. Price, S. M. Teng, X. Laddha, S. V. Khor, S. Kalaany, N. Y. Jacks, T. Chan, C. S. Rabinowitz, J. D. White, E. Autophagy is Required for Glucose Homeostasis and Lung Tumor Maintenance. Cancer Discov, 4:914-927, . (PMID: 24875857, PMCID: PMC4125614)

Fan, J. Ye, J. Kamphorst, J. J. Shlomi, T. Thompson, C. B. Rabinowitz, J. D. Quantitative flux analysis reveals folate-dependent NADPH production. Nature, 510:298-302, . (PMID: 24805240, PMCID: PMC4104482)

Breunig, J. S. Hackett, S. R. Rabinowitz, J. D. Kruglyak, L. Genetic basis of metabolome variation in yeast. PLoS Genet, 10:e1004142, . (PMID: 24603560, PMCID: PMC3945093)

Kliegman, J. I. Fiedler, D. Ryan, C. J. Xu, Y. F. Su, X. Y. Thomas, D. Caccese, M. C. Cheng, A. Shales, M. Rabinowitz, J. D. Krogan, N. J. Shokat, K. M. Chemical Genetics of Rapamycin-Insensitive TORC2 in S. cerevisiae. Cell Rep, 5:1725-1736, . (PMID: 24360963, PMCID: PMC4007695)

Grady, S. L. Purdy, J. G. Rabinowitz, J. D. Shenk, T. Argininosuccinate synthetase 1 depletion produces a metabolic state conducive to herpes simplex virus 1 infection. Proc Natl Acad Sci U S A, 110:E5006-E5015, . (PMID: 24297925, PMCID: PMC3870743)

Rabinowitz, J. D. Silhavy, T. J. Systems biology: metabolite turns master regulator. Nature, 500:283-284, . (PMID: 23925111)

Reaves, M. L. Young, B. D. Hosios, A. M. Xu, Y. F. Rabinowitz, J. D. Pyrimidine homeostasis is accomplished by directed overflow metabolism. Nature, 500:237-241, . (PMID: 23903661)

Guo, J. Y. Karsli-Uzunbas, G. Mathew, R. Aisner, S. C. Kamphorst, J. J. Strohecker, A. M. Chen, G. Price, S. Lu, W. Teng, X. Snyder, E. Santanam, U. Dipaola, R. S. Jacks, T. Rabinowitz, J. D. White, E. Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes Dev, 27:1447-1461, . (PMID: 23824538, PMCID: PMC3713426)

Commisso, C. Davidson, S. M. Soydaner-Azeloglu, R. G. Parker, S. J. Kamphorst, J. J. Hackett, S. Grabocka, E. Nofal, M. Drebin, J. A. Thompson, C. B. Rabinowitz, J. D. Metallo, C. M. Vander Heiden, M. G. Bar-Sagi, D. Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature, 497:633-637, . (PMID: 23665962)

Olszewski, K. L. Mather, M. W. Morrisey, J. M. Garcia, B. A. Vaidya, A. B. Rabinowitz, J. D. Llinas, M. Retraction: Branched tricarboxylic acid metabolism in Plasmodium falciparum. Nature, 497:652, . (PMID: 23615611)

Kamphorst, J. J. Cross, J. R. Fan, J. de Stanchina, E. Mathew, R. White, E. P. Thompson, C. B. Rabinowitz, J. D. Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids. Proc Natl Acad Sci U S A, 110:8882-8887, . (PMID: 23671091, PMCID: PMC3670379)

Koyuncu, E. Purdy, J. G. Rabinowitz, J. D. Shenk, T. Saturated very long chain fatty acids are required for the production of infectious human cytomegalovirus progeny. PLoS Pathog, 9:e1003333, . (PMID: 23696731, PMCID: PMC3656100)

Shlomi, T. Rabinowitz, J. D. Metabolism: Cancer mistunes methylation. Nat Chem Biol, 9:293-294, . (PMID: 23594782, PMCID: PMC3733116)

Xu, Y. F. Letisse, F. Absalan, F. Lu, W. Kuznetsova, E. Brown, G. Caudy, A. A. Yakunin, A. F. Broach, J. R. Rabinowitz, J. D. Nucleotide degradation and ribose salvage in yeast. Mol Syst Biol, 9:665, . (PMID: 23670538)

Fan, J. Kamphorst, J. J. Mathew, R. Chung, M. K. White, E. Shlomi, T. Rabinowitz, J. D. Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia. Mol Syst Biol, 9:712, . (PMID: 24301801, PMCID: PMC3882799)

Xu, Y. F. Zhao, X. Glass, D. S. Absalan, F. Perlman, D. H. Broach, J. R. Rabinowitz, J. D. Regulation of yeast pyruvate kinase by ultrasensitive allostery independent of phosphorylation. Mol Cell, 48:52-62, . (PMID: 22902555, PMCID: PMC3472130)

Grady, S. L. Hwang, J. Vastag, L. Rabinowitz, J. D. Shenk, T. Herpes Simplex Virus 1 Infection Activates Poly(ADP-Ribose) Polymerase and Triggers the Degradation of Poly(ADP-Ribose) Glycohydrolase. J Virol, 86:8259-8268, . (PMID: 22623791, PMCID: PMC3421676)

Reaves, M. L. Sinha, S. Rabinowitz, J. D. Kruglyak, L. Redfield, R. J. Absence of detectable arsenate in DNA from arsenate-grown GFAJ-1 cells. Science, 337:470-473, . (PMID: 22773140)

Rabinowitz, J. D. Vastag, L. Teaching the design principles of metabolism. Nat Chem Biol, 8:497-501, . (PMID: 22596190)

Xu, Y. F. Amador-Noguez, D. Reaves, M. L. Feng, X. J. Rabinowitz, J. D. Ultrasensitive regulation of anapleurosis via allosteric activation of PEP carboxylase. Nat Chem Biol, 8:562-568, . (PMID: 22522319, PMCID: PMC3433955)

Ye, J. Mancuso, A. Tong, X. Ward, P. S. Fan, J. Rabinowitz, J. D. Thompson, C. B. Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation. Proc Natl Acad Sci U S A, 109:6904-6909, . (PMID: 22509023, PMCID: PMC3345000)

Peterson, C. N. Levchenko, I. Rabinowitz, J. D. Baker, T. A. Silhavy, T. J. RpoS proteolysis is controlled directly by ATP levels in Escherichia coli. Genes Dev, 26:548-553, . (PMID: 22426532, PMCID: PMC3315116)

Clasquin, M. F. Melamud, E. Rabinowitz, J. D. LC-MS data processing with MAVEN: a metabolomic analysis and visualization engine. Curr Protoc Bioinformatics, Chapter 14:Unit14.11, . (PMID: 22389014)

Terry, L. J. Vastag, L. Rabinowitz, J. D. Shenk, T. Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection. Proc Natl Acad Sci U S A, 109:3071-3076, . (PMID: 22315427, PMCID: PMC3286917)

Bray, K. Mathew, R. Lau, A. Kamphorst, J. J. Fan, J. Chen, J. Chen, H. Y. Ghavami, A. Stein, M. Dipaola, R. S. Zhang, D. Rabinowitz, J. D. White, E. Autophagy Suppresses RIP Kinase-Dependent Necrosis Enabling Survival to mTOR Inhibition. PLoS One, 7:e41831, . (PMID: 22848625, PMCID: PMC3406086)

Kamphorst, J. J. Fan, J. Lu, W. White, E. Rabinowitz, J. D. Liquid chromatography-high resolution mass spectrometry analysis of fatty acid metabolism. Anal Chem, 83:9114-9122, . (PMID: 22004349, PMCID: PMC3230881)

Doucette, C. D. Schwab, D. J. Wingreen, N. S. Rabinowitz, J. D. alpha-Ketoglutarate coordinates carbon and nitrogen utilization via enzyme I inhibition. Nat Chem Biol, 7:894-901, . (PMID: 22002719, PMCID: PMC3218208)

Petti, A. A. Crutchfield, C. A. Rabinowitz, J. D. Botstein, D. Survival of starving yeast is correlated with oxidative stress response and nonrespiratory mitochondrial function. Proc Natl Acad Sci U S A, 108:E1089-E1098, . (PMID: 21734149, PMCID: PMC3215077)

Amador-Noguez, D. Brasg, I. A. Feng, X. J. Roquet, N. Rabinowitz, J. D. Metabolome remodeling during the acidogenic-solventogenic transition in Clostridium acetobutylicum. Appl Environ Microbiol, 77:7984-7997, . (PMID: 21948824, PMCID: PMC3209008)

Strelko, C. L. Lu, W. Dufort, F. J. Seyfried, T. N. Chiles, T. C. Rabinowitz, J. D. Roberts, M. F. Itaconic acid is a mammalian metabolite induced during macrophage activation. J Am Chem Soc, 133:16386-16389, . (PMID: 21919507, PMCID: PMC3216473)

Reaves, M. L. Rabinowitz, J. D. Characteristic phenotypes associated with ptsN-null mutants in Escherichia coli K-12 are absent in strains with functional ilvG. J Bacteriol, 193:4576-4581, . (PMID: 21531803, PMCID: PMC3165713)

Liu, S. T. Sharon-Friling, R. Ivanova, P. Milne, S. B. Myers, D. S. Rabinowitz, J. D. Brown, H. A. Shenk, T. Synaptic vesicle-like lipidome of human cytomegalovirus virions reveals a role for SNARE machinery in virion egress. Proc Natl Acad Sci U S A, 108:12869-12874, . (PMID: 21768361, PMCID: PMC3150939)

Vastag, L. Koyuncu, E. Grady, S. L. Shenk, T. E. Rabinowitz, J. D. Divergent effects of human cytomegalovirus and herpes simplex virus-1 on cellular metabolism. PLoS Pathog, 7:e1002124, . (PMID: 21779165, PMCID: PMC3136460)

Clasquin, M. F. Melamud, E. Singer, A. Gooding, J. R. Xu, X. Dong, A. Cui, H. Campagna, S. R. Savchenko, A. Yakunin, A. F. Rabinowitz, J. D. Caudy, A. A. Riboneogenesis in yeast. Cell, 145:969-980, . (PMID: 21663798, PMCID: PMC3163394)

Guo, J. Y. Chen, H. Y. Mathew, R. Fan, J. Strohecker, A. M. Karsli-Uzunbas, G. Kamphorst, J. J. Chen, G. Lemons, J. M. Karantza, V. Coller, H. A. Dipaola, R. S. Gelinas, C. Rabinowitz, J. D. White, E. Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev, 25:460-470, . (PMID: 21317241, PMCID: PMC3049287)

Klosinska, M. M. Crutchfield, C. A. Bradley, P. H. Rabinowitz, J. D. Broach, J. R. Yeast cells can access distinct quiescent states. Genes Dev, 25:336-349, . (PMID: 21289062, PMCID: PMC3042157)

Reaves, M. L. Rabinowitz, J. D. Metabolomics in systems microbiology. Curr Opin Biotechnol, 22:17-25, . (PMID: 21050741, PMCID: PMC3035947)

Hart, Y. Madar, D. Yuan, J. Bren, A. Mayo, A. E. Rabinowitz, J. D. Alon, U. Robust control of nitrogen assimilation by a bifunctional enzyme in E. coli. Mol Cell, 41:117-127, . (PMID: 21211727)

Vastag, L. Jorgensen, P. Peshkin, L. Wei, R. Rabinowitz, J. D. Kirschner, M. W. Remodeling of the metabolome during early frog development. PLoS One, 6:e16881, . (PMID: 21347444, PMCID: PMC3035664)

Rabinowitz, J. D. Purdy, J. G. Vastag, L. Shenk, T. Koyuncu, E. Metabolomics in drug target discovery. Cold Spring Harb Symp Quant Biol, 76:235-246, . (PMID: 22114327)