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Virginia A. Zakian, PhD

Publications since 2011

Stundon, J. L. Zakian, V. A. Identification of Saccharomyces cerevisiae Genes Whose Deletion Causes Synthetic Effects in Cells with Reduced Levels of the Nuclear Pif1 DNA Helicase. G3 (Bethesda), In process, . (PMID: 26483010)

Webb, C. J. Zakian, V. A. Telomerase RNA stem terminus element affects template boundary element function, telomere sequence, and shelterin binding. Proc Natl Acad Sci U S A, In process, . (PMID: 26305931)

Phillips, J. A. Chan, A. Paeschke, K. Zakian, V. A. The pif1 helicase, a negative regulator of telomerase, acts preferentially at long telomeres. PLoS Genet, 11:e1005186, . (PMID: 25906395)

Lin, K. W. McDonald, K. R. Guise, A. J. Chan, A. Cristea, I. M. Zakian, V. A. Proteomics of yeast telomerase identified Cdc48-Npl4-Ufd1 and Ufd4 as regulators of Est1 and telomere length. Nat Commun, 6:8290, . (PMID: 26365526)

McDonald, K. R. Sabouri, N. Webb, C. J. Zakian, V. A. The Pif1 family helicase Pfh1 facilitates telomere replication and has an RPA-dependent role during telomere lengthening. DNA Repair (Amst), In process, . (PMID: 25303777)

Bochman, M. L. Paeschke, K. Chan, A. Zakian, V. A. Hrq1, a Homolog of the Human RecQ4 Helicase, Acts Catalytically and Structurally to Promote Genome Integrity. Cell Rep, 6:346-356, . (PMID: 24440721, PMCID: PMC3933191)

Zhou, R. Zhang, J. Bochman, M. L. Zakian, V. A. Ha, T. Periodic DNA patrolling underlies diverse functions of Pif1 on R-loops and G-rich DNA. Elife, 3:e02190, . (PMID: 24843019, PMCID: PMC3999857)

Sabouri, N. Capra, J. A. Zakian, V. A. The essential Schizosaccharomyces pombe Pfh1 DNA helicase promotes fork movement past G-quadruplex motifs to prevent DNA damage. BMC Biol, 12:101, . (PMID: 25471935, PMCID: PMC4275981)

Di Domenico, E. G. Mattarocci, S. Cimino-Reale, G. Parisi, P. Cifani, N. D'Ambrosio, E. Zakian, V. A. Ascenzioni, F. Tel1 and Rad51 are involved in the maintenance of telomeres with capping deficiency. Nucleic Acids Res, 41:6490-6500, . (PMID: 23677619, PMCID: PMC3711455)

Webb, C. J. Wu, Y. Zakian, V. A. DNA repair at telomeres: keeping the ends intact. Cold Spring Harb Perspect Biol, 5:, . (PMID: 23732473, PMCID: PMC3660827)

Paeschke, K. Bochman, M. L. Garcia, P. D. Cejka, P. Friedman, K. L. Kowalczykowski, S. C. Zakian, V. A. Pif1 family helicases suppress genome instability at G-quadruplex motifs. Nature, 497:458-462, . (PMID: 23657261, PMCID: PMC3680789)

Wu, Y. Dimaggio, P. A. Perlman, D. H. Zakian, V. Garcia, B. A. Novel phosphorylation sites in the S. cerevisiae Cdc13 protein reveal new targets for telomere length regulation. J Proteome Res, 12:316-327, . (PMID: 23181431, PMCID: PMC3739059)

Bochman, M. L. Paeschke, K. Zakian, V. A. DNA secondary structures: stability and function of G-quadruplex structures. Nat Rev Genet, 13:770-780, . (PMID: 23032257, PMCID: PMC3725559)

Wellinger, R. J. Zakian, V. A. Everything You Ever Wanted to Know About Saccharomyces cerevisiae Telomeres: Beginning to End. Genetics, 191:1073-1105, . (PMID: 22879408, PMCID: PMC3415994)

Zakian, V. A. Telomeres: the beginnings and ends of eukaryotic chromosomes. Exp Cell Res, 318:1456-1460, . (PMID: 22391099, PMCID: PMC3372703)

Sabouri, N. McDonald, K. R. Webb, C. J. Cristea, I. M. Zakian, V. A. DNA replication through hard-to-replicate sites, including both highly transcribed RNA Pol II and Pol III genes, requires the S. pombe Pfh1 helicase. Genes Dev, 26:581-593, . (PMID: 22426534, PMCID: PMC3315119)

Chisholm, K. M. Aubert, S. D. Freese, K. P. Zakian, V. A. King, M. C. Welcsh, P. L. A genomewide screen for suppressors of Alu-mediated rearrangements reveals a role for PIF1. PLoS One, 7:e30748, . (PMID: 22347400, PMCID: PMC3276492)

Webb, C. J. Zakian, V. A. Schizosaccharomyces pombe Ccq1 and TER1 bind the 14-3-3-like domain of Est1, which promotes and stabilizes telomerase-telomere association. Genes Dev, 26:82-91, . (PMID: 22215813, PMCID: PMC3258969)

Wu, Y. Zakian, V. A. The telomeric Cdc13 protein interacts directly with the telomerase subunit Est1 to bring it to telomeric DNA ends in vitro. Proc Natl Acad Sci U S A, 108:20362-20369, . (PMID: 21969561, PMCID: PMC3251085)

Bochman, M. L. Judge, C. P. Zakian, V. A. The Pif1 family in prokaryotes: what are our helicases doing in your bacteria? Mol Biol Cell, 22:1955-1959, . (PMID: 21670310, PMCID: PMC3113762)

Paeschke, K. Capra, J. A. Zakian, V. A. DNA replication through G-quadruplex motifs is promoted by the Saccharomyces cerevisiae Pif1 DNA helicase. Cell, 145:678-691, . (PMID: 21620135, PMCID: PMC3129610)

Tuzon, C. T. Wu, Y. Chan, A. Zakian, V. A. The Saccharomyces cerevisiae telomerase subunit Est3 binds telomeres in a cell cycle- and Est1-dependent manner and interacts directly with Est1 in vitro. PLoS Genet, 7:e1002060, . (PMID: 21573139, PMCID: PMC3088721)