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Virginia A. Zakian, PhD

Publications since 2011

Lin, K. W. Zakian, V. A. 21st Century Genetics: Mass Spectrometry of Yeast Telomerase. Cold Spring Harb Symp Quant Biol, In process, . (PMID: 26763982)

Webb, C. J. Zakian, V. A. Telomere les(i/s)ons from a telomerase RNA mutant. Cell Cycle, 14:3769-3770, . (PMID: 26697827)

Stundon, J. L. Zakian, V. A. Identification of Saccharomyces cerevisiae Genes Whose Deletion Causes Synthetic Effects in Cells with Reduced Levels of the Nuclear Pif1 DNA Helicase. G3 (Bethesda), In process, . (PMID: 26483010)

Webb, C. J. Zakian, V. A. Telomerase RNA stem terminus element affects template boundary element function, telomere sequence, and shelterin binding. Proc Natl Acad Sci U S A, In process, . (PMID: 26305931)

Phillips, J. A. Chan, A. Paeschke, K. Zakian, V. A. The pif1 helicase, a negative regulator of telomerase, acts preferentially at long telomeres. PLoS Genet, 11:e1005186, . (PMID: 25906395)

Lin, K. W. McDonald, K. R. Guise, A. J. Chan, A. Cristea, I. M. Zakian, V. A. Proteomics of yeast telomerase identified Cdc48-Npl4-Ufd1 and Ufd4 as regulators of Est1 and telomere length. Nat Commun, 6:8290, . (PMID: 26365526)

McDonald, K. R. Sabouri, N. Webb, C. J. Zakian, V. A. The Pif1 family helicase Pfh1 facilitates telomere replication and has an RPA-dependent role during telomere lengthening. DNA Repair (Amst), In process, . (PMID: 25303777)

Bochman, M. L. Paeschke, K. Chan, A. Zakian, V. A. Hrq1, a Homolog of the Human RecQ4 Helicase, Acts Catalytically and Structurally to Promote Genome Integrity. Cell Rep, 6:346-356, . (PMID: 24440721, PMCID: PMC3933191)

Zhou, R. Zhang, J. Bochman, M. L. Zakian, V. A. Ha, T. Periodic DNA patrolling underlies diverse functions of Pif1 on R-loops and G-rich DNA. Elife, 3:e02190, . (PMID: 24843019, PMCID: PMC3999857)

Sabouri, N. Capra, J. A. Zakian, V. A. The essential Schizosaccharomyces pombe Pfh1 DNA helicase promotes fork movement past G-quadruplex motifs to prevent DNA damage. BMC Biol, 12:101, . (PMID: 25471935, PMCID: PMC4275981)

Di Domenico, E. G. Mattarocci, S. Cimino-Reale, G. Parisi, P. Cifani, N. D'Ambrosio, E. Zakian, V. A. Ascenzioni, F. Tel1 and Rad51 are involved in the maintenance of telomeres with capping deficiency. Nucleic Acids Res, 41:6490-6500, . (PMID: 23677619, PMCID: PMC3711455)

Webb, C. J. Wu, Y. Zakian, V. A. DNA repair at telomeres: keeping the ends intact. Cold Spring Harb Perspect Biol, 5:, . (PMID: 23732473, PMCID: PMC3660827)

Paeschke, K. Bochman, M. L. Garcia, P. D. Cejka, P. Friedman, K. L. Kowalczykowski, S. C. Zakian, V. A. Pif1 family helicases suppress genome instability at G-quadruplex motifs. Nature, 497:458-462, . (PMID: 23657261, PMCID: PMC3680789)

Wu, Y. Dimaggio, P. A. Perlman, D. H. Zakian, V. Garcia, B. A. Novel phosphorylation sites in the S. cerevisiae Cdc13 protein reveal new targets for telomere length regulation. J Proteome Res, 12:316-327, . (PMID: 23181431, PMCID: PMC3739059)

Bochman, M. L. Paeschke, K. Zakian, V. A. DNA secondary structures: stability and function of G-quadruplex structures. Nat Rev Genet, 13:770-780, . (PMID: 23032257, PMCID: PMC3725559)

Wellinger, R. J. Zakian, V. A. Everything You Ever Wanted to Know About Saccharomyces cerevisiae Telomeres: Beginning to End. Genetics, 191:1073-1105, . (PMID: 22879408, PMCID: PMC3415994)

Zakian, V. A. Telomeres: the beginnings and ends of eukaryotic chromosomes. Exp Cell Res, 318:1456-1460, . (PMID: 22391099, PMCID: PMC3372703)

Sabouri, N. McDonald, K. R. Webb, C. J. Cristea, I. M. Zakian, V. A. DNA replication through hard-to-replicate sites, including both highly transcribed RNA Pol II and Pol III genes, requires the S. pombe Pfh1 helicase. Genes Dev, 26:581-593, . (PMID: 22426534, PMCID: PMC3315119)

Chisholm, K. M. Aubert, S. D. Freese, K. P. Zakian, V. A. King, M. C. Welcsh, P. L. A genomewide screen for suppressors of Alu-mediated rearrangements reveals a role for PIF1. PLoS One, 7:e30748, . (PMID: 22347400, PMCID: PMC3276492)

Webb, C. J. Zakian, V. A. Schizosaccharomyces pombe Ccq1 and TER1 bind the 14-3-3-like domain of Est1, which promotes and stabilizes telomerase-telomere association. Genes Dev, 26:82-91, . (PMID: 22215813, PMCID: PMC3258969)

Wu, Y. Zakian, V. A. The telomeric Cdc13 protein interacts directly with the telomerase subunit Est1 to bring it to telomeric DNA ends in vitro. Proc Natl Acad Sci U S A, 108:20362-20369, . (PMID: 21969561, PMCID: PMC3251085)

Bochman, M. L. Judge, C. P. Zakian, V. A. The Pif1 family in prokaryotes: what are our helicases doing in your bacteria? Mol Biol Cell, 22:1955-1959, . (PMID: 21670310, PMCID: PMC3113762)

Paeschke, K. Capra, J. A. Zakian, V. A. DNA replication through G-quadruplex motifs is promoted by the Saccharomyces cerevisiae Pif1 DNA helicase. Cell, 145:678-691, . (PMID: 21620135, PMCID: PMC3129610)

Tuzon, C. T. Wu, Y. Chan, A. Zakian, V. A. The Saccharomyces cerevisiae telomerase subunit Est3 binds telomeres in a cell cycle- and Est1-dependent manner and interacts directly with Est1 in vitro. PLoS Genet, 7:e1002060, . (PMID: 21573139, PMCID: PMC3088721)