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George P. Studzinski, MD, PhD

Publications since 2011

Pesakhov, S. Nachliely, M. Barvish, Z. Aqaqe, N. Schwartzman, B. Voronov, E. Sharoni, Y. Studzinski, G. P. Fishman, D. Danilenko, M. Cancer-selective cytotoxic Ca2+ overload in acute myeloid leukemia cells and attenuation of disease progression in mice by synergistically acting polyphenols curcumin and carnosic acid. Oncotarget, In process, . (PMID: 26870993)

Danilenko, M. Studzinski, G. P. Keep Harm at Bay: Oxidative Phosphorylation Induces Nrf2-Driven Antioxidant Response Via ERK5/MEF2/miR-23a Signaling to Keap-1. EBioMedicine, 3:4-5, . (PMID: 26870832, PMCID: PMC4739434)

Sarkar, S. Hewison, M. Studzinski, G. P. Li, Y. C. Kalia, V. Role of vitamin D in cytotoxic T lymphocyte immunity to pathogens and cancer. Crit Rev Clin Lab Sci, In process, . (PMID: 26479950)

Wang, X. Harrison, J. S. Studzinski, G. P. Enhancement of arabinocytosine (AraC) toxicity to AML cells by a differentiation agent combination. J Steroid Biochem Mol Biol, In process, . (PMID: 26319201)

Studzinski, G. P. Harrison, J. S. Wang, X. Sarkar, S. Kalia, V. Danilenko, M. Prospect: "Vitamin D Control of Hematopoietic Cell Differentiation and Leukemia" J Cell Biochem, In process, . (PMID: 25694395)

Gocek, E. Studzinski, G. P. The Potential of Vitamin D-Regulated Intracellular Signaling Pathways as Targets for Myeloid Leukemia Therapy. J Clin Med, 4:504-534, . (PMID: 26239344, PMCID: PMC4470153)

Yuzefpolskiy, Y. Baumann, F. M. Penny, L. A. Studzinski, G. P. Kalia, V. Sarkar, S. Vitamin D Receptor Signals Regulate Effector and Memory CD8 T Cell Responses to Infections in Mice. J Nutr, 144:2073-2082, . (PMID: 25320188)

Zheng, R. Wang, X. Studzinski, G. P. 1,25-Dihydroxyvitamin D3 induces monocytic differentiation of human myeloid leukemia cells by regulating C/EBPbeta expression through MEF2C. J Steroid Biochem Mol Biol, In process, . (PMID: 25448741)

Wang, X. Pesakhov, S. Harrison, J. S. Kafka, M. Danilenko, M. Studzinski, G. P. The MAPK ERK5, but not ERK1/2, inhibits the progression of monocytic phenotype to the functioning macrophage. Exp Cell Res, In process, . (PMID: 25447310)

Wang, X. Pesakhov, S. Weng, A. Kafka, M. Gocek, E. Nguyen, M. Harrison, J. S. Danilenko, M. Studzinski, G. P. ERK 5/MAPK PATHWAY HAS A MAJOR ROLE IN 1alpha,25-(OH) VITAMIN D-INDUCED TERMINAL DIFFERENTIATION OF MYELOID LEUKEMIA CELLS. J Steroid Biochem Mol Biol, 144 Pt A:223-227, . (PMID: 24514755, PMCID: PMC4000286)

Wang, X. Pesakhov, S. Harrison, J. S. Danilenko, M. Studzinski, G. P. ERK5 Pathway Regulates Transcription Factors Important for Monocytic Differentiation of Human Myeloid Leukemia Cells. J Cell Physiol, 229:856-867, . (PMID: 24264602)

Gocek, E. Moulas, A. N. Studzinski, G. P. Non-receptor protein tyrosine kinases signaling pathways in normal and cancer cells. Crit Rev Clin Lab Sci, 51:125-137, . (PMID: 24446827)

Chen-Deutsch, X. Kutner, A. Harrison, J. S. Studzinski, G. P. The pan-caspase inhibitor Q-VD-OPh has anti-leukemia effects and can interact with vitamin D analogs to increase HPK1 signaling in AML cells. Leuk Res, 36:884-888, . (PMID: 22541691, PMCID: PMC3361643)

Gocek, E. Studzinski, G. P. Genes encoding transcription factors have self-control: how important is this for cell differentiation? Leuk Res, 36:672-674, . (PMID: 22424711)

Halicka, H. D. Zhao, H. Li, J. Traganos, F. Studzinski, G. P. Darzynkiewicz, Z. Attenuation of constitutive DNA damage signaling by 1,25-dihydroxyvitamin D3. Aging (Albany NY), 4:270-278, . (PMID: 22498490, PMCID: PMC3371762)

Chen-Deutsch, X. Studzinski, G. P. Dual role of hematopoietic progenitor kinase 1 (HPK1) as a positive regulator of 1alpha,25-dihydroxyvitamin D-induced differentiation and cell cycle arrest of AML cells and as a mediator of vitamin D resistance. Cell Cycle, 11:1364-1373, . (PMID: 22421156, PMCID: PMC3350877)

Studzinski, G. P. Brown, G. Danilenko, M. Hughes, P. Marcinkowska, E. Differentiation and cell survival of myeloid leukemia cells. Leuk Res Treatment, 2012:370375, . (PMID: 23259065, PMCID: PMC3504243)

Duggal, J. Harrison, J. S. Studzinski, G. P. Wang, X. Involvement of MicroRNA181a in Differentiation and Cell Cycle Arrest Induced by a Plant-derived Antioxidant Carnosic Acid and Vitamin D Analog Doxercalciferol in Human Leukemia Cells. Microrna, 1:26-33, . (PMID: 25048087)

Gocek, E. Wang, X. Liu, X. Liu, C. G. Studzinski, G. P. MicroRNA-32 upregulation by 1,25-dihydroxyvitamin D3 in human myeloid leukemia cells leads to Bim targeting and inhibition of AraC-induced apoptosis. Cancer Res, 71:6230-6239, . (PMID: 21816906)

Wang, X. Studzinski, G. P. Oncoprotein Cot1 represses kinase suppressors of Ras1/2 and 1,25-dihydroxyvitamin D3-induced differentiation of human acute myeloid leukemia cells. J Cell Physiol, 226:1232-1240, . (PMID: 20945381, PMCID: PMC3440184)

Bobilev, I. Novik, V. Levi, I. Shpilberg, O. Levy, J. Sharoni, Y. Studzinski, G. P. Danilenko, M. The Nrf2 transcription factor is a positive regulator of myeloid Differentiation of acute myeloid leukemia cells. Cancer Biol Ther, 11:317-329, . (PMID: 21099366, PMCID: PMC3047086)

Zhang, J. Harrison, J. S. Studzinski, G. P. Isoforms of p38MAPK gamma and delta contribute to differentiation of human AML cells induced by 1,25-dihydroxyvitamin D(3). Exp Cell Res, 317:117-130, . (PMID: 20804750, PMCID: PMC2998239)