Mingzhu Fang, PhD
Selected from 37 peer-reviewed publications
1.Fang, M., Ohman-Strickland, P., McNeil, K., Lew, JP, Crabtree, B., Kipen, H., and Zarbl, H. (2015) Sleep Interruption Associated with House Staff Work Schedules Affects Circadian Gene Expression. Sleep Medicine (In Submission).
2.Fang, M.*, Zarbl, H. (2015) Enhancement of NAD+-dependent SIRT1 Deacetylase Activity by Methylselenocysteine Resets Mammary Epithelial Circadian Clock Disrupted by Carcinogen. * Corresponding author. Cancer Res (In Submission).
3.Zhu, H., Zhang, H., Fang, M., Yang, C.S., Fu, L., Pan, Z. (2014) Elevated Orai1 expression mediates tumor-promoting intracellular Ca2+ oscillations in human esophageal squamous cell carcinoma. Oncotarget. 5:3455-3471.
4.Fang, M., Zhang, X., and Zarbl, H. (2010) Methylselenocysteine Resets the Rhythmic Expression of Circadian and Growth Regulatory Genes Disrupted by Nitrosomethylurea in vivo. Cancer Prev Res. 3:640-52.
5.Fang, M., Chen D.P., and Yang, C.S. (2007) Dietary polyphenols may affect DNA methylation. J Nutrition, 131, 223S-228S.
6.Fang, M.Z., Chen, D., Sun, Y., Christman J.K., and Yang, C.S. (2005) Reversal of hypermethylation and reactivation of p16, RARβ, and MGMT genes by genistein and other isoflavones from soy. Clin. Cancer Res. 11: 7033-41.
7.Fang, M.Z.*, Wang, Y. *, Ai, N., Hou, Z., Sun, Y., Lu, H., Welsh, W., and Yang, C.S. (2003) The tea polyphenol epigallocatechin gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines. Cancer Res., 63: 7563-70 * contributed equally in this study.
8.Ren, X., Zhang, X., Kim, A.S., Mikheev, A.M., Fang, M., Sullivan, R., Bumgarner, R., Zarbl, H. (2008) Comparative genomics of susceptibility to mammary carcinogenesis among inbred rat strains: role of reduced prolactin signaling in resistance of the Copenhagen strain. Carcinogenesis, 29:177-85.
9.Yang, C.S., Fang, M., Lambert, J.D., Yan, P., and Huang, T.H. (2008) Reversal of hypermethylation and reactivation of genes by dietary polyphenolic compounds. Nutrition Reviews 66 (Suppl. 1): S18-S20.
10.Li, N., Sood, S., Wang, S., Fang, M., Wang, P., Sun, Z., Yang, C.S., Chen, X. (2005) Overexpression of 5-lipoxygenase and cyclooxygenase 2 in hamster and human oral cancer and chemopreventive effects of zileuton and celecoxib. Clin Cancer Res. 11:2089-96.
11.Fang, M.Z., Jin, Z., Wang, Y., Liao, J., Yang, G-Y, Wang, L-D, Yang, C.S. (2005) Promoter hypermethylation and inactivation of O6-methylguanine-DNA methyltransferase in esophageal squamous cell carcinomas and its reactivation in cell lines. Int. J. Oncol., 26:615-22.
12.Fang, M.Z., Liu, C., Song, Y., Yang, G-Y, Nie, Y., Liao, J., Zhao, X., Shimada, Y., Wang, L-D, and Yang, C.S. (2004) Overexpression of gastrin-releasing peptide (GRP) in human esophageal squamous cell carcinomas. Carcinogenesis, 25: 865-71.
13.Su, Y., Chen, X., Klein, M., Fang, M., Wang, S., Yang, C.S., Goyal, R.K. (2004) Phenotype of columnar-lined esophagus in rats with esophagogastroduodenal anastomosis: similarity to human Barrett's esophagus. Lab Invest. 84:753-65.
14.Wang, Y. *, Fang, M.Z.*, Liao, J., Yang, G-Y, Nie, Y., Song, Y., So, C., Xu, X., Wang, L.D., Yang, C.S. (2003) Hypermethylation associated inactivation of retinoic acid receptor beta (RARβ) in human esophageal squamous cell carcinoma. Clin. Cancer Res., 9: 5257-63. * contributed equally in this study.
15.Chen, X., Li, N., Wang, S., Hong, J., Fang, M., Yousselfson, J., Yang, P., Newman, R.A., Lubet, R.A., and Yang, C.S. (2002) Aberrant arachidonic acid metabolism in esophageal adenocarcinogenesis, and the effects of sulindac, nordihydroguaiaretic acid, and alpha-difluoromethylornithine on tumorigenesis in a rat surgical model. Carcinogenesis, 23(12): 2095-102
16.Fang, M.Z., Mar, W.C., and Cho, M.H. (2002) Cadmium affects genes involved in growth regulation during two-stage transformation of Balb/3T3 cells. Toxicology, 177: 253-265.
17.Fang, M.Z., Lee, H.W., and Cho, M.H. (2001) Improvement of in vitro two stage transformation model and detection of the promotional effect of cadmium. Toxicology In Vitro, 15:225-231
18.Fang, M.Z., Mar, W.C. and Cho, M.H. (2001) Cell cycle was disturbed in the MNNG-induced initiation stage during in vitro two-stage transformation of Balb/3T3 cells. Toxicology, 163: 175-84.
19.Fang, M.Z., Mar W.C., and Cho, M.H. (2001) Cadmium-induced alteration of connexin expression in the promotion stage of in vitro two-stage transformation. Toxicology, 161:117-127.
20.Fang, M.Z., Lee, M.H., Lee, Y.S., Kim, Y.C., Lee B.M., and Cho, M.H. (2001) Low expression of cyclin D2 in G2/M arrested and transformed Balb/3T3 cells. J. Vet. Med. Sci. 64: 201-205.
21.Fang, M.Z., Shin, M.K., Park, B.K., Kim, Y.S., Lee, J.W., and Cho, M.H. (2000) Analysis of urinary S-phenylmercapturic acid and trans-trans muconic acid for use as exposure biomarkers of benzene in petrochemical and industrial areas of Korea. Scandinavian Journal of Work, Environment and Health, 26(1): 62-66.
22.Fang, M.Z., Ahn, Y.C., Kim, M.Y., Kim, J.H., Son, J.W., Choi, J.H., Kim, J.S, Bae, M.O., Shin, M.K., Kim, W.H., Kweon, O.K., Lee, B.J., Jung, K.H., Kang, K.Y., Kim, C.H., Choi, S.J., Jang, K.S., Byun, J.H. and Cho, M.H. (2000) Effects of MBRI9901 (rhG-CSF) on ?-ray irradiated mice with bone marrow transplantation. Asia Pacific Journal of Pharmacology, 14:51-55.