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Leroy F. Liu, PhD

Selected Publications

Sui Zhang, Xiaobing Liu, Tasneem Bawa-Khalfe, Long-Sheng Lu, Yi Lisa Lyu, Leroy F. Liu, & Edward T.H. Yeh. Identification of the Molecular Basis of Doxorubicin-Induced Cardiotoxicity. Nature Medicine, in press (Oct. 2012 issue).

Wan S, Pestka S, Jubin RG, Lyu YL, Tsai Y-C, and Liu, L. F. (2012) Chemotherapeutics and Radiation Stimulate MHC Class I Expression through Elevated Interferon-beta Signaling in Breast Cancer Cells. PLoS ONE 7(3): e32542. doi:10.1371/journal.pone.0032542.

Desai, S. D, Reed, R. E. Burks, J., Wood, L. M., Pullikuth, A. K., Haas, A. L., and Liu, L. F., Breslin, J. B., Meiners S. and Sankar S. ISG15 disrupts cytoskeletal architecture and promotes motility in human breast cancer cells. Experimental Biol. and Medicine, 237:38-49 (2012).

Lin, R.-K., Zhou, N., Lyu, Y. L., Tsai, Y.-C., Lu, C.-H., Kerrigan, J., Chen, Y-C., Guan, Z., Hsieh, T.-H., and Liu, L. F. Dietary Isothiocyanates-Induced Apoptosis via Thiol Modification of DNA Topoisomerase IIa. J. Biol. Chem. 286:33591-600 (2011).

Tsai, Y.-C., Pestka, S. Lu-Hai Wang, L.-H. Runnels, L. Wan, S. and Liu, L. F., Interferon-b Autocrine Signaling Contributes to Oncogenic Ras Transformation. PLoS ONE, 6(8): e24291. doi:10.1371/journal.pone.0024291 (2011).

Wood, L. M., Sankar, S., Reed, R. E., Haas, A. L., Liu, L. F. McKinnon, P. and Desai, S. D. A Novel Role for ATM in Regulating Proteasome-Mediated Protein Degradation through Suppression of the ISG15 Conjugation Pathway. PLoS ONE, 6:16422 (2011).

Azarova, A. M., Lin, R.-K., Tsai, Y.-C, Liu, L. F., Lin, C.-P. and Lyu, Y. L. Genistein induces topoisomerase IIbeta- and proteasome-mediated DNA sequence rearrangements: Implications in infant leukemia, Biochem. Biophys. Res. Comm, 399:66-71 (2010).

Satyanarayana M, Kim YA, Rzuczek SG, Pilch DS, Liu AA, Liu, L.F, Rice JE, LaVoie EJ. Macrocyclic hexaoxazoles: Influence of aminoalkyl substituents on RNA and DNA G-quadruplex stabilization and cytotoxicity. Bioorg Med Chem Lett. 20:3150-3154 (2010).

Rzuczek SG, Pilch DS, Liu A, Liu L, Lavoie EJ, Rice JE Macrocyclic Pyridyl Polyoxazoles: Selective RNA and DNA G-Quadruplex Ligands as Antitumor Agents. J Med Chem, 53:3632-3644 (2010).

Lin, C. P., Ban, P., Lyu, Y. L. and Liu, L. F.  Proteasome-dependent processing of topoisomerase I-DNA adducts into DNA double-strand breaks at arrested replication forks. J. Biol. Chem. 284:28082-92 (2009).

Tsai YC, Qi H, Lin CP, Lin RK, Kerrigan JE, Rzuczek SG, Lavoie EJ, Rice JE, Pilch DS, Lyu YL, Liu L.F., A G-quadruplex stabilizer induces M phase cell cycle arrest. J. Biol. Chem. 284:22535-43 (2009).

Sharma L, Tsai YC, Liu AA, Liu L.F., LaVoie EJ. Cytotoxicity and TOP1-targeting activity of 8- and 9-amino derivatives of 5-butyl- and 5-(2-N,N-dimethylamino)ethyl-5H-dibenzo[c,h][1,6]naphthyridin-6-ones. Eur J Med Chem. 44:1471-6 (2009).

Feng W, Satyanarayana M, Tsai YC, Liu AA, Liu L.F., LaVoie EJ. Novel topoisomerase I-targeting antitumor agents synthesized from the N,N,N-trimethylammonium derivative of ARC-111, 5H-2,3-dimethoxy-8,9-methylenedioxy-5-[(2-N,N,N-trimethylammonium)ethyl]dibenzo[c,h][1,6]naphthyridin-6-one iodide. Eur J Med Chem. 44:3433-8 (2009).

Feng W, Satyanarayana M, Tsai YC, Liu AA, Liu L.F., LaVoie EJ. 12-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridines as novel topoisomerase I-targeting antitumor agents. Bioorg Med Chem. 17:2877-85 (2009)

Feng, W, Satyanarayana, M, Cheng, L, Liu, A, Tsai, YC, Liu, L. F. and Lavoie, E. J. Synthesis of N-substituted 5-[2-(N-alkylamino)ethyl]dibenzo[c,h][1,6]naphthyridines as novel topoisomerase I-targeting antitumor agents. Bioorg Med Chem. 16(20):9295-301. (2008).