Researcher Profile

Kim M. Hirshfield, MD, PhD

Assistant Professor of Medicine, Medical Oncology
Robert Wood Johnson Medical School
Rutgers, The State University of New Jersey

Rutgers Cancer Institute of New Jersey
195 Little Albany Street
New Brunswick, NJ 08901-1914

Phone: (732) 235-6028
Email: hirshfie@cinj.rutgers.edu

Assistant: Jacqueline Harris
(732) 235-7428
Email: jacqueline.harris@rutgers.edu

Resident Member, Rutgers Cancer Institute of New Jersey


Research Program Alignment

Membership Type: Associate I


Research Interests

  • Breast Cancer
  • Genetics
  • Molecular Epidemiology
  • Outcomes Studies
  • Prognostic/Predictive Markers

Selected Publications

Hirshfield KM, Toptygin D, Packard BZ, and Brand L. Dynamic fluorescence measurements of two-state systems: Applications to calcium-chelating probes. Analytical Biochemistry 1993; 209: 209-218. (PMID 8470792)

Hirshfield KM, Flannery R, and Daie J. Cotyledon cell number and cell size in relation to seed size and seed yield in soybean. Plant Physiology & Biochemistry 1993; 31:395-400.

Hirshfield KM, Toptygin D, Packard BZ, and Brand L. Steady-state fluorescence and time-resolved fluorescence measurements for studying molecular interactions. Journal of Biophysical Chemistry 1996; 62:25-38. (PMID: 8962469)

Hirshfield KM, Toptygin D, Grandhige G, and Brand L. A nanosecond fluorescence study of the simultaneous influx of calcium and cadmium into liposomes. Biophysical Chemistry 1998; 71:63-72. (PMID 9591360)

Harris SL, Gil G, Robins H, Hu W, Hirshfield K, Bond E, Bond G, Levine AJ. Detection of functional single nucleotide polymorphisms that affect apoptosis. Proc Natl Acad Sci. 2005; 102:16297-302. (PMID 16260726)

Harris SL, Gil G, Hu W, Robins H, Bond E, Hirshfield K, Feng Z, Yu X, Teresky AK, Bond G, Levine AJ. Single Nucleotide Polymorphisms in the p53 pathway, in Molecular Approaches to Controlling Cancer, Cold Spring Harbor Symposia on Quantitative Biology (editors: B Stillman and D Stewart), 2005; Vol. LXX, pp.111-9. (PMID 16869744)

Bond* G, Hirshfield* KM, Kirchhoff T, Alexe G, Bond EE, Robins H, Bartel F, Taubert H, Wuerl P, Hait W, Toppmeyer D, Offit K, and Levine A. MDM2 SNP309 accelerates tumor formation in a gender-specific and hormone-dependent manner. Cancer Research, 2006; 66: 5104-5110. * denotes equal contribution by authors (PMID 16707433)

Hirshfield, KM. Personalizing medicine through targeted agents, capitalizing on pathway dysregulation and biomarker use. Personalized Medicine, 2008, 5:575-577. Invited article

Kulkarni DA, Vazquez A, Haffty BG, Bandera EV, Hu W, Sun YY, Toppmeyer DL, Levine AJ, Hirshfield KM. A polymorphic variant in human MDM4 associates with accelerated age of onset of estrogen receptor negative breast cancer. Carcinogenesis 2009, 30: 1910-5. (PMID 19762336)

Hirshfield KM, Rebbeck TR, Levine AJ. Germline Mutations and Polymorphisms in the Origins of Cancers in Women Journal of Oncology 2010, 2010: 297671. (PMID: 20111735) Invited review

Haffty BG, Goyal S, Green C, Schiff D, Yang Q, Moran MS, Kulkarni D, Ganesan S, Hirshfield KM. Evaluation Of Single Nucleotide Polymorphisms (SNP) In The P53 Binding Protein Gene (TP53BP1), In Breast Cancer Patients Treated With Breast Conserving Surgery And Whole Breast Irradiation (BCS+RT). International Journal of Radiation Oncology, Biology, Biophysics 2011, 80: 385-391.

Das KM, Kong Y, Bajpai M, Kulkarni D, Geng X, Mishra P, Banerjee D, Hirshfield, KM. Transformation of benign Barrett’s epithelium by repeated acid and bile exposure over 65 weeks: A novel in-vitro model. International Journal of Cancer 2010, 128:274-82. (PMID: 20309934)

Rao M, Goyal  S, Khan A, Moran M, Hirshfield K, Ganesan S, Haffty BG. Clinicopathologic Presentation of Asian-Indian American (AIA) Women with Stage 0, I & II Breast Cancer, Journal of Immigrant and Minority Health 2010, 13:42-8. (PMID: 20563645)

 Mehta MS, Vazquez A, Kulkarni DA, Kerrigan JE, Atwal G, Metsugi S, Toppmeyer DL, Levine AJ, Hirshfield KM. Polymorphic variants in TSC1 and TSC2 and their association with breast cancer phenotypes. Breast Cancer Research and Treatment 2010, 125:861-8. (PMID: 20658316)

Vazquez A, Kulkarni D, Grochola LF, Bond GL, Barnard N, Toppmeyer DL, Levine AJ, Hirshfield KM. A genetic variant in a PP2A regulatory subunit encoded by the PPP2R2B gene associates with altered breast cancer risk and recurrence. International J Cancer 2011,128:2335-43. (PMID: 20669227)

The content for this Research Profile is maintained by Paul Novembre (novembre@cinj.rutgers.edu)