Researcher Profile

Li Cai, PhD

Associate Professor of Biomedical Engineering
School of Engineering
Rutgers, The State University of New Jersey

Biomedical Engineering Building
599 Taylor Road, Room 208
Piscataway, NJ 08854

Phone: (848) 445-6559

Research Program Alignment

Membership Type: Associate - CCSG

Research Interests

  • Genetic mechanisms that regulate gene expression of stem cells in both normal development and tumorigenesis

Selected Publications

Cai L, Hayes NL, and Nowakowski RS, Local homogeneity of cell cycle length in developing mouse cortex. J Neurosci, 1997. 17(6): p. 2079-87.

Cai L, Hayes NL, and Nowakowski RS, Synchrony of clonal cell proliferation and contiguity of clonally related cells: production of mosaicism in the ventricular zone of developing mouse neocortex. J Neurosci, 1997. 17(6): p. 2088-100.

Cai L, Morrow EM, and Cepko CL, Misexpression of basic helix-loop-helix genes in the murine cerebral cortex affects cell fate choices and neuronal survival. Development, 2000. 127(14): p. 3021-30.

Lin JC, Cai L, and Cepko CL, The external granule layer of the developing chick cerebellum generates granule cells and cells of the isthmus and rostral hindbrain. J Neurosci, 2001. 21(1): p. 159-68.

Lu QR, Cai L, Rowitch D, Cepko CL, and Stiles CD, Ectopic expression of Olig1 promotes oligodendrocyte formation and reduces neuronal survival in developing mouse cortex. Nat Neurosci, 2001. 4(10): 973-4.

Cai L, Hayes NL, Takahashi T, Caviness VS, Jr., and Nowakowski RS, Size distribution of retrovirally marked lineages matches prediction from population measurements of cell cycle behavior. J Neurosci Res, 2002. 69(6): p. 731-44.

Goh KL, Cai L, Cepko CL, and Gertler FB, Ena/VASP proteins regulate cortical neuronal positioning. Curr Biol, 2002. 12(7): p. 565-9.

Allinen M, Beroukhim R, Cai L, Brennan C, Lahti-Domenici J, Huang H, Porter D, Hu M, Chin L, Richardson A, Schnitt S, Sellers WR, and Polyak K, Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell, 2004. 6(1): p. 17-32.

Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, and Cepko CL, Genomic analysis of mouse retinal development. PLoS Biol, 2004. 2(9): p. E247.

Cai L, Huang H, Blackshaw S, Liu JS, Cepko C, and Wong WH, Clustering analysis of SAGE data using a Poisson approach. Genome Biol, 2004. 5(7): p. R51.

Hu M, Yao J, Cai L, Bachman KE, van den Brule F, Velculescu V, and Polyak K, Distinct epigenetic changes in the stromal cells of breast cancers. Nat Genet, 2005. 37(8): p. 899-905.

Lepourcelet M, Tou L, Cai L, Sawada J, Lazar AJ, Glickman JN, Williamson JA, Everett AD, Redston M, Fox EA, Nakatani Y, and Shivdasani RA, Insights into developmental mechanisms and cancers in the mammalian intestine derived from serial analysis of gene expression and study of the hepatoma-derived growth factor (HDGF). Development, 2005. 132(2): p. 415-27.

Lyu YL, Lin CP, Azarova AM, Cai L, Wang JC, and Liu LF, Role of topoisomerase IIbeta in the expression of developmentally regulated genes. Mol Cell Biol, 2006. 26(21): p. 7929-41.

Doh ST, Zhang Y, Temple MH, and Cai L, Non-coding sequence retrieval system for comparative genomic analysis of gene regulatory elements. BMC Bioinformatics, 2007. 8: p. 94.

Hars ES, Qi H, Ryazanov AG, Jin S, Cai L, Hu C, and Liu LF, Autophagy regulates ageing in C. elegans. Autophagy, 2007. 3(2): p. 93-5.

The content for this Research Profile is maintained by Paul Novembre (