Biomedical Engineering Building
599 Taylor Road
Piscataway, NJ 08854
Developing novel, minimally invasive optical technology to track signaling pathways and analyze function of genes w/i living cells (quantifying in tumorigenic cells, structural alterations resulting from abnormal expression of pro- or anti-apoptotic proteins/abnormal mechanisms of cell death)
Characterizing the relationship between physical and morphological phenotypes and patterns of gene expression during early cancer development
N.N. Boustany, M.L. Gray, A.C. Black, E.B. Hunziker, “Time-dependent changes in the response of cartilage to static compression suggest interstitial pH is not the only signaling mechanism”, J. Orthop. Res.,13(5): 740-750 (1995).
N.N. Boustany, J.M. Crawford, R. Manoharan, R. Dasari, M.S. Feld, “Analysis of nucleotides and aromatic amino acids in normal and neoplastic colon mucosa by ultraviolet resonance Raman spectroscopy”, Laboratory Investigation, 79(10): 1201-1214 (1999).
N.N. Boustany, R. Drezek, N.V. Thakor, “Calcium-induced alterations in mitochondrial morphology quantified in situ with Optical Scatter Imaging”, Biophysical J., 83: 1691-1700 (2002). PMID: 12202392
N.N. Boustany and N.V. Thakor, “Light Scatter Spectroscopy and Imaging of Cellular and Subcellular Events” in Biomedical Photonics Handbook, Editor: Tuan Vo-Dinh, Ph.D., CRC press, Boca Raton, FL, p. 16.1-16.23, (2003).
N.N. Boustany, Y.C. Tsai, G.A. Oyler, B. Pfister, W.M. Joiner, N.V. Thakor, “Bcl-xL-dependent light scattering by apoptotic cells”, Biophysical J., 87 (6): 4163-4171 (2004). PMID: 15377529
J. Zheng, Y.C. Tsai, P. Kadimcherla, R. Zhang, J. Shi, G.A. Oyler, N.N. Boustany, “The C-terminaltransmembrane domain of BCL-xL mediates changes in mitochondrial morphology”, Biophysical J., 94 (1): 286-297 (2008). PMID: 17766334
R. Pasternack, Z. Qian, J. Zheng, D.N. Metaxas, E. White, N.N. Boustany, “ Measurement of Subcellular Texture by Optical Gabor-Like Filtering with a Digitial Micromirror Device”, Optics Letters,33(19),2209-2211 (2008). Erratum in: Opt Lett. 2009 Jul 1;34(13):1939. PMID: 18830354
R. Pasternack, Z. Qian, J. Zheng, D.N. Metaxas, N.N. Boustany, “Highly Sensitive size discrimination of submicron objects using optical Fourier filtering based on 2D Gabor filters”, Optics Express, 17(14), 12001-12012 (2009). PMID: 19582115
N.N. Boustany, R.M. Pasternack, J-Y. Zheng “Optical scatter microscopy based on two-dimensional Gabor filters”, Journal of Visualized Experiments,http://www.jove.com/index/details.stp?id=1915, Jun 2;(40), pii: 1915 (2010). PMID: 20526280
N.N. Boustany, S.A. Boppart, V. Backman, “Microscopic Imaging and Spectroscopy with Scattered Light”, Annual Review of Biomedical Engineering, 12:285-314.(2010). PMID: 20617940
R.M. Pasternack, J-Y. Zheng, N.N. Boustany, “Optical Scatter Changes at the Onset of Apoptosis Are Spatially Associated with Mitochondria”, Journal of Biomedical Optics Letters. 5(4):040504. (2010). PMID: 20799771
J-Y. Zheng and N.N. Boustany, “Alterations in the characteristic size distributions of subcellular scatterers at the onset of apoptosis: Effect of Bcl-xL and Bax/Bak”, J. Biomedical Optics, 15(4):045002 (2010). PMID: 20799797
R.M. Pasternack, J-Y. Zheng, N.N. Boustany, “Detection of mitochondrial fission with orientation-dependent optical Fourier filters”, Cytometry Part A. 79A: 137-148 (2011).PMID: 21265007