Researcher Profile

Peter Lobel, PhD

Resident Member, Center for Advanced Biotechnology and Medicine; Executive Director, CABM/RWJMS/Rutgers Biological Mass Spectrometry Resource/Facility
Professor of Pharmacology
Robert Wood Johnson Medical School
Rutgers, The State University of New Jersey

Center for Advanced Biotechnology and Medicine
679 Hoes Lane West, Room 204
Piscataway, NJ 08854

Phone: (732) 235-5032

Assistant: Elaine Simpson
(732) 235-5778


Research Program Alignment

Membership Type: Full

Research Interests

  • Lysosome biology and disease
  • Proteomics.

Selected Publications

Sleat DE, Ding L, Wang S, Zhao C, Wang Y, Xin W, Zheng H, Moore DF, Sims KB, Lobel P. Mass spectrometry-based protein profiling to determine the cause of lysosomal storage diseases of unknown etiology. Mol Cell Proteomics. 2009; 8:1708-18

Guhaniyogi J, Sohar I, Das K, Stock AM, Lobel P. Crystal structure and autoactivation pathway of the precursor form of human tripeptidyl-peptidase 1, the enzyme deficient in late infantile ceroid lipofuscinosis. J Biol Chem. 2009; 284:3985-97.

Sun P, Sleat DE, Lecocq M, Hayman AR, Jadot M, Lobel P. Acid phosphatase 5 is responsible for removing the mannose 6-phosphate recognition marker from lysosomal proteins. Proc Natl Acad Sci USA. 2008; 105:16590-5.

Sleat DE, Della Valle MC, Zheng H, Moore DF, Lobel P. The mannose 6-phosphate glycoprotein proteome. J Proteome Res. 2008; 7:3010-21.

Naureckiene S, Sleat DE, Lackland H, Fensom A, Vanier MT, Wattiaux R, Jadot M, Lobel P. Identification of HE1 as the second gene of Niemann-Pick C disease. Science. 2000; 290:2298-301.

Sleat DE, Donnelly RJ, Lackland H, Liu CG, Sohar I, Pullarkat RK, Lobel P. Association of mutations in a lysosomal protein with classical late-infantile neuronal ceroid lipofuscinosis. Science. 1997; 277:1802-5.

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