Researcher Profile

Gaetano T. Montelione, PhD

Full Member, Cancer Pharmacology Program

Member since 1995

Academic Appointment

Distinguished Professor of Molecular Biology and Biochemistry
School of Arts and Sciences
Rutgers, The State University of New Jersey


Jerome and Lorraine Aresty Chair in Cancer Biology Research; Director, Northeast Structural Genomics Consortium; Adjunct Professor of Biochemistry, Robert Wood Johnson Medical School


Research Interests

  • Prof. Montelione's primary expertise is in protein biochemistry and NMR spectroscopy.
  • He served as Director of the Northeast Structural Genomics Consortium (NESG) (2000-2016), which developed a successful high-throughput pipeline for protein sample and 3D structure production. The NESG program involved extensive efforts in new technology development for protein sample production, NMR, X-ray crystallography, and structural bioinformatics, and resulted in more than 350 peer reviewed publications. More than 1,300 structures were determined by the NESG team using crystallography and NMR.
  • Montelione trained in experimental and theoretical physical chemistry at Cornell University, under the joint supervision of Prof. H. A. Scheraga (Cornell) and Prof. K. Wüthrich (ETH Zurich). With Prof. G. Wagner (Michigan) he carried out research on NMR pulse sequence development, including the design and implementation of the first triple-resonance protein NMR experiments.
  • The particular strengths of the Montelione laboratory include development of computational NMR methods and software for analysis of protein structures and dynamics. They also have lead a few dozen crystallography projects, and integrative projects combining NMR, crystallography, SAXS, and molecular modeling.
  • The biomedical focus areas of the lab include structure-function studies of protein complexes involved in cancer biology, innate immune response, and influenza virus infection. The group has extensive expertise in protein expression in E. coli, yeast, and mammalian systems, and in production of membrane proteins.
  • Montelione is also a member of several academic and commercial structural biology advisory groups, co-chair of the international wwPDB Task Force on NMR Structure Validation, and Foreign Expert Advisor to Jiangnan University (Wuxi, China).

Selected Publications

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