Targeted Genomic Analysis of Human Cancers

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Targeted Genomic Analysis of Human Cancers

The purpose of this study is to identify potentially "actionable" genomic alterations in cancers using next-generation sequencing technology, with a focus on rare cancers and cancers for which there is limited standard therapy. The overall hypothesis of this protocol is that actionable mutations are present in a significant subset of patients with cancers for which there is no effective curative therapy. To test this hypothesis, the aims of this study are as follows:

1.1. To obtain blood and tumor tissue for next-generation sequencing and determine the frequency of finding genomic alterations for which there are clinically available (commercially or research based) targeted therapies. Treating clinicians will be provided with relevant validated mutation data for treatment or referral of the patient to pertinent studies.
1.2. To collect clinical outcomes of patients for which sequencing has been performed.
1.3. To obtain whole tumor genome data for data storage and future computational analysis and correlation with clinical data.
1.4. To obtain tumor tissue for development of future in vitro and in vivo cancer models.

Protocol Number: 001209
Phase: NA
Applicable Disease Sites: Any Site
Drugs Involved:
Principal Investigator: Shridar Ganesan
Research Nurse: Michelle Orlick
Scope: National
Therapies Involved:
Participating Institutions: Ocean Medical Center
Rutgers Cancer Institute of New Jersey
Riverview Medical Center
Morristown Medical Center
Jersey Shore University Medical Center
Overlook Medical Center
Southern Ocean Medical Center
Bayshore Community Hospital

For further information on this clinical trial, please contact us at 732-235-8675 or


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