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Comprehensive Genomics

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Co-Directors: Shridar Ganesan, MD, PhD and Andrew Brooks, PhD

Manager: Curtis Krier

The Comprehensive Genomics shared resource (Genomics) of Rutgers Cancer Institute of New Jersey is an institutionally managed shared resource whose purpose is to provide centralized, high quality, cost-effective cutting-edge genomic analyses of cells and tissues.

This shared resource has been greatly expanded over the last grant period and now resides within the Rutgers University Cell and DNA Repository (RUCDR Infinite Biologics) and includes a large suite of next-generation sequencing technologies.

Comprehensive Genomics Team

Under the leadership of Drs. Shridar Ganesan and Andrew Brooks, Genomics:

  • Provides investigators with integrative consultation on experimental design, bioinformatics, and data analysis prior to initiation of experiments, in collaboration with the Bioinformatics shared resource;
  • Performs sample preparation, including nucleic acid extraction from a wide variety of biological samples, library preparation, and target enrichment as needed;
  • Provides next-generation sequencing of a wide range of biological samples utilizing current platforms, including Illumina HiSeq; this includes DNA sequencing (targeted sequencing, whole exome sequencing, whole genome sequencing) and RNA sequencing;
  • Provides Clinical Laboratory Improvement Amendments (CLIA)-certified panel sequencing of cancer-related genes on clinical cancer specimens;
  • Provides DNA methylation analysis and sequencing, and support for CHIP-Seq and similar analyses;
  • Provides custom RNA analysis using flexible platforms such as RT-PCR, micro-droplet PCR, single-cell sequencing, and microarray;
  • Provides data storage and seamless data transfer to investigators;
  • Provides a range of services from single tasks, to comprehensive workflows depending on needs and experience of individual investigators; and
  • Organizes educational sessions and workshops designed to disseminate knowledge of and access to the technologies available through the shared resource.

By providing cutting-edge genomic services, the Comprehensive Genomics shared resource is helping Rutgers Cancer Institute members drive innovative and impactful molecular and genomic analyses of cell and animal-based model systems and human cancer samples.

 

ACKNOWLEDGEMENT OF COMPREHENSIVE GENOMICS SHARED RESOURCE

The Comprehensive Genomics shared resource of Rutgers Cancer Institute of New Jersey is a specialized service facility that supports the cancer research efforts of our members.

This facility is supported primarily by the Cancer Center Support Grant (CCSG) from the National Cancer Institute.  Additional support may be provided from other sources, such as chargeback systems, institutional funding and/or other grants. The support from the CCSG allows the facility to provide benefits to Cancer Center members, such as ensured access to services or subsidies to user rates.

Please remember to acknowledge the valuable services provided by the Comprehensive Genomics shared resource in your research papers, publications, and grant applications. The following acknowledgement statement is recommended:

"This research was supported by the Comprehensive Genomics shared resource of Rutgers Cancer Institute of New Jersey (P30CA072720)."

(Note: please also consider including the names of individuals from the shared resource if they provided any intellectual input or additional effort.)

 

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