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Yibin Kang, PhD

Publications since 2011

Kang, Y. Dissecting Tumor-Stromal Interactions in Breast Cancer Bone Metastasis. Endocrinol Metab (Seoul), In process, . (PMID: 27184014)

Celia-Terrassa, T. Kang, Y. Distinctive properties of metastasis-initiating cells. Genes Dev, 30:892-908, . (PMID: 27083997)

Alesi, G. N. Jin, L. Li, D. Magliocca, K. R. Kang, Y. Chen, Z. G. Shin, D. M. Khuri, F. R. Kang, S. RSK2 signals through stathmin to promote microtubule dynamics and tumor metastasis. Oncogene, In process, . (PMID: 27041561)

Li, Z. Kang, Y. Emerging therapeutic targets in metastatic progression: a focus on breast cancer. Pharmacol Ther, In process, . (PMID: 27000769)

Hu, J. Y. Yi, W. Zhang, M. Y. Xu, R. Zeng, L. S. Long, X. R. Zhou, X. M. Zheng, X. S. Kang, Y. Wang, H. Y. MicroRNA-711 is a prognostic factor for poor overall survival and has an oncogenic role in breast cancer. Oncol Lett, 11:2155-2163, . (PMID: 26998141, PMCID: PMC4774458)

Zhao, P. Xu, Y. Wei, Y. Qiu, Q. Chew, T. L. Kang, Y. Cheng, C. The CD44s splice isoform is a central mediator for invadopodia activity. J Cell Sci, In process, . (PMID: 26869223)

Li, W. Kang, Y. Probing the Fifty Shades of EMT in Metastasis. Trends Cancer, 2:65-67, . (PMID: 27042694, PMCID: PMC4815261)

Kang, Y. Imaging TGFbeta Signaling in Mouse Models of Cancer Metastasis. Methods Mol Biol, 1344:219-232, . (PMID: 26520127)

Bednarz-Knoll, N. Efstathiou, A. Gotzhein, F. Wikman, H. Mueller, V. Kang, Y. Pantel, K. Potential Involvement of Jagged1 in Metastatic Progression of Human Breast Carcinomas. Clin Chem, In process, . (PMID: 26721293)

Hoshino, A. Costa-Silva, B. Shen, T. L. Rodrigues, G. Hashimoto, A. Tesic Mark, M. Molina, H. Kohsaka, S. Di Giannatale, A. Ceder, S. Singh, S. Williams, C. Soplop, N. Uryu, K. Pharmer, L. King, T. Bojmar, L. Davies, A. E. Ararso, Y. Zhang, T. Zhang, H. Hernandez, J. Weiss, J. M. Dumont-Cole, V. D. Kramer, K. Wexler, L. H. Narendran, A. Schwartz, G. K. Healey, J. H. Sandstrom, P. Jorgen Labori, K. Kure, E. H. Grandgenett, P. M. Hollingsworth, M. A. de Sousa, M. Kaur, S. Jain, M. Mallya, K. Batra, S. K. Jarnagin, W. R. Brady, M. S. Fodstad, O. Muller, V. Pantel, K. Minn, A. J. Bissell, M. J. Garcia, B. A. Kang, Y. Rajasekhar, V. K. Ghajar, C. M. Matei, I. Peinado, H. Bromberg, J. Lyden, D. Tumour exosome integrins determine organotropic metastasis. Nature, 527:329-335, . (PMID: 26524530)

Aleckovic, M. Kang, Y. Welcoming Treat: Astrocyte-Derived Exosomes Induce PTEN Suppression to Foster Brain Metastasis. Cancer Cell, 28:554-556, . (PMID: 26555172)

Esposito, M. Kang, Y. RAI2: Linking Retinoic Acid Signaling with Metastasis Suppression. Cancer Discov, 5:466-468, . (PMID: 25941336, PMCID: PMC4422076)

Zheng, H. Kang, Y. Cradle of evil: osteogenic niche for early bone metastasis. Cancer Cell, 27:153-155, . (PMID: 25670074)

Wong, K. K. Li, W. An, Y. Duan, Y. Li, Z. Kang, Y. Yan, Y. beta-Spectrin regulates the Hippo signaling pathway and modulates the basal actin network. J Biol Chem, In process, . (PMID: 25589787)

Chakrabarti, R. Kang, Y. Transplantable mouse tumor models of breast cancer metastasis. Methods Mol Biol, 1267:367-380, . (PMID: 25636479)

Aleckovic, M. Kang, Y. Bone marrow stroma-derived miRNAs as regulators, biomarkers and therapeutic targets of bone metastasis. Bonekey Rep, 4:671, . (PMID: 25908970)

Mathias, R. A. Greco, T. M. Oberstein, A. Budayeva, H. G. Chakrabarti, R. Rowland, E. A. Kang, Y. Shenk, T. Cristea, I. M. Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity. Cell, 159:1615-1625, . (PMID: 25525879)

Aleckovic, M. Kang, Y. Regulation of cancer metastasis by cell-free miRNAs. Biochim Biophys Acta, In process, . (PMID: 25450578)

Chakrabarti, R. Wei, Y. Hwang, J. Hang, X. Andres Blanco, M. Choudhury, A. Tiede, B. Romano, R. A. DeCoste, C. Mercatali, L. Ibrahim, T. Amadori, D. Kannan, N. Eaves, C. J. Sinha, S. Kang, Y. DeltaNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signalling. Nat Cell Biol, 16:1004-15, 1, . (PMID: 25241036, PMCID: PMC4183725)

Guo, F. Wan, L. Zheng, A. Stanevich, V. Wei, Y. Satyshur, K. A. Shen, M. Lee, W. Kang, Y. Xing, Y. Structural Insights into the Tumor-Promoting Function of the MTDH-SND1 Complex. Cell Rep, 8:1704-1713, . (PMID: 25242325)

Wan, L. Hu, G. Wei, Y. Yuan, M. Bronson, R. T. Yang, Q. Siddiqui, J. Pienta, K. J. Kang, Y. Genetic Ablation of Metadherin Inhibits Autochthonous Prostate Cancer Progression and Metastasis. Cancer Res, 74:5336-5347, . (PMID: 25074613, PMCID: PMC4167565)

Zheng, H. Shen, M. Zha, Y. L. Li, W. Wei, Y. Blanco, M. A. Ren, G. Zhou, T. Storz, P. Wang, H. Y. Kang, Y. PKD1 Phosphorylation-Dependent Degradation of SNAIL by SCF-FBXO11 Regulates Epithelial-Mesenchymal Transition and Metastasis. Cancer Cell, 26:358-373, . (PMID: 25203322, PMCID: PMC4159622)

Cicchini, M. Chakrabarti, R. Kongara, S. Price, S. Nahar, R. Lozy, F. Zhong, H. Vazquez, A. Kang, Y. Karantza, V. Autophagy regulator BECN1 suppresses mammary tumorigenesis driven by WNT1 activation and following parity. Autophagy, In process, . (PMID: 25180518)

Cicchini, M. Chakrabarti, R. Kongara, S. Price, S. Nahar, R. Lozy, F. Zhong, H. Vazquez, A. Kang, Y. Karantza, V. Autophagy regulator BECN1 suppresses mammary tumorigenesis driven by WNT1 activation and following parity. Autophagy, In process, . (PMID: 25483966)

Ell, B. Qiu, Q. Wei, Y. Mercatali, L. Ibrahim, T. Amadori, D. Kang, Y. The miRNA-23b/27b/24 Cluster Promotes Breast Cancer Lung Metastasis by Targeting Metastasis-Suppressive Gene Prosaposin. J Biol Chem, 289:21888-21895, . (PMID: 24966325, PMCID: PMC4139207)

Wan, L. Lu, X. Yuan, S. Wei, Y. Guo, F. Shen, M. Yuan, M. Chakrabarti, R. Hua, Y. Smith, H. A. Blanco, M. A. Chekmareva, M. Wu, H. Bronson, R. T. Haffty, B. G. Xing, Y. Kang, Y. MTDH-SND1 Interaction Is Crucial for Expansion and Activity of Tumor-Initiating Cells in Diverse Oncogene- and Carcinogen-Induced Mammary Tumors. Cancer Cell, 26:92-105, . (PMID: 24981741, PMCID: PMC4101059)

Li, W. Kang, Y. A New Lnc in Metastasis: Long Noncoding RNA Mediates the ProMetastatic Functions of TGF-beta. Cancer Cell, 25:557-559, . (PMID: 24823634, PMCID: PMC4091806)

Wang, Y. Lei, R. Zhuang, X. Zhang, N. Pan, H. Li, G. Hu, J. Pan, X. Tao, Q. Fu, D. Xiao, J. Chin, Y. E. Kang, Y. Yang, Q. Hu, G. DLC1-dependent parathyroid hormone-like hormone inhibition suppresses breast cancer bone metastasis. J Clin Invest, 124:1646-1659, . (PMID: 24590291, PMCID: PMC3973085)

Fan, J. Shan, C. Kang, H. B. Elf, S. Xie, J. Tucker, M. Gu, T. L. Aguiar, M. Lonning, S. Chen, H. Mohammadi, M. Britton, L. M. Garcia, B. A. Aleckovic, M. Kang, Y. Kaluz, S. Devi, N. Van Meir, E. G. Hitosugi, T. Seo, J. H. Lonial, S. Gaddh, M. Arellano, M. Khoury, H. J. Khuri, F. R. Boggon, T. J. Kang, S. Chen, J. Tyr Phosphorylation of PDP1 Toggles Recruitment between ACAT1 and SIRT3 to Regulate the Pyruvate Dehydrogenase Complex. Mol Cell, 53:534-548, . (PMID: 24486017, PMCID: PMC3943932)

Esposito, M. Kang, Y. Targeting tumor-stromal interactions in bone metastasis. Pharmacol Ther, 141:222-233, . (PMID: 24140083, PMCID: PMC3947254)

Ell, B. Kang, Y. MicroRNAs as regulators of bone homeostasis and bone metastasis. Bonekey Rep, 3:549, . (PMID: 25120906, PMCID: PMC4119205)

Goode, G. D. Ballard, B. R. Manning, H. C. Freeman, M. L. Kang, Y. Eltom, S. E. Knockdown of aberrantly upregulated aryl hydrocarbon receptor reduces tumor growth and metastasis of MDA-MB-231 human breast cancer cell line. Int J Cancer, 133:2769-2780, . (PMID: 23733406, PMCID: PMC3797219)

Ell, B. Kang, Y. MicroRNAs as regulators of tumor-associated stromal cells. Oncotarget, 4:2166-2167, . (PMID: 24293477, PMCID: PMC3926815)

Wan, L. Pantel, K. Kang, Y. Tumor metastasis: moving new biological insights into the clinic. Nat Med, 19:1450-1464, . (PMID: 24202397)

Ell, B. Mercatali, L. Ibrahim, T. Campbell, N. Schwarzenbach, H. Pantel, K. Amadori, D. Kang, Y. Tumor-Induced Osteoclast miRNA Changes as Regulators and Biomarkers of Osteolytic Bone Metastasis. Cancer Cell, 24:542-556, . (PMID: 24135284, PMCID: PMC3832956)

Alexia, C. Poalas, K. Carvalho, G. Zemirli, N. Dwyer, J. Dubois, S. M. Hatchi, E. M. Cordeiro, N. Smith, S. S. Castanier, C. Le Guelte, A. Wan, L. Kang, Y. Vazquez, A. Gavard, J. Arnoult, D. Bidere, N. The endoplasmic reticulum acts as a platform for ubiquitylated components of nuclear factor kappaB signaling. Sci Signal, 6:ra79, . (PMID: 24003256)

Smith, H. A. Kang, Y. Acute infection induces a metastatic niche: a double menace for cancer patients. Clin Cancer Res, 19:4547-4549, . (PMID: 23922303, PMCID: PMC3771332)

Deng, Y. Huang, Z. Xu, Y. Jin, J. Zhuo, W. Zhang, C. Zhang, X. Shen, M. Yan, X. Wang, L. Wang, X. Kang, Y. Si, J. Zhou, T. MiR-215 modulates gastric cancer cell proliferation by targeting RB1. Cancer Lett, In process, . (PMID: 23981575)

Ell, B. Kang, Y. Transcriptional control of cancer metastasis. Trends Cell Biol, In process, . (PMID: 23838335)

Lee, S. T. Feng, M. Wei, Y. Li, Z. Qiao, Y. Guan, P. Jiang, X. Wong, C. H. Huynh, K. Wang, J. Li, J. Karuturi, K. M. Tan, E. Y. Hoon, D. S. Kang, Y. Yu, Q. Protein tyrosine phosphatase UBASH3B is overexpressed in triple-negative breast cancer and promotes invasion and metastasis. Proc Natl Acad Sci U S A, 110:11121-11126, . (PMID: 23784775, PMCID: PMC3704014)

Kang, Y. Pantel, K. Tumor cell dissemination: emerging biological insights from animal models and cancer patients. Cancer Cell, 23:573-581, . (PMID: 23680145, PMCID: PMC3667710)

Zheng, H. Kang, Y. Multilayer control of the EMT master regulators. Oncogene, In process, . (PMID: 23604123)

Smith, H. A. Kang, Y. The metastasis-promoting roles of tumor-associated immune cells. J Mol Med (Berl), 91:411-429, . (PMID: 23515621, PMCID: PMC3697909)

Lee, J. Y. Park, M. K. Park, J. H. Lee, H. J. Shin, D. H. Kang, Y. Lee, C. H. Kong, G. Loss of the polycomb protein Mel-18 enhances the epithelial-mesenchymal transition by ZEB1 and ZEB2 expression through the downregulation of miR-205 in breast cancer. Oncogene, In process, . (PMID: 23474752)

Ren, G. Kang, Y. A one-two punch of miR-126/126* against metastasis. Nat Cell Biol, 15:231-233, . (PMID: 23449143)

DeGraff, D. J. Robinson, V. L. Shah, J. B. Brandt, W. D. Sonpavde, G. Kang, Y. Liebert, M. Wu, X. R. Taylor, J. A. 3rd Current preclinical models for the advancement of translational bladder cancer research. Mol Cancer Ther, 12:121-130, . (PMID: 23269072)

Wan, L. Kang, Y. Pleiotropic roles of AEG-1/MTDH/LYRIC in breast cancer. Adv Cancer Res, 120:113-134, . (PMID: 23889989)

Leroy, G. Dimaggio, P. A. Chan, E. Y. Zee, B. M. Blanco, M. A. Bryant, B. Flaniken, I. Z. Liu, S. Kang, Y. Trojer, P. Garcia, B. A. A quantitative atlas of histone modification signatures from human cancer cells. Epigenetics Chromatin, 6:20, . (PMID: 23826629, PMCID: PMC3710262)

Hitosugi, T. Zhou, L. Fan, J. Elf, S. Zhang, L. Xie, J. Wang, Y. Gu, T. L. Aleckovic, M. LeRoy, G. Kang, Y. Kang, H. B. Seo, J. H. Shan, C. Jin, P. Gong, W. Lonial, S. Arellano, M. L. Khoury, H. J. Chen, G. Z. Shin, D. M. Khuri, F. R. Boggon, T. J. Kang, S. He, C. Chen, J. Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation. Nat Commun, 4:1790, . (PMID: 23653202, PMCID: PMC3648882)

Hitosugi, T. Zhou, L. Elf, S. Fan, J. Kang, H. B. Seo, J. H. Shan, C. Dai, Q. Zhang, L. Xie, J. Gu, T. L. Jin, P. Aleckovic, M. Leroy, G. Kang, Y. Sudderth, J. A. Deberardinis, R. J. Luan, C. H. Chen, G. Z. Muller, S. Shin, D. M. Owonikoko, T. K. Lonial, S. Arellano, M. L. Khoury, H. J. Khuri, F. R. Lee, B. H. Ye, K. Boggon, T. J. Kang, S. He, C. Chen, J. Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell, 22:585-600, . (PMID: 23153533, PMCID: PMC3500524)

Chakrabarti, R. Hwang, J. Andres Blanco, M. Wei, Y. Lukacisin, M. Romano, R. A. Smalley, K. Liu, S. Yang, Q. Ibrahim, T. Mercatali, L. Amadori, D. Haffty, B. G. Sinha, S. Kang, Y. Elf5 inhibits the epithelial-mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2. Nat Cell Biol, 14:1212-1222, . (PMID: 23086238, PMCID: PMC3500637)

Ell, B. Kang, Y. SnapShot: Bone Metastasis. Cell, 151:690-690.e1, . (PMID: 23101634)

Liang, Y. Wu, H. Lei, R. Chong, R. A. Wei, Y. Lu, X. Tagkopoulos, I. Kung, S. Y. Yang, Q. Hu, G. Kang, Y. Transcriptional network analysis identifies BACH1 as a master regulator of breast cancer bone metastasis. J Biol Chem, 287:33533-33544, . (PMID: 22875853, PMCID: PMC3460454)

Blanco, M. A. Leroy, G. Khan, Z. Aleckovic, M. Zee, B. M. Garcia, B. A. Kang, Y. Global secretome analysis identifies novel mediators of bone metastasis. Cell Res, 22:1339-1355, . (PMID: 22688892, PMCID: PMC3434351)

Chakrabarti, R. Wei, Y. Romano, R. A. DeCoste, C. Kang, Y. Sinha, S. Elf5 regulates mammary gland stem/progenitor cell fate by influencing notch signaling. Stem Cells, 30:1496-1508, . (PMID: 22523003)

Wendt, M. K. Schiemann, B. J. Parvani, J. G. Lee, Y. H. Kang, Y. Schiemann, W. P. TGF-beta stimulates Pyk2 expression as part of an epithelial-mesenchymal transition program required for metastatic outgrowth of breast cancer. Oncogene, In process, . (PMID: 22710711)

Peinado, H. Aleckovic, M. Lavotshkin, S. Matei, I. Costa-Silva, B. Moreno-Bueno, G. Hergueta-Redondo, M. Williams, C. Garcia-Santos, G. Ghajar, C. Nitadori-Hoshino, A. Hoffman, C. Badal, K. Garcia, B. A. Callahan, M. K. Yuan, J. Martins, V. R. Skog, J. Kaplan, R. N. Brady, M. S. Wolchok, J. D. Chapman, P. B. Kang, Y. Bromberg, J. Lyden, D. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med, 18:883-891, . (PMID: 22635005)

Koh, B. I. Kang, Y. The pro-metastatic role of bone marrow-derived cells: a focus on MSCs and regulatory T cells. EMBO Rep, 13:412-422, . (PMID: 22473297, PMCID: PMC3343352)

Celia-Terrassa, T. Meca-Cortes, O. Mateo, F. de Paz, A. M. Rubio, N. Arnal-Estape, A. Ell, B. J. Bermudo, R. Diaz, A. Guerra-Rebollo, M. Lozano, J. J. Estaras, C. Ulloa, C. Alvarez-Simon, D. Mila, J. Vilella, R. Paciucci, R. Martinez-Balbas, M. de Herreros, A. G. Gomis, R. R. Kang, Y. Blanco, J. Fernandez, P. L. Thomson, T. M. Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells. J Clin Invest, 122:1849-1868, . (PMID: 22505459, PMCID: PMC3366719)

Fang, W. Wei, Y. Kang, Y. Landweber, L. F. Detection of a common chimeric transcript between human chromosomes 7 and 16. Biol Direct, 7:49, . (PMID: 23273016, PMCID: PMC3538553)

Sethi, N. Kang, Y. Notch signaling: mediator and therapeutic target of bone metastasis. Bonekey Rep, 1:3, . (PMID: 23951415, PMCID: PMC3706003)

Lu, X. Mu, E. Wei, Y. Riethdorf, S. Yang, Q. Yuan, M. Yan, J. Hua, Y. Tiede, B. J. Lu, X. Haffty, B. G. Pantel, K. Massague, J. Kang, Y. VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging alpha4beta1-positive osteoclast progenitors. Cancer Cell, 20:701-714, . (PMID: 22137794, PMCID: PMC3241854)

Sethi, N. Kang, Y. Notch signalling in cancer progression and bone metastasis. Br J Cancer, 105:1805-1810, . (PMID: 22075946, PMCID: PMC3251892)

Ibrahim, T. Sacanna, E. Gaudio, M. Mercatali, L. Scarpi, E. Zoli, W. Serra, P. Ricci, R. Serra, L. Kang, Y. Amadori, D. Role of RANK, RANKL, OPG, and CXCR4 tissue markers in predicting bone metastases in breast cancer patients. Clin Breast Cancer, 11:369-375, . (PMID: 21764390)

Sethi, N. Kang, Y. Unravelling the complexity of metastasis - molecular understanding and targeted therapies. Nat Rev Cancer, 11:735-748, . (PMID: 21941285)

Korpal, M. Ell, B. J. Buffa, F. M. Ibrahim, T. Blanco, M. A. Celia-Terrassa, T. Mercatali, L. Khan, Z. Goodarzi, H. Hua, Y. Wei, Y. Hu, G. Garcia, B. A. Ragoussis, J. Amadori, D. Harris, A. L. Kang, Y. Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization. Nat Med, 17:1101-1108, . (PMID: 21822286, PMCID: PMC3169707)

Mercatali, L. Ibrahim, T. Sacanna, E. Flamini, E. Scarpi, E. Calistri, D. Ricci, M. Serra, P. Ricci, R. Zoli, W. Kang, Y. Amadori, D. Bone metastases detection by circulating biomarkers: OPG and RANK-L. Int J Oncol, 39:255-261, . (PMID: 21491082)

Blanco, M. A. Aleckovic, M. Hua, Y. Li, T. Wei, Y. Xu, Z. Cristea, I. M. Kang, Y. Identification of staphylococcal nuclease domain-containing 1 (SND1) as a Metadherin-interacting protein with metastasis-promoting functions. J Biol Chem, 286:19982-19992, . (PMID: 21478147, PMCID: PMC3103372)

Zhang, X. Tamasi, J. Lu, X. Zhu, J. Chen, H. Tian, X. Lee, T. C. Threadgill, D. W. Kream, B. E. Kang, Y. Partridge, N. C. Qin, L. Epidermal growth factor receptor plays an anabolic role in bone metabolism in vivo. J Bone Miner Res, 26:1022-1034, . (PMID: 21542005, PMCID: PMC3179301)

Sethi, N. Dai, X. Winter, C. G. Kang, Y. Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells. Cancer Cell, 19:192-205, . (PMID: 21295524, PMCID: PMC3040415)

Tiede, B. Kang, Y. From milk to malignancy: the role of mammary stem cells in development, pregnancy and breast cancer. Cell Res, 21:245-257, . (PMID: 21243011, PMCID: PMC3193434)

Matsushima, K. Isomoto, H. Yamaguchi, N. Inoue, N. Machida, H. Nakayama, T. Hayashi, T. Kunizaki, M. Hidaka, S. Nagayasu, T. Nakashima, M. Ujifuku, K. Mitsutake, N. Ohtsuru, A. Yamashita, S. Korpal, M. Kang, Y. Gregory, P. A. Goodall, G. J. Kohno, S. Nakao, K. MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells. J Transl Med, 9:30, . (PMID: 21426561, PMCID: PMC3076245)

Blanco, M. A. Kang, Y. Signaling pathways in breast cancer metastasis - novel insights from functional genomics. Breast Cancer Res, 13:206, . (PMID: 21457525, PMCID: PMC3219178)

Lu, X. Kang, Y. Cell fusion hypothesis of the cancer stem cell. Adv Exp Med Biol, 714:129-140, . (PMID: 21506011)