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Zhiyuan Shen, MD, PhD

Selected Publications

  1. Huang, Y.Y., Dai, L., Gaines, D., Droz-Rosario, R., Lu, H., Liu, J. and Shen, Z. (2013) BCCIP Suppresses Tumor Initiation but Is Required for Tumor Progression. Cancer research, 73, 7122-7133.
  2. Yue, J., Lu, H., Lan, S., Liu, J., Stein, M.N., Haffty, B.G. and Shen, Z. (2013) Identification of the DNA repair defects in a case of dubowitz syndrome. PloS one, 8, e54389.
  3. Shen, Z. and Huhn, S. (2013) PTEN sumo-wrestles human RAD52 to mystery land. Cell cycle (Georgetown, Tex.), 12, 3585.
  4. Yue, J., Huhn, S. and Shen, Z. (2013) Complex roles of filamin-A mediated cytoskeleton network in cancer progression. Cell & bioscience, 3, 7.
  5. Jiang, X., Yue, J., Lu, H., Campbell, N., Yang, Q., Lan, S., Haffty, B.G., Yuan, C. and Shen, Z. (2013) Inhibition of filamin-a reduces cancer metastatic potential. International journal of biological sciences, 9, 67-77.
  6. Shen, Z., Huhn, S.C. and Haffty, B.G. (2013) Escaping death to quiescence: Avoiding mitotic catastrophe after DNA damage. Cell cycle (Georgetown, Tex.), 12.
  7. Shen, Z. (2013) Cancer biomarkers and targeted therapies. Cell & bioscience, 3, 6.
  8. Huang Y-Y, Lu H, Liu S, Droz-Rosario R, Shen Z. (2012) Requirement of Mouse BCCIP for Neural Development and Progenitor Proliferation. PLoS ONE 7(1): e30638. doi:10.1371/journal.pone.0030638, pages 1-12.
  9. Yue J, Lu H, Liu J, Berwick M, and Shen Z. (2012) Filamin-A as a marker and target for DNA damage based cancer therapy. DNA Repair (Amst). 11(2):192-200 (Epub 2011 Nov 2).
  10. Yue J, Lan S, Yuan C, and Shen Z.  (2012) Prognostic Values of Filamin-A Status for Topoisomerase II Poison Chemotherapy. International Journal of Biological Sciences. 8(4):442-50. (Epub 2012 Feb 29).
  11. Lu H, Huang Y, Droz-Rosario R, Liu J, Bhaumik M, White E, and Shen Z. (2011) Essential Roles of BCCIP in Mouse Embryonic Development and Structural Stability of Chromosomes. PLoS Genet 7 (9): e1002291. doi:10.1371/journal.pgen.1002291, Pages: 1-18.
  12. Shen Z (2011) Genomic instability and cancer: an introduction (Editorial). J Mol Cell Biol 3: 1-3.
  13. Zhu H, Yue J, Pan Z, Wu H, Cheng Y, Lu H, Ren X, Yao M, Shen Z, and Yang JM (2010) Involvement of Caveolin-1 in Repair of DNA Damage through Both Homologous Recombination and Non-Homologous End Joining. PLoS ONE 5(8): e12055. doi:10.1371/journal.pone.0012055.
  14. Yue J, Wang Q, Lu H, Brenneman M, Fan F, and Shen Z. (2009) The Cytoskeleton Protein Filamin-A Is Required for an Efficient Recombinational DNA Double Strand Break Repair. Cancer Research. 69:7978-7985 (Epub 2009 Oct 6).
  15. Liu J, Lu H, Ohgaki H, Merlo A, and Shen Z. (2009) Alterations of BCCIP, a BRCA2 interacting protein, in astrocytomas. BMC Cancer. 9:268 (8 pages).
  16. Fan J, Wray J, Meng X, and Shen Z. (2009) BCCIP is required for the nuclear localization of the p21 protein. Cell Cycle. 15;8(18):3019-24.
  17. Sayar H, Shen Z, Lee SJ, Royce M, Rabinowitz I, Lee F, Smith H, Eberhardt S, Maestas A, Lu H, Verschraegen C. (2009) Phase I study of capecitabine in combination with cisplatin and irinotecan in patients with advanced solid malignancies. Invest New Drugs. 27(2):153-8. (Epub 2008 Sep 5).
  18. Rewari A, Lu H, Parikh R, Yang Q, Shen Z, and Haffty BG (2009) BCCIP as a prognostic marker for radiotherapy of laryngeal cancer. Radiotherapy and Oncology, 90(2):183-8. (Epub 2008 Nov 27).
  19. Du Y, Zhou J, Fan J, Shen Z, Chen X. (2009) Streamline proteomic approach for characterizing protein-protein interaction network in a RAD52 protein complex. J Proteome Res. 8(5):2211-7.
  20. Wray J, Liu J, Nickoloff JA, and Shen Z. (2008) Distinct RAD51 Associations with RAD52 and BCCIP in Response to DNA Damage and Replication Stress. Cancer Research, 68(8): 2699-2707.
  21. Meng X, Yue J, Liu Z, and Shen Z. (2007) Abrogation of the Transactivation Activity of p53 by BCCIP Down-regulation, J. Biol. Chem. (E-publication on 2006-Nov-29-2006); 282(3): 1570-1576.
  22. Meng X, Fan J, and Shen Z. (2007) Roles of BCCIP in Chromosome Stability and Cytokinesis. Oncogene  (E-publication on Apr-23-2007); 26(43): 6253-6260.
  23. Lu H, Yue J, Meng X, Nickoloff JA, and Shen Z. (2007) BCCIP Regulates Homologous Recombination by Distinct Domains, and Suppresses Spontaneous DNA Damage. Nucleic Acid Research, 35: 7160-7170.
  24. Shen Z, and Nickoloff JA. (2007) Mammalian Homologous Recombination Repair and Cancer Intervention. In DNA Repair, Genetic Instability, and Cancer, Chapter 5, pp119-156. Editors: Wei Q, Li L, and Chen DJ. World Scientific Publishing Co. Pte. Ltd., Singapore.