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Hatem E. Sabaawy, MD, PhD

Selected Publications

  1. Sabaawy HE, Ikehara S, Adachi Y, Quan S, Feldman E, Kancherla R, Abraham NG, and T Ahmed. Enhancement of 5-fluorouracil cytotoxity on human colon cancer cells by retrovirus-mediated interferon-α gene*. International journal of Oncology 1999; 14: 1143-51.*The Winner of Current Awareness in Biomedicine: Gene Therapy publication, 1999.
  2. Sabaawy HE, Zhang F, Nasjletti A, Schwartzman M, and NG Abraham. Human Heme Oxygenase-1 Gene Transfer Lowers Blood Pressure and Promotes Growth in Spontaneously Hypertensive Rats. Hypertension 2001; 38(2): 210-5.
  3. Pine S, Yin C, Matloob Y, Sabaawy H, Sandoval C, Levendoglu-Tugal O, Ozkaynak M, and S. Jaybose. Quantitative real-time PCR detection of Occult CNS-Leukemia in children with acute lymphoblastic leukemia. Journal of Molecular Diagnostics 2005; 7: 127-32. PMID: 15681484. PMCID: PMC1867497.
  4. Sabaawy HE, Azuma M, Embree L, Tsai HJ, Starost MF, and DD Hickstein. TEL-AML1 transgenic zebrafish model of precursor B-cell acute lymphoblastic leukemia. Proceedings of the National Academy of Science, USA 2006; 103:15166-15171. PMID: 17015828. PMCID: PMC1622794.
  5. Sabaawy HE, Yin C, Sandoval C, Levendoglu-Tugal O, Wormser G, Jaybose S, and S. Pine. Lymphoproliferative clonal origin of AIDS-related Non-Hodgkin's lymphoma. Leukemia and Lymphoma 2007; 48: 812-815. PMID: 17454643.
  6. Patel N, Klassert TE, Greco SJ, Patel SA, Reddy BY, Bryan M, Campbell N, Kokorina NA, Sabaawy HE*, and Rameshwar P. Developmental activation pathways in TAC1 expression in human mesenchymal stem cells-derived peptidergic neurons for the repair of spinal cord injury in zebrafish. Stem Cells and Development, 2012; 21(2):308-320. PMID: 21671725; PMCID: PMC3258436. * Corresponding author. [Cover illustration].
  7. Kokorina NA, Granier C, Zakharkin SO, Marshall S, Rabson A, and Sabaawy HE. PDCD2 knockdown inhibits erythroid but not megakaryocytic lineage differentiation of human hematopoietic stem/progenitor cells. Experimental Hematology 2012; 40(12):1028-1042. PMID: 22922207.
  8. Kramer J, Granier C, Marshall S, Piso K, Hand J, Rabson A, and Sabaawy HE. PDCD2 controls hematopoietic stem cell differentiation during development. Stem Cells and Development, 2013; 22(1):58-72. PMID: 22800338.
  9. El Ansary M, Mogawer S, Elhamid SA, Alwakil S, Aboelkasem F, Sabaawy HE, Abdelhalim O. Immunotherapy by autologous dendritic cell vaccine in patients with advanced HCC. Journal of Cancer Research Clinical Oncology 2013; 139(1):39-48. PMID: 22886490.
  10. Balow SA, Pierce L, Zentner GE, Davis S, Sabaawy HE, McDermott BM, and PC Scacheri. Knockdown of fbxl10/kdm2bb rescues chd7 morphant phenotype in a zebrafish model of CHARGE syndrome. Developmental Biology 2013; 382(1):57-69. PMID: 23920116. PMCID: PMC3816111.
  11. Sabaawy, HE. Genetic heterogeneity and clonal evolution of tumor cells and their impact on precision cancer medicine. Journal of Leukemia 2013; 1(4):1000124. PMID: 24558642. PMCID: PMC3927925.
  12. Bansal N, Davis S, Tereshchenko I, Budak-Alpdogan T, Zhong H, Stein MN, Kim IY, DiPaola RS, Bertino JR, and Sabaawy, HE. Enrichment of human prostate cancer cells with tumor initiating properties in mice and zebrafish xenografts by differential adhesion. Prostate 2014; 74:187-200. PMID: 24154958. PMCID:  PMC3939797.
  13. Granier CJ, Wang W, Tsang T, Steward R, Sabaawy HE, Bhaumik M, and Rabson AB. Conditional inactivation of PDCD2 inhibits cell cycle progression and induces p53 activation during mouse embryonic development. Biology Open. 2014; 3(9):821-31. PMID: 25150276. PMCID: PMC4163659.
  14. Elkheir WA, Gabr H, Awad R, Ghannam O, Barakat Y, Farghali H, El Maadawi Z, Ewes I, and Sabaawy HE. Autologous adherent BM-derived cell therapy combined with physical therapy induces partial recovery in chronic spinal cord injury patients. Cell Transplantation 2014; 23(6):729-45. PMID: 23452836.
  15. Gabr H, Elkheir WA, Farghali H, El Maadawi Z, Ismail Z, Zickri M, El Maadawi Z, Kishk N, and Sabaawy HE. Intrathecal transplantation of autologous adherent bone marrow cells induces functional neurological recovery in a canine model of spinal cord injury. Cell Transplantation 2014 Jul 15 Epub. PMID: 25199146.
  16. Bansal N, Bartucci M, Yussuf S, Davis S, Huselid E, Cao L, Sydorenko N, Moon YC, Sindhu TS, Zhong H, Stein MN, Kim IY, Medina DJ, Davis TW, DiPaola RS, Bertino JR, and Sabaawy, HE. Development of inhibitors targeting Bmi-1 in human prostate tumor-initiating cells. Nature Communications (Under revision).
  17. Sabaawy HE, Tiko M. Cartilage regeneration for treatment of osteoarthritis: A paradigm for non-­surgical intervention. Therapeutic Advances in Musculoskeletal Disease (Under review).
  18. Samir A, Elgamal BM, Gabr H, and Sabaawy HE. Nanotechnology applications in hematological malignancies. Oncology Reports (Under review).
  19. Mehta M, Khan A, Danish S, Hafty B and Sabaawy HE. Radiosentization of glioblastoma stem-like cells by modulating BMI-1 and AKT signaling. Clinical Cancer Research (Under review).