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Amale Laouar, PhD

Selected Publications

  1. Laouar  A  and  Bauvois  B. “Characterization  and  modulation  of  cell  surface  proteases  on  human myeloblastic (HL-60) cells and comparison to myeloid blood cells”. Immunol. Lett. 34: 257-266, 1992
  2. Laouar  A,  Villiers  C,  Sanceau  J,  Maison  C,  Colomb  M,  Wietzerbin  J,  Bauvois  B.  “Inactivation of interleukin-6 by human monoblastic U937 cells involves both cell surface and peptidyl transferase activities”. Eur. J. Biochem. 215: 825-831, 1993
  3. Bauvois B and  Laouar A. “Distinct cellular functions mediated by hematopoietic cell-surface proteases”. Advances in Neuroimmunology. 3: 171-181, 1993
  4. Laouar A, Wietzerbin J, Bauvois B. “Divergent regulation of cell surface protease expression in HL-60 cells differentiated into macrophages with GM-CSF or neutrophils with retinoic acid”. International Immunol. 5: 965-973, 1993
  5. Crespeau H, Laouar A, Rochu D. "Polyclonal DNase abzyme formed by the anti-idiotypique interne image method". Compte Rendus de l’Academie des Sciences.  317: 819-23, 1994
  6. Laouar A, Wietzerbin J, Bauvois B. “Protease-catalyzed conversion of insulin like growth factor-1 and interleukin -6 into high molecular mass species through the sequential action of hematopoietic surface associated cathepsin G and gamma-glutamyl transpeptidase-related activities”. Eur. J. Biochem.  223: 617-24, 1994
  7. Bauvois B,  Laouar A, Rouillard D, Wietzerbin J. “Inhibition of gamma-glutamyl transferase activity at the surface of human myeloid cells is correlated with macrophage maturation and transforming growth factor - beta production. Cell Growth and Differentiation. 6: 1163-1170,1995
  8. Xie B,  Laouar A, Huberman E. “Fibronectin -mediated cell adhesion is required for induction of 92-kDa type  IV  collagenase/gelatinase  (MMP-9)  gene expression  during  macrophage  differentiation”.    J.  Biol. Chem. 273: 11576-11582, 1998
  9. Xie  B,  Laouar  A,  Huberman  E.  “Autocrine  regulation  of  macrophage  differentiation  and  92-kDa Gelatinase production by tumor necrosis factor alpha via alpha5 beta1 integrin in HL-60 cells.   J. Biol. Chem. 273: 11583-11588, 1998
  10. Semizarov D, Glesne D,  Laouar A, Schiebel K, Huberman E. “A novel lineage-specific protein kinase crucial for myeloid maturation”. Proc.Natl.Acad.Sci USA.  95: 15412-7, 1998
  11. Lopez  S,  Peiretti  F,  Morange  P,  Laouar  A,  Fossat  C,  Bonardo  B,  Huberman  E,  Juhan-Vague  I, NalboneG.   “Activation   of   plasminogen   activator   inhibitor-1   synthesis   by   phorbolesters   in   human promyelocyte HL-60--roles of PCKbeta and MAPK p42”. Thromb Haemost. 81:415-22, 1999
  12. Laouar A, Collart F.R,          Chubb C, Xie B, Huberman E. “Interaction between integrin and secreted fibronectin is involved in macrophage differentiation of human HL-60 myeloid leukemia cells ” J. Immunol. 162: 407-14, 1999
  13. Laouar A, Glesne D, Huberman E. “Involvement of protein kinase C-beta and ceramide in tumor necrosis factor -alpha-induced but not Fas-induced apoptosis of human myeloid leukemia cells”.  J. Biol. Chem.  274:23526-23534, 1999
  14. Laouar A, Glesne D, Huberman E. “Protein kinase C-beta (1), fibronectin, alpha (5) beta (1) integrin, and tumor necrosis factor alpha are required for phorbol diester-induced apoptosis in human myeloid leukemia cells”. Mol Carcinog.  32: 195-205, 2001
  15. Gu X, Laouar A, Wan J, Daheshia M, Lieberman J, Yokoyama WM, Katz HR, Manjunath N. " The gp49B1 inhibitory receptor regulates the INF-gamma responses to T cells and NK cells". J. Immunol. 170:4095-101, 2003
  16. Laouar A, Vargas D, Haridas V, Zhinana X, Chaplin D, van Lier RA, Swamy, MN. “A novel CD70+ antigen presenting cell controls the expansion and differentiation of T cells in the intestinal mucosa.”  Nature Immunology. 6:698-706, 2005. Accompanied by News & Views, Nature Immunology. Johansson C & Kelsall BL. Affecting the effectors. A kick in the gut? 6:644-646, 2005
  17. Freyschmidt EJ, Mathias CB, MacArthur DH,  Laouar A, Narasimhaswamy M, Weih F, Oettgen HC. Skin inflammation in RelB (-/-) mice leads to defective immunity and impaired clearance of vaccinia virus. J. Allergy Clin Immunol. 119: 671-9, 2007
  18. Laouar A*, Manocha M, Wan M, Yagita H, van Lier RA, Manjunath N. (*Corresponding  author) “Distinct  NK  receptors  are  imprinted  on  CD8  T  cells  in  the  mucosa  and periphery during the same antigen challenge: Role of tissue-specific factors. Cutting Edge-J. Immunol. 178: 652-656, 2007
  19. Scott JE, ElKhal A, Freyschmidt EJ, MacArthur DH, McDonald D, Howell MD, Leung DY, Laouar A, Manjunath N, Bianchi T, Boes M, Oettgen HC, Geha RS. Impaired immune response to vaccinia virus inoculated at the site of cutaneous allergic inflammation. J Allergy Clin Immunol. 120:1382-8, 2007
  20. Kumar P, Ban HS, Kim SS, Wu H, Pearson T, Greiner DL,  Laouar A, Yao J, haridas V, Habiro K,    Yang YG, Jeong JH, Lee KY, Kim YH, Kim SW, Peipp M, Fey GH, Manjunath N, Shultz LD, Lee SK, Shankar P. “T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice”. Cell.  134: 577-86, 2008
  21. Laouar A*, Manocha M, Haridas, V, Manjunath N* (*Corresponding author) “Concurrent generation of effector and memory CD8 T cells during vaccinia virus infection”. PLoS ONE 3(12): e4089, 2008
  22. Manocha M, Svend R,  Laouar A, Liao G, Bhan A, Borst J, Terhorst C, Manjunath N. Blocking of CD27 costimulatory pathway suppresses experimental colitis. J. Immunol. 183: 270-6, 2009
  23. Freyschmidt EJ, Mathias CB, MacArthur DH, Laouar A, Narasimhaswamy M, Hofer M, Werbel, MA, Campbel J, chatial T and Oettgen HC. “Skin inflammation arising from cutaneous Treg deficiency leads to impaired viral immune responses”. J Immunol. 185:1295-302, 2010
  24. Sinsimer D, Esseghir A, Tang M, and  Laouar A*. (*Corresponding author) “The common prophylactic therapy for bowel surgery is ineffective for clearing Bacteroidetes, the primary inducers of systemic inflammation, and causes faster death in response to intestinal barrier damage in mice”. BMJ Open Gastroenterology
  25. Zhang A,  Laouar A, Denzin L, and Sant’Angelo D. “Heritable inactivation of Zbtb16 (PLZF) is induced during thymocyte development and is maintained in mature T cells”. In review
  26. Cabinian A, Sinsimer D, Esseghir A, Tang M, and  Laouar A* (*Corresponding author) “SLAMF4 is a major marker of intestinal immune cells that is induced by the gut microflora and positively regulates immunity against enteric infection”. In review
  27. Sinsimer D, Cabinian A, Toma A, Essaghir A, Tang M, and  Laouar A*. (*Corresponding author) “Immunity transfer from mother to infant: Cytotoxic CD8 T cells from the mother’s breast milk survive the neonatal gastrointestinal tract and home exclusively to the Peyer’s patches (PP) of the pup’s intestines”. In review
  28. Tae June,  Amale Laouar*, Yasmina Laouar* (*Corresponding author) Regulatory mechanisms of innate lymphoid ILC1 and ILC3 in the gut mucosa” In review