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S. David Kimball, PhD

Selected Publications

  1. J.T. Bagdanoff, M.S. Donoviel, A. Nouraldeen, M. Carlsen, T.C. Jessop, J. Tarver, S. Aleem, L. Dong, H. Zhang, L. Boteju, J. Hazelwood, J. Yan, M. Bednarz, S. Layek, I.B. Owusu, S. Gopinathan, L. Moran, Z. Lai, J. Kramer, S.D. Kimball, P. Yalamanchili, W.E. Heydorn, K.S. Frazier, B. Brooks, P. Brown, A. Wilson, W.K. Sonnenburg, A. Main, K.G. Carson, T. Oravecz, D. J. Augeri.  Inhibition of Sphingosine 1-Phosphate Lyase for the Treatment of Rheumatoid Arthritis: Discovery of (E)-1-(4-(1R,2S,3R)-1,2,3,4-Tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone Oxime (LX2931) and (1R,2S,3R)-1-(2-(Isoxazoly-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol (LX2932).  J. Med. Chem. 2010 (53) 8650-8662.
  2. R. Bakthavatchalam and S. D. Kimball.  Modulators of TRP Ion Channels.  Annual Reports in Medicinal Chemistry 2010 (45) 37-50.

3.    J.E. Tarver, T.C. Jessop, M. Carlsen, D.J. Augeri, Q. Fu, J.P. Healy, A. Heim-Riether, A. Xu,  J.A. Taylor, M. Shen, P.E. Keyes, S.D. Kimball, X-C. Yu, M. Miranda, Q. Liu, J.C. Swaffield, A. Nouraldeen, A.G.E. Wilson, R. Finch, K. Jhaver, A. M. DiGeroge Foushee, S. Anderson, T. Oravecz, K.G. Carson.  5-Fluorocytosine Derivatives as Inhibitors of Deoxycytidine Kinase.  Bioorg. Med. Chem. Lett. 2009 (19) 6780-6783.

4.    N.C. Goodwin, R. Mabon, B.A. Harrison, M.K. Shadoan, Z.Y. Almstead, Y. Xie, J. Healy, L.M. Buhring, C.M. DaCosta, J. Bardenhagen, F. Mseeh, Q. Liu, A. Nouraldeen, A.G.E. Wilson, S.D. Kimball, D.R. Powell, D.B. Rawlins.  Novel L-Xylose Derivatives as Selective Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitors for the Treatment of Type 2 Diabetes.  J. Med. Chem. 2009 (52) 6201-6204.

5.    B.A. Harrison, N.A. Whitlock, M.V. Voronkov, Z.Y. Almstead, K.J. Gu, R. Mabon, M. Gardyan, B.D. Hamman, J. Allen, S. Gopinathan, B. McKnight, M. Crist, Y. Zhang, Y. Liu, J. Zhou, N. Paten, Q. Liu, A.G.E. Wilson, S.D. Kimball, D.S. Rice, D.B. Rawlins.  A Novel Class of LIM-kinase 2 Inhibitors for the Treatment of Ocular Hypertension and Associated Glaucoma.  J. Med. Chem 2009 (52) 6515-6518.

6.    Z.-C. Shi, A. Devasagayaraj, K. Gu, H Jin, B. Marinelli, L. Samala, S. Scott, T. Stouch, A. Tunoori, Y. Wang, Y. Zang, C. Zhang, S.D. Kimball, A.J. Main, W. Sun, Q. Yang, A. Nouraldeen,  X.-Q. Yu,  E. Buxton, S. Patel, N. Nguyen, J. Swaffield, D.R. Powell, A. Wilson, Q. Liu.  Modulation of Peripheral Serotonin Levels by Novel Tryptophan Hydroxylase Inhibitors for the Potential Treatment of Functional Gastrointestinal Disorders.  J. Med. Chem. 2008 (51) 3684-3687.

7.    B.E. Fink, A.V. Gavai, J.S. Tokarski, B. Goyal, R. Misra, H-Y. Xiao, S.D. Kimball, W-C. Han, D. Norris, T.E. Spires, D. You, M.M. Gottardis, M.V. Lorenzi, G.D. Vite.  Identification of a Novel Series of Tetrahydrodibenzazocines as Inhibitors of 17?-hydroxysteroid dehydrogenase type 3.  Bioorg. Med. Chem. Lett. 2006 (16) 1532-1536.

8.    R.N. Misra, H.Y. Xiao, K.S. Kim, S. Lu, W.C. Han, S.A. Barbosa, J.T. Hunt, D.B. Rawlins, W. Shan, S.Z. Ahmed, L. Qian, B.C. Chen, R. Zhao, M.S. Bednarz, K.A. Kellar, J.G. Mulheron, R. Batorsky, U. Roongta, A. Kamath, P. Marathe, S. A. Ranadive, J. S. Sack, J.S. Tokarski, N.P. Pavletich, F.Y.F. Lee, K.R. Webster, S.D. Kimball.  N-(Cycloalkylamino)acyl-2-aminothiazole Inhibitors of Cyclin-Dependent Kinase 2.  N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide (BMS-387032), a Highly Efficacious and Selective Antitumor Agent.  J. Med. Chem. 2004 (47) 1719-1728.

9.    R. N. Misra, H. Y. Xiao, D. K. Williams, K. S. Kim, S. Lu,  K. A. Kellar, J. G. Mulheron, R. Batorsky, S. D. Kimball, F. Y. Lee, K. R. Webster.  Synthesis and Biological Activity of N-Aryl-2-Aminothiazoles.  Pan Inhibitors of Cyclin-Dependent Kinases.  Bioorg. Med. Chem. Lett. 2004 (14) 2973-77.

10. R. N. Misra, H. Y. Xiao, D. B. Rawlins, W. Shan, K. A. Kellar, J. G. Mulheron, J. S. Sack, J. S. Tokarski, S. D. Kimball, K. R. Webster.  1H-Pyrazolo[3,4-b]pyridine Inhibitors of Cyclin-dependent Kinases.  Highly Potent 2,6-Difluorophenacyl Analogues.  Bioorg. Med. Chem. Lett. 2003 (13) 2405-2408.

11. R. N. Misra, D. B. Rawlins, H. Y. Xiao, W. Shan, I.  Bursuker, K. A. Kellar, J. G. Mulheron, J. S. Sack, J. S. Tokarski, S. D. Kimball, K. R. Webster.  1H-Pyrazolo[3,4-b]pyridine Inhibitors of Cyclin-Dependent Kinases.  Bioorg. Med. Chem. Lett. 2003 (13) 1133-1136.

12. K.S. Kim, S.D. Kimball, R.N. Misra, D.B. Rawlins, J.T. Hunt, H.Y. Xiao, S. Lu, L. Qian, W.C. Han, W. Shan, T. Mitt, Z.W. Cai, M.A. Poss, H. Zhu, J.S. Sack, J.S. Tokarski, C.Y. Chang, N. Pavletich, A. Kamath, W.G. Humphreys, P. Marathe, I. Bursuker, K.A. Kellar, U. Roongta, R. Batorsky, J.G. Mulheron, D. Bol, C.R. Fairchild, F.Y. Lee, K.R. Webster.  Discovery of Aminothiazole Inhibitors of Cyclin Dependent Kinase 2: Synthesis, X-ray Crystallographic Analysis and Biological Activities.  J Med Chem. 2002 (45) 3905-3927.

  1. S.D. Kimball and K.R. Webster.  Cell Cycle Kinases and Checkpoints.  Annual Reports in Medicinal Chemistry 2001 (36) 139-148.
  2. K.S. Kim, J.S. Sack J.S. Tokarski, L. Qian, S.T. Chao, L Leith, Y.F. Kelly, R.N. Misra, J.T. Hunt, S.D. Kimball, W.G. Humphreys, B.S. Wautlet, J.G. Mulheron, K.R. Webster.  Thio- and Oxoflavopiridols, Cyclin-Dependent Kinase 1-Selective Inhibitors: Synthesis and biological Effects.  J Med Chem. 2000 (43) 4126-4134.
  3. K.R. Webster and S.D. Kimball.  “Novel Drugs Targeting the Cell Cycle”.  Emerging Drugs 2000 (5) 45-59.