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Fang Liu, PhD

Selected Publications

Liu, F. (2008) Regulation of Smad activity by phosphorylation in TGF-ß in cancer therapy, pp 105-123, edited by S. Jakowlew, Humana Press, Totowa, USA

Uttamsingh, S., Bao, X., Nguyen, K. T., Bhanot, M., Chan, J. L.-K., Liu, F., Chu, T. T., and Wang, L.-H. (2008) Synergistic effect between EGF and TGF-ß1 in inducing oncogenic properties of intestinal epithelial cells. Oncogene 27, 2626-2634.

Liu, F. (2008) PCTA: A new player in TGF-ß signaling. Sci. Signal. 1, pe49.

Baughn, L. B., Di Liberto, M., Niesvizky, R., Cho, H. J., Jayabalan, D., Lane, J. Liu, F., and Chen-Kiang, S. (2009) Cdk2 phosphorylation of Smad2 disrupts TGF-ß transcriptional regulation in resistant primary bone marrow myeloma cells. J. Immunol. 182, 1810-1817.

Wang, G., Matsuura, I., He, D., and Liu, F. (2009) Transforming growth factor-ß-inducible phosphorylation of Smad3. J. Biol. Chem. 284, 9663-9673.

Fan, G., Fan, Y., Gupta, N., Matsuura, I., Liu, F., Zhou, X., Lu, K.-P. and Gélinas, C. (2009) Peptidyl-prolyl isomerase Pin1 markedly enhances the oncogenic activity of the Rel proteins in the NF-kB family. Cancer Res. 69, 4589-4597.

Matsuura, I., Chiang, K.-N., Lai, C.-Y., He, D., Wang, G., Ramkumar, R.,Uchida, T., Ryo, A., Lu, K. P., and Liu, F. (2010). Pin1 promotes TGF-ß-induced migration and invasion. J. Biol. Chem. 285, 1854-1864.

Sasseville, M., Ritter, L. J., Nguyen, T., Liu, F., Mottershead, D. G., Russell, D. L., and Gilchrist, R. B. (2010). Growth differentiation factor 9 signaling requires ERK1/2 activity in mouse granulosa and cumulus cells. J. Cell Sci. 123, 3166-3176.

Chang, X., Liu, F., Wang, X., Lin, A., Zhou, H., and Su, B. (2011) The kinases MEKK2 and MEKK3 regulate transforming growth factor-ß-mediated helper T cell differentiation. Immunity 34, 201-212.

Liu, F. (2011) Inhibition of Smad3 activity by cyclin D-CDK4 and cyclin E-CDK2 in breast cancer cells. Cell Cycle 10, 186.

So, J. Y., Lee, H. J., Smolarek, A. K., Paul, S., Maehr, H., Uskokovic, M., Zheng, X., Conney, A., Cai, L., Liu, F., and Suh, N. (2011) A novel Gemini vitamin D analog represses the expression of a stem cell marker CD44 in breast cancer. Mol. Pharmacol. 79, 360-367.

Cohen-Solal KA, Merrigan KT, Chan JL, Goydos JS, Chen W, Foran DJ, Liu F, Lasfar A, Reiss M. (2011) Constitutive Smad linker phosphorylation in melanoma: a mechanism of resistance to transforming growth factor-β-mediated growth inhibition. Pigment Cell Melanoma Res. 24, 512-524.

Dhar-Mascareno, M., Belishov, I., Liu, F., and Mascareno, E. J. (2012) Hexim-1 modulates androgen receptor and the TGFb signaling during the progression of prostate cancer. Prostate 72,1035-1044.

Mascareno, E., Galatioto, J., Rozenberg, I., Salciccioli, L., Kamran, H., Lazar, J. M., Liu, F., Pedrazzini, T., Siddiqui, M. A. (2012) Cardiac lineage protein-1 (CLP-1) regulates cardiac remodeling via transcriptional modulation of diverse hypertrophic and fibrotic responses and angiotensin II-transforming growth factor-beta (TGF-beta) signaling axis. J. Biol. Chem. 287, 13084-13093.

Patsoukis N, Brown J, Petkova V, Liu F, Li L, Boussiotis VA. (2012) Selective effects of PD-1 on Akt and Ras pathways regulate molecular components of the cell cycle and inhibit T cell proliferation. Sci Signal. 5, ra46.

Bae E, Kim SJ, Hong S, Liu F, Ooshima A. (2012) Smad3 linker phosphorylation attenuates Smad3 transcriptional activity and TGF-β1/Smad3-induced epithelial-mesenchymal transition in renal epithelial cells. Biochem Biophys Res Commun. E-pub ahead of print

Abushahba W, Olabisi OO, Jeong BS, Boregowda RK, Wen Y, Liu F, Goydos JS, Lasfar A, Cohen-Solal KA. (2012) Non-Canonical Smads Phosphorylation Induced by the Glutamate Release Inhibitor, Riluzole, through GSK3 Activation in Melanoma. PLoS One Epub ahead of print