Researcher Profiles

Return to member profile

Hua Zhong, MD, PhD, FCAP

Selected Publications

  1. Zhong H, Agani F, Baccala AA, Laughner E, Rioseco-Camacho N, Isaacs WB, Simons JW, Semenza GL. Increased expression of hypoxia inducible factor - 1alpha in rat and human prostate cancer. Cancer Res 1998; 58(23):5280-4.
  2. Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, Zagzag D, Buechler P, Isaacs WB, Semenza GL, Simons JW. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res 1999; 59(22): 5830-5.
  3. Zhong H, Chiles K, Feldser D, Laughner E, Hanrahan C, Georgescu MM, Simons JW, Semeza GL. Modulation of hypoxia-inducible factor 1alpha expression by the EGF/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 2000; 60:1541-5.
  4. Bos R, Zhong H, Hanrahan C, Mommers E, Semenza G, Pinedo H, Abeloff M, Simons J, van Diest P, van Der Wall E. Levels of hypoxia-inducible factor-1alpha during breast carcinogenesis. J Natl Cancer Inst 2001; 93(4):309-14.
  5. Mabjeesh N, Post D, Willard M, Kaur B, Van Meir E, Simons J, Zhong H. Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells. Cancer Res 2002; 62(9):2478-82.
  6. Govindarajan B, Bai X, Cohen C, Zhong H, Kilroy S, Moses M, Arbiser JL. Malignant transformation of melanocytes to melanoma by constitutive activation of mitogen-activated protein kinase kinase (MAPKK) signaling. J Biol Chem 2003; 278(11):9790-5.
  7. Mabjeesh N, Willard M, Zhong H, Simons J. Androgens stimulate hypoxia inducible factor 1 activation via autocrine loop of tyrosine kinase receptor/phosphatidylinositol 3’-kinase/protein kinase B in prostate cancer cells. Clin Cancer Res 2003; 9(7):2416-25.
  8. Mabjeesh NJ, Escuin D, LaVallee TM, Pribluda VS, Swartz GM, Johnson MS, Willard MT, Zhong H, Simons JW, Giannakakou P. 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer Cell 2003; 3(4):363-75.
  9. Zhong H, Willard M, Simons J. NS398 reduces hypoxia-inducible factor (HIF)-1alpha and HIF-1 Activity: multiple-level effects involving COX-2- dependent and independent mechanisms. Int J Cancer 2004; 112(4):585-95.
  10. Cai Z, Zhong H, Bosch-Marce M, Fox-Talbot K, Wang L, Wei C, Trush MA, Semenza GL. Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1alpha. Cardiovasc Res 2008; 77(3): 463-70.
  11. Wang RX, Jin FS, Zhong H. A Novel experimental hypoxia chamber for cell culture.  Am J Cancer Res 2014; 4(1):53-60.
  12. Bansal N, Davis S, Tereshchenko I, Budak-Alpdogan T, Zhong H, Stein MN, Kim IY, DiPaola RS, Bertino JR, Sabaawy HE. Enrichment of human prostate cancer cells with tumor initiating properties in mouse and zebrafish xenografts by differential adhesion. The Prostate 2014; 74(2):187-200.
  13. Zhong H, Wang R, Kelavkar U, Wang CY, Simons JW. 15-Lipoxygenas 1 promotes hypoxia-inducible factor 1a turnover and reduces vascular endothelial growth factor expression: Implications for angiogenesis. Cancer Med 2014; 3(3): 514–525.
  14. Pandya HJ, Kim HT, Roy R, Chen W, Cong L, Zhong H, Foran D, Desai JP; Fabrication of microchips for measuring bio-impedance of benign and cancerous breast tissues. Sensors & Actuators: B. Chemical 2014; 199:259-268.
  15. Cai-McRae X, Zhong H, Karantza V. Sequestosome 1/p62 facilitates HER2-induced Mammary tumorigenesis through multiple signaling pathways.  Oncogene 2014, Aug 4 [Epub ahead of print].