Researcher Profile

Lauren M. Aleksunes, PharmD, PhD, DABT

Assistant Professor of Pharmacology and Toxicology
Ernest Mario School of Pharmacy
Rutgers, The State University of New Jersey

EOHSI
170 Frelinghuysen Road, Room 426
Piscataway, NJ 08854

Phone: (848) 445-5518
Email: aleksunes@eohsi.rutgers.edu

Assistant: Sandi Selby
(848) 445-0213
Email: selby@eohsi.rutgers.edu

Links


Research Program Alignment

Membership Type: Full


Research Interests

  • Changes in function of drug transporters in the kidneys alter susceptibility of patients to adverse events such as cisplatin-induced renal injury. Overexpression of the efflux transporter multidrug resistance-associated protein 2 (MRP2) has been associated with resistance to cisplatin cytotoxicity in a number of cancer cell lines. MRP2 is also expressed in rodent and human kidneys. Our hypothesis is that MRP2 is responsible for the renal excretion of cisplatin and that loss of MRP2 function increases susceptibility of the kidney to toxicity.

The content for this Research Profile is maintained by Paul Novembre (novembre@cinj.rutgers.edu)