Researcher Profile

Shridar Ganesan, MD, PhD

Associate Director for Translational Science and Director of Functional Genomics Shared Resource at the Rutgers Cancer Institute of New Jersey
Associate Professor of Medicine and Pharmacology
Robert Wood Johnson Medical School
Rutgers, The State University of New Jersey

Rutgers Cancer Institute of New Jersey
195 Little Albany Street
New Brunswick, NJ 08901-1914

Phone: (732) 235-5211

Assistant: Jacqueline Harris
(732) 235-7428

Research Program Alignments

Membership Type: Full

Research Interests

  • DNA repair mechanisms and chromatin biology
  • Biology of BRCA1 and 53BP1 in DNA repair, tumorigenesis, and chemosensitivity
  • Genomic classification of human cancer

Selected Publications

Thatcher T, Ganesan S, Askar A, Rabitz H. A hybrid approach to modeling thedynamics of macromolecules. J Chem Phys 1986; 85:3655-3673.

Zawalich W, Zawalich K, Ganesan S, Calle R, Rasmussen H. Effects of thePhorbol elster 12-O-tetracecanoylphorbol-13-acetate on islet cell responsiveness. Biochem J 1990; 278:49-56.

Ganesan S, Calle R, Zawalich K, Smallwood J, Zawalich W, Rasmussen H. Glucose-induced translocation of protein kinase C in rat pancreatic islets. Proc Natl Acad Sci USA 1990; 87: 807-813.

Zawalich W, Zawalich K, Ganesan S, Calle R, Rasmussen H. Influence Of staurosporine on glucose-mediated and glucose-conditioned insulin secretion. Biochem J 1991; 279:807-813.

Ganesan S, Calle R, Zawalich K, Zawalcih W, Rasmussen H. Immunocytochemical localization of alpha-protein kinase C during glucose-induced insulin secretion in rat beta-cells. J Cell Biol 1992; 119:313-323.

Calle R, Ganesan S, Smallwood J, Zawalich W, Rasmussen H. MARCKS phosphorylation during glucose-induced insulin secretion from isolated pancreatic islets. J Biol Chem 1992; 267:18723-18727.

Scully R, Ganesan S, Brown M, De Caprio JA, Cannistra SA, Feunteun J, Schnitt S, Livingston DM. Location of BRCA1 in human breast and ovarian cancer cells. Science 1996; 272:123-125.

Scully R, Ganesan S, Vlasakova K, Chen J, Socolovsky M, Livingston DM. Genetic analysis of BRCA1 function in a defined tumor cell line. Mol Cell 1999; 4:1093-1099.

Wong KK, Chang S, Weiler SR, Ganesan S, Chaudhuri J, Zhu C, Artandi SE, Rudolph KL, Gottlieb GJ, Chin L, Alt FW, DePinho RA. Telomere Dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation. Nature Genet. 2000 26:85-88.

Garcia-Higuera I, Taniguchi T, Ganesan S, Meyn MS, Timmers C, Hejna J, Grompe M, D'Andrea AD. Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway. Mol Cell 2001 7:249-262.

Cantor SB, Bell DW, Ganesan S, Kass EM, Drapkin R, Grossman S, Wahrer DC, Sgroi DC, Lane WS, Haber DA, Livingston DM. BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function. Cell. 2001 105:149-160.

Ludwig T, Fisher P, Ganesan S, Efstratiadis A. Tumorigenesis in mice carrying a truncating Brca1 mutation. Genes Dev 2001; 15: 1188-1193.

Ganesan S, Silver DP, Greenberg RA, Avni D, Drapkin R, Miron A, Mok SC, Randrianarison V, Brodie S, Salstrom J, Rasmussen TP, Klimke A, Marrese C, Marahrens Y, Deng C-X, Feunteun J, Livingston DM. BRCA1 Supports XIST RNA Concentration on the Inactive X Chromosome. Cell 2002; 111: 393-405.

Avni, D., Yang, H., Martelli, F., Hofmann, F., ElShamy W., Ganesan S and Livingston, D. Active localization of the retinoblastoma protein in chromatin and its response to S phase DNA damage. Mol. Cell 2003 Vol 12: 735-746.

Kanellopoulou C, Muljo SA, Kung AL, Ganesan S, Drapkin R, Jenuwein T, Livingston DM, and Rajewsky K. Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes Dev. 2005; 19: 489-501.

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