Researcher Profile

Nanjoo Suh, PhD

Associate Professor of Chemical Biology
Ernest Mario School of Pharmacy
Rutgers, The State University of New Jersey

Susan L. Cullman Laboratory for Cancer Research
164 Frelinghuysen Road
Piscataway, NJ 08854-8020

Phone: (848) 445-8030
Email: nsuh@pharmacy.rutgers.edu

Assistant: Erica DiPaola
(732) 445-3400
Email: edipaola@pharmacy.rutgers.edu

Research Program Alignment

Membership Type: Full


Research Interests

  • Mechanistic study of cancer prevention with natural and synthetic agents such as triterpenoids, vitamin D and vitamin E family, stilbenoids and other chemopreventive agents in cancer cell lines as well as in animal models of breast cancer and colon cancer
  • Molecular mechanism studies targeting TGF-beta/Smad, nitric oxide synthase (iNOS), inducible cyclooxygenase (COX-2), and NF-kB in carcinogenesis and osteoarthritis

Selected Publications

Suh, N., Paul, S., Lee, H.J., Ji, Y., Lee, M.-J., Yang, C.S., Reddy, B.S., and Newmark, H.L., Mixed tocopherols inhibit N-methyl-N-nitrosourea induced mammary tumor growth in rats, Nutr. Cancer, 59: 76-81, 2007.

Lee, H.J., Ju, J., Paul, S., So, J.Y., DeCastro, A., Smolarek, A.K., Lee, M.-J., Yang, C.S., Newmark, H.L., and Suh, N., Mixed tocopherols prevent mammary tumorigenesis by inhibiting estrogen action and activating PPAR-g, Clin. Can. Res., 15: 4242-4249, 2009. [PMCID: PMC2753525]

Yang C.S., Suh, N., and Kong, A.-N.T., Does vitamin E prevent or promote cancer?, Can. Prev. Res., 5: 701-5, 2012.

Smolarek, A.K., So, J.Y., Thomas, P.E., Lee, H.J., Paul, S., Dombrowski, A., Wang, C.X., Saw, C. L-L., Khor, T.O., Kong, A.N.T., Reuhl, K., Lee, M.J., Yang, C.S., and Suh, N., Dietary tocopherols inhibit proliferation, regulate expression of nuclear receptors, increase Nrf2 and phase II enzymes, and decrease serum inflammatory markers during the development of mammary hyperplasia, Molecular Carcinogenesis, in press, 2012.

Smolarek, A.K., So, J.Y., Burgess, B., Kong. A.-N.T., Reuhl, K., Lin, Y., Shih, W., Lin, Y., Li, G., Lee, M.J., Chen, Y.-K., Yang, C.S., and Suh, N., Dietary administration of d- and g-tocopherol inhibits tumorigenesis in the animal model of estrogen-receptor positive, but not HER-2 breast cancer, Can. Prev. Res., in press, 2012.

Suh, N., Roberts, A.B., Birkey Reffey S., Miyazono, K., Itoh, S., ten Dijke, P., Heiss, E.H., Place, A.E., Risingsong, R., Williams, C.R., Honda, T., Gribble, G.W., Sporn, M.B., Synthetic triterpenoids enhance TGF-b/Smad signaling, Cancer Res., 63: 1371-1376, 2003.

Suh, N., Paul, S., Hao X., Simi, B., Xiao, H., Rimando, A.M., and Reddy, B.S., Pterostilbene, an active constituent of blueberries, suppresses aberrant crypt foci formation in the azoxymethane-induced colon carcinogenesis model in rats, Clin. Cancer Res., 13:350-355, 2007.

Lee, H.J., Ji, Y., Paul, S., Maehr, H., Uskokovic, M., and Suh, N., Activation of bone morphogenetic protein signaling by a Gemini vitamin D3 analog is mediated by Ras/protein kinase Ca, Cancer Res., 67: 11840-11847, 2007.

Lee, H.J., Paul, S., Atalla, N., Thomas, P.E., Lin, J., Yang, I., Buckley, B.T., Lu, G., Zheng, X., Lou, Y.-R., Conney, A. H., Maehr, H., Adorini, L.,  Uskokovic, M., and Suh, N., Gemini vitamin D analogs inhibit estrogen receptor positive and estrogen receptor negative mammary tumorigenesis without hypercalcemic toxicity, Cancer Prev. Res., 1: 476-484, 2008. [PMCID: PMC2753526]

Lee, H.J., So, J.Y., DeCastro, A., Smolarek, A., Paul, S., Maehr, H., Uskokovic, M., and Suh, N., Gemini vitamin D analog suppresses ErbB2-positive mammary tumor growth via inhibition of ErbB2/AKT/ERK signaling, J. Steroid Biochem. Mol. Biol., 121: 408-412, 2010. [PMCID: PMC2906695]

Paul, S., DeCastro, A., Lee, H.J., Smolarek, A.K., So, J.Y., Simi, B., Wang, C.X., Zhou, R., Rimando, A.M., and Suh, N., Dietary intake of pterostilbene, a constituent of blueberries, inhibits the b-catenin/p65 downstream signaling pathway and colon carcinogenesis in rats, Carcinogenesis, 31: 1272-1278, 2010. [PMCID: PMC2899944].

So, J.Y., Lee, H.J., Smolarek, A.K., Paul, S., Wang, C.X., Maehr, H., Uskokovic, M., Zheng, X., Conney, A.H., Cai, L., Liu, F., and Suh, N., A novel Gemini vitamin D represses the expression of a stem cell marker CD44 in breast cancer, Mol. Pharmacol., 79: 360-367, 2011. [PMCID: PMC3061370].

Suh, N., Reddy, B.S., DeCastro, A., Paul, S., Lee, H.J., Smolarek, A.K., So, J.Y., Simi, B., Wang, C.X., Janakiram, N.B., Steele, V. and Rao, C.V., Combination of atorvastatin with sulindac or naproxen profoundly inhibits colonic adenocarcinomas by suppressing the p65/b-catenin/cyclin D1 signaling pathway in rats, Cancer Prev. Res., 4: 1895-1902, 2011. [PMCID: PMC3208056]

Smolarek, A.K., and Suh, N., Chemopreventive activity of vitamin E in breast cancer: A focus on gamma-and delta-tocopherol, Nutrients, 3: 962-986, 2011. [PMCID: PMC3257724]

Suh, N., Paul, S., Lee, H.J., Yoon, T., Shah, N., Son, A.I., Reddi, A. H., Medici, D.D., Sporn, M.B., Synthetic triterpenoids, CDDO-Imidazolide and CDDO-Ethyl amide, induce chondrogenesis in calvarial organ cultures, Osteoarthritis Cartilage, 20: 446-450, 2012.

The content for this Research Profile is maintained by Paul Novembre (novembre@cinj.rutgers.edu)