Researcher Publications

Zhaohui Feng, MD, PhD

Selected Publications

  1. Xuetian Yue, Cen Zhang, Yuhan Zhao, Juan Liu, Alan W. Lin, Victor Tan, Justin M. Drake, Lianxin Liu, Michael N. Boateng, Jun Li, Zhaohui Feng (co-corresponding), and Wenwei Hu. Gain-of-function mutant p53 activates small GTPase Rac1 through SUMOylation to promote tumor progression. Genes & Development. 2017; In press.
  2. Zhang C, Liu J, Huang G, Zhao Y, Yue X, Wu H, Li J, Zhu J, Shen Z, Haffty BG, Hu W, Feng Z. Cullin3-KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression. Genes Dev. 2016 Sep 1;30(17):1956-70.
  3. Zhang C., Liu J., Zhao Y., Yue X., Zhu Y., Wang X., Blanco F., Wu h., Li S., Bhanot G, Haffty BG., Hu W., Feng Z. (2016) Glutaminase 2 is a novel negative regulator of Rac1 and mediates p53 function in suppressing cancer metastasis. eLIFE, 10.7554/eLife.10727. PMID: 26751560.
  4. Yue X., Zhao Y., Liu J., Zhang C., Yu H., Wang J., Zheng T., Liu L., Li J., Feng Z. (co-corresponding), Hu W. (2015) BAG2 promotes tumorigenesis through enhancing mutant p53 protein levels and function. eLIFE. 10.7554/eLife.08401. PMID: 26271008; PMCID: PMC4561369.
  5. Zhao Y, Zhang C, Yue X, Li X, Liu J, Yu H, Belyi VA, Yang Q, Feng Z (co-corresponding), Hu W. (2015) Pontin, a new mutant p53 binding protein, promotes gain of function of mutant p53. Cell Death & Differ, 2015;22(11):1824-36. PMID: 25857266.
  6. Yu H., Yue X., Zhao Y., Li X., Wu L., Zhang C., Liu Z., Lin K., Xu-Monette Z., Young K., Liu J., Shen Z., Feng Z.(co-corresponding), Hu W. (2014) LIF negatively regulates tumor suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers. Nature Communications, 5:5218. PMID: 25323535; PMCID: PMC4203416.
  7. Liu J, Zhang C, Wang X, ly P, Xu-Monette Z, Belyi V, Young KH, Hu W, Feng Z. E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis. Cell Death & Differ, 21(11):1792-804.
  8. Zhang C, Liu L, Liang YJ, Rui W, Lin M, Hong X, Liu L, Levine AJ, Hu W, Feng Z. Tumor-Associated Mutant p53 Drives the Warburg Effect. Nature Communications. 4:2935 doi: 10.1038/ncomms3935 (2013).
  9. Zheng T, Wang J, Zhao Y, Zhang C, Lin M, Wang X, Yu H, Liu L, Feng Z (co-corresponding), Hu W. Spliced MDM2 isoforms promote mutant p53 accumulation and gain-of-function in tumorigenesis. Nature Communications. 4:2996 doi: 10.1038/ncomms3996. (2013).
  10. Feng Z, Liu L, Zhang C, Zheng T, Wang J, Lin M, Wang X, Levine AJ, Hu W. Chronic restraint stress attenuates p53 function and promotes tumorigenesis. Proc Natl Acad Sci U S A. 109(18):7013-8 (2012).
  11. Zhang C. Wu R. Lin M. Wang X. Levine AJ., Hu W. Feng Z. Parkin, a novel p53 target gene, mediates the function of p53 in regulating glucose metabolism and the Warburg effect. Proc Natl Acad Sci USA., 108(39):16259-64. (2011).
  12. Hu W, Chang S. Chan, Rui Wu, Zhang Z, Sun Y, Song J, Levine AJ, Feng Z. Negative Regulation of Tumor Suppressor p53 by microRNA miR-504. Mol. Cell, 38, 689–699. (2010).
  13. Hu W. Zhang C., Wu R., Sun Y. Levine A.J. Feng Z. GLS2, a novel p53 target gene, regulates energy metabolism and antioxidant function. Proc Natl Acad Sci USA., 107(16):7455-60. (2010).
  14. Hu W., Feng Z* (co-first author), Teresky AK., Levine AJ. P53 regulates maternal reproduction through LIF. Nature; 450 (7170): 721-724.
  15. Feng Z, Hu W, Yu H, Tang MS. Acrolein is a major cigarette-related lung cancer agent: preferential binding at p53 mutational hotspots and inhibition of DNA repair. Proc Natl Acad Sci U S A, 103:15404-15409. (2006).
  16. Feng Z, Zhang H, Levine AJ, Jin S. The coordinate regulation of the p53 and mTOR pathways in cells. Proc Natl Acad Sci U S A, 102:8204-8209. (2005).
  17. Feng Z, Hu W, Tang MS. (2004) Trans-4-hydroxy-2-nonenal inhibits nucleotide excision repair in human cells: a possible mechanism for lipid peroxidation-induced carcinogenesis. Proc Natl Acad Sci U S A, 101:8598-8602 PMID: 15187227; PMCID: PMC423240.
  18. Feng Z, Hu W, Chen JX, Pao A, Li H, Rom W, Hung MC, Tang MS. (2002) Preferential DNA damage and poor repair determine ras gene mutational hotspot in human cancer (see editorial). J Natl Cancer Inst., 94:1527-1536. PMID: 12381705.
Complete List of Published Work in MyNCBI

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